Migofen (200/12.8mg) 100 Tablets

Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), primarily works by inhibiting cyclooxygenase (COX) enzymes, particularly COX-1 and COX-2. This inhibition reduces the formation of prostaglandins, which are key mediators of inflammation, pain, and fever. By decreasing prostaglandin production, ibuprofen helps alleviate pain, reduce inflammation, and lower fever. It acts peripherally to reduce the sensitivity of pain receptors and inhibit the release of inflammatory mediators. Codeine, on the other hand, is an opioid analgesic that acts on the central nervous system. It binds to opioid receptors, particularly the mu-opioid receptors in the brain and spinal cord, leading to a decrease in the perception of pain signals. Codeine's mechanism involves inhibiting the transmission of pain signals and increasing the perception of pain tolerance, thereby providing analgesic effects.

Ibuprofen, Codeine Phosphate Hemihydrate

NSAID (Non-steroidal anti-inflammatory drug) and Opioid.

Tablet

The following are the uses of Ibuprofen, Codeine Phosphate Hemihydrate Tablet:

• Used for relieving mild to moderate pain, such as headaches, toothaches, backaches, and menstrual cramps.
• Used for reducing inflammation and managing symptoms of conditions like arthritis.
• Used for lowering fever and treating symptoms of the common cold or flu.
• Used for providing pain relief after minor surgeries or medical procedures.
• Used for alleviating discomfort associated with upper respiratory tract infections.
• Used for managing pain and inflammation in conditions like sprains and strains.
• Used for treating pain and discomfort caused by migraines.
• Used for offering short-term relief from acute pain.

In the case of an overdose of Ibuprofen, symptoms may include nausea, vomiting, abdominal pain, and in severe cases, gastrointestinal bleeding. With Codeine Phosphate Hemihydrate Tablet overdose, one can experience respiratory depression, drowsiness, and even loss of consciousness. Immediate medical intervention is required, and treatment may involve gastric lavage, administration of activated charcoal, and supportive care to manage symptoms until the drugs are eliminated from the body.

In the case of a missed dose of Ibuprofen, it is generally recommended to take the missed dose as soon as you remember, but if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. For Codeine Phosphate Hemihydrate Tablets, if a dose is missed, take it as soon as possible, but if it is close to the time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose to make up for a missed one.

To take Ibuprofen, Codeine Phosphate Hemihydrate Tablets, swallow the tablets whole with a full glass of water, ensuring you follow the prescribed dosage as directed by your healthcare professional, typically taken every 4 to 6 hours, or as instructed by your doctor, without crushing, chewing, or breaking the tablets.

Following are the conditions/situations when Ibuprofen, Codeine Phosphate Hemihydrate Tablet should not be used:

• Should not be used in individuals with a known allergy or hypersensitivity to ibuprofen, codeine, or any other ingredients in the medication.
• Contraindicated in patients with a history of gastrointestinal bleeding or perforation related to previous NSAID (non-steroidal anti-inflammatory drugs) therapy.
• Not recommended for individuals with active peptic ulcer disease or gastrointestinal bleeding.
• Avoid using in patients with severe liver impairment or severe kidney disease.
• Should not be used in patients who have recently undergone certain surgeries, such as coronary artery bypass graft (CABG) surgery.
• Contraindicated in patients with severe respiratory depression or asthma attacks triggered by codeine or other opioids.
• Not suitable for individuals with a history of seizures or conditions that increase the risk of seizures.
• Avoid using in patients with head injuries or increased intracranial pressure.
• Should not be used in patients with severe diarrhea caused by antibiotics or other medications.

