Misar AM (40/10mg) 20 Tablets

Amlodipine 10mg and Telmisartan 40mg work synergistically in this tablet to lower blood pressure through distinct mechanisms of action. Amlodipine, a calcium channel blocker, inhibits the movement of calcium ions into vascular smooth muscle cells, leading to vasodilation and reduced peripheral vascular resistance. This relaxation of blood vessels decreases blood pressure by easing the heart's workload. On the other hand, Telmisartan is an angiotensin II receptor blocker (ARB). It blocks the angiotensin II hormone from binding to its receptors, which normally causes vasoconstriction and the release of aldosterone, a hormone that increases blood pressure. By blocking these receptors, Telmisartan promotes vasodilation, reduces blood pressure, and decreases the release of aldosterone, thus preventing sodium and water retention.

Amlodipine 10mg, Telmisartan 40mg

Calcium channel blocker, Angiotensin II receptor blocker.

Tablet

The following are the uses of Amlodipine 10mg, Telmisartan 40mg Tablet:

• Used for managing high blood pressure (hypertension)
• Used for preventing and treating chest pain (angina)
• Used to relax and widen blood vessels, improving blood flow
• Used to reduce the risk of heart attack and stroke
• Used to manage hypertension-related kidney issues
• Used to lower blood pressure, easing the heart's workload
• Used for patients with high blood pressure and heart disease
• Used to treat hypertension and related complications

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Take 1 tablet per day.
• Dosage should be adjusted based on the severity of the disease and response to treatment.

In the case of an overdose of Amlodipine 10mg and Telmisartan 40mg tablets, it is important to recognize the potential risks. Symptoms may include severe hypotension, bradycardia, and even heart failure. Prompt medical intervention is necessary, as this combination can lead to life-threatening complications. Emergency treatment may involve gastric lavage, supportive care, and close monitoring of vital signs to ensure the patient's safety and well-being.

In the case of a missed dose of Amlodipine 10mg, take the missed dose as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. For Telmisartan 40mg Tablet, if you miss a dose, take it as soon as you remember. However, if it's close to the time for your next dose, skip the missed dose and continue with your regular dosing regimen. Do not double the dose to make up for a missed one, and ensure you follow the prescribed schedule as closely as possible.

To take Amlodipine 10mg and Telmisartan 40mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, as directed by your healthcare provider.

Following are the conditions or situations when Amlodipine 10mg, Telmisartan 40mg Tablet should not be taken:

• Avoid if you have a known allergy to Amlodipine, Telmisartan, or other related medications.
• Do not use if you are pregnant or planning to become pregnant.
• Not suitable for individuals with severe liver disease or impaired liver function.
• Should not be taken if you have a history of angioedema (swelling of the face, lips, tongue, or throat) with previous use of similar medications.
• Contraindicated in patients with severe aortic stenosis (narrowing of the aortic valve in the heart).
• Avoid if you have severe hypotension (very low blood