Minidiab AF (2.5/500mg) 10 Tablets

Metformin 250mg and Glipizide 2.5 mg are commonly combined in a tablet to manage type 2 diabetes. Metformin primarily works by reducing glucose production in the liver through the inhibition of gluconeogenesis and glycogenolysis. It also enhances insulin sensitivity in peripheral tissues, allowing for better glucose uptake. On the other hand, Glipizide belongs to the sulfonylurea class and acts by stimulating the release of insulin from pancreatic beta cells. It achieves this by blocking ATP-sensitive potassium channels in the pancreatic beta cells, leading to their depolarization and subsequent insulin secretion. This combined mechanism helps lower blood glucose levels in individuals with type 2 diabetes.

Oral hypoglycemic agents.

Tablet

The following are the uses of Metformin 250mg, Glipizide 2.5 mg Tablet:

• Used for controlling blood sugar levels in type 2 diabetes.
• Used to improve insulin sensitivity and reduce insulin resistance.
• Used to support weight loss and manage obesity, especially in diabetic patients.
• Used to lower the risk of cardiovascular complications associated with diabetes.
• Used for preventing long-term diabetes complications like kidney damage and nerve damage.
• Used to enhance glycemic control when combined with a healthy diet and exercise.
• Used as an adjunct therapy to other diabetes medications for better blood sugar management.

In the case of an overdose of Metformin 250mg and Glipizide 2.5 mg, immediate symptoms may include nausea, vomiting, stomach pain, and diarrhea. More severe effects can lead to lactic acidosis, characterized by deep, rapid breathing, tiredness, and unusual muscle pain. It is important to recognize that an overdose can have serious consequences, and seeking medical assistance promptly is crucial to ensure appropriate treatment and management of these symptoms.

In the case of a missed dose of Metformin 250mg, it is generally recommended to take the missed dose as soon as you remember, but if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. For Glipizide 2.5 mg, if you miss a dose, take it as soon as you remember, however, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

To take the Metformin 250mg and Glipizide 2.5 mg tablet, swallow the tablet whole with a full glass of water, preferably during a meal or as directed by your healthcare provider, once or twice daily, following the dosage instructions provided by your doctor.

Here are the conditions or situations when Metformin 250mg and Glipizide 2.5 mg Tablet should not be taken:

• Avoid if allergic to any component of the medication, including Metformin or Glipizide.
• Not suitable for patients with kidney or liver disease or impairment.
• Contraindicated in individuals with a history of diabetic ketoacidosis.
• Should not be used if you have a severe infection, trauma, or are experiencing surgery, as it may increase the risk of lactic acidosis.
• Not recommended for individuals with respiratory diseases, such as severe asthma or COPD.
• Avoid if you have a history of heart disease or heart failure.
• Should not be used if you are experiencing dehydration or have a history of excessive alcohol consumption.
• Contraindicated during pregnancy and breastfeeding.
• Not suitable for individuals with a history of gastrointestinal diseases or blockage.

The side effects of Metformin 250mg and Glipizide 2.5 mg Tablet may include:

• Nausea and vomiting
• Diarrhea
• Stomach pain
• Headache
• Dizziness
• Skin rash or itching
• Metallic taste in the mouth
• Low blood sugar (hypoglycemia)

Following are the precautions and warnings for Metformin 250mg, Glipizide 2.5 mg Tablet:

• Individuals with a known allergy to Metformin or Glipizide should not take this medication.
• Patients with a history of liver or kidney problems should use this medication with caution as dose adjustments may be necessary.
• Alcohol consumption should be avoided as it can increase the risk of lactic acidosis, a serious side effect.
• Patients should be monitored for signs of hypoglycemia, especially during the initial treatment period.
• This medication may cause a decrease in vitamin B12 levels, so regular monitoring is advised.
• Elderly patients may be more susceptible to the side effects of this medication, particularly lactic acidosis.
• Patients should inform their healthcare provider of any other medications they are taking to avoid potential drug interactions.
• Those with a history of heart or respiratory problems should exercise caution and consult their doctor before use.

Following are the drug interactions for Metformin 250mg and Glipizide 2.5 mg Tablet:

• Cimetidine and Ranitidine can increase the blood levels of Glipizide, potentially leading to hypoglycemia.
• Rifampin may decrease the effectiveness of Glipizide by inducing its metabolism.
• Metformin's renal excretion can be impaired by Cimetidine, increasing the risk of lactic acidosis.
• Alcohol can potentiate the hypoglycemic effect of Glipizide, and may also increase the risk of lactic acidosis with Metformin.
• Certain diuretics (e.g., Furosemide) may increase the risk of lactic acidosis when used with Metformin.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) can elevate blood glucose levels and reduce the effectiveness of Glipizide.
• Glipizide may increase the effects of sulfonamides, potentially leading to hypoglycemia.
• The hypoglycemic effect of Glipizide may be reduced by corticosteroids.

Following are the food interactions for Metformin 250mg and Glipizide 2.5 mg Tablet:

• Alcohol consumption should be limited as it can increase the risk of hypoglycemia, especially with Glipizide.
• Avoid excessive alcohol intake as it may interfere with blood glucose control and liver function.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Glipizide, leading to increased drug levels and potential side effects.
• High-fiber foods like whole grains, legumes, and vegetables can help slow the absorption of Glipizide, reducing the risk of blood sugar spikes.
• Fatty foods may delay the absorption of Metformin, potentially affecting its effectiveness.
• Avoid excessive intake of sugary foods and beverages as they can impact blood glucose levels.
• Consuming a balanced diet with consistent carbohydrate intake can help manage blood sugar levels effectively.
• No significant food interactions are known for Metformin, but maintaining a healthy diet is essential for overall diabetes management.

Metformin 250mg and Glipizide 2.5 mg tablets should be stored in a cool, dry place, preferably at room temperature between 68°F and 77°F (20°C and 25°C). Keep the tablets in their original container, tightly closed, to maintain their integrity and protect them from moisture and light. It is crucial to store the medication away from heat, direct sunlight, and freezing temperatures, as these conditions can degrade the tablets. Always check the expiration date and dispose of any expired or unused tablets promptly. Proper disposal methods include returning them to a pharmacy or healthcare facility for safe disposal, ensuring they do not contaminate the environment. Keep the medication out of children's reach to prevent accidental ingestion.

Following are the quick tips for Metformin 250mg and Glipizide 2.5 mg Tablet:

• Always take the medication as directed by your doctor; do not adjust the dosage without medical advice.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• Maintain a consistent medication schedule, preferably with meals, to enhance effectiveness.
• Inform your doctor if you experience persistent nausea, vomiting, or stomach pain.
• Regularly monitor your blood sugar levels as advised by your healthcare provider.
• Store the medication at room temperature, away from moisture and heat.
• Keep all medications out of sight and reach of children.