The side effects of Ibuprofen and Codeine Phosphate Hemihydrate Tablet may include:

• Stomach pain or upset
• Nausea and vomiting
• Dizziness or lightheadedness
• Constipation
• Dry mouth
• Sweating
• Itching or skin rash
• Difficulty breathing or swallowing

Following are the precautions and warnings for Ibuprofen, Codeine Phosphate Hemihydrate Tablet:

• This medication should not be used in individuals with a known allergy to ibuprofen, codeine, or any other ingredients in the tablet.
• Patients with a history of gastrointestinal bleeding, peptic ulcers, or asthma should use this medication with caution, as it may worsen these conditions.
• It is important to avoid alcohol consumption while taking this medication, as it may increase the risk of gastrointestinal bleeding and liver damage.
• Patients with kidney or liver disease should exercise caution and consult a healthcare professional before use, as dosage adjustments may be necessary.
• The medication may cause dizziness or drowsiness, so patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Ibuprofen may increase blood pressure, so individuals with hypertension should be monitored regularly.
• Codeine can be habit-forming, and prolonged use may lead to physical dependence. It should be used with caution and only as directed by a healthcare professional.
• Elderly patients may be more sensitive to the side effects of this medication, and regular monitoring is advised.

Following are the drug interactions for Ibuprofen, Codeine Phosphate Hemihydrate Tablet:

• Ibuprofen may increase the risk of bleeding when taken with anticoagulants (e.g., warfarin) and antiplatelet drugs (e.g., aspirin), and close monitoring is required.
• It can interact with ACE inhibitors and angiotensin receptor blockers (ARBs), reducing their effectiveness in controlling blood pressure.
• Ibuprofen may decrease the efficacy of diuretics, including loop and thiazide diuretics, potentially leading to decreased diuresis and increased blood pressure.
• The risk of nephrotoxicity is increased when combined with other nephrotoxic agents, such as cyclosporine or aminoglycoside antibiotics.
• Codeine may interact with other central nervous system depressants like benzodiazepines, alcohol, or other opioids, enhancing sedation and respiratory depression.
• It is metabolized by CYP2D6, and inhibitors of this enzyme (e.g., fluoxetine, paroxetine) can reduce the effectiveness of codeine, while inducers (e.g., rifampicin) may increase its metabolism.
• Concomitant use with serotonergic drugs (e.g., SSRIs, SNRIs) may increase the risk of serotonin syndrome, a potentially serious condition.

Following are the food interactions for Ibuprofen, Codeine Phosphate Hemihydrate Tablet:

• Alcohol consumption should be avoided or limited while taking this medication as it may increase the risk of stomach bleeding and liver damage.
• Grapefruit and grapefruit juice should be consumed with caution as they can interfere with the metabolism of Codeine, potentially leading to increased side effects and toxicity.
• Caffeine-containing beverages like coffee, tea, and energy drinks may enhance the stimulating effects of Codeine, causing increased alertness and potential sleep disturbances.
• Foods high in sodium (salt) may interact with Ibuprofen, increasing the risk of high blood pressure and fluid retention. It's advisable to limit salty foods.
• Avoid high-fat meals as they can delay the absorption of Codeine, potentially affecting its pain-relieving effects.
• Ibuprofen may reduce the blood's ability to clot, so foods rich in vitamin K (e.g., leafy greens) should be consumed consistently to maintain normal blood clotting.
• Ensure adequate fluid intake to reduce the risk of gastrointestinal side effects associated with Ibuprofen.

Ibuprofen, Codeine Phosphate Hemihydrate Tablets should be stored in a secure and dry location, preferably at room temperature, away from direct exposure to sunlight, moisture, and heat sources like ovens or radiators. It is crucial to keep the tablets in their original packaging, tightly sealed, to maintain their integrity and prevent contamination. Pay attention to the expiration date on the package, and ensure proper disposal of any unused or expired tablets. Do not dispose of them in toilets or drains; instead, consult your pharmacist or local waste management guidelines for safe disposal methods. Keep the medication away from children to prevent accidental consumption, as it can be harmful if ingested inappropriately. Proper storage and disposal practices are essential for maintaining safety and efficacy.

Following are the quick tips for Ibuprofen and Codeine Phosphate Hemihydrate Tablet:

• Consult a doctor or pharmacist before use, especially if you have existing medical conditions or are taking other medications.
• Take the tablet with or after food to minimize stomach irritation.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Avoid alcohol consumption while taking these medications.
• Do not drive or operate heavy machinery until you know how these medications affect you.
• If you experience dizziness, lie down until it passes.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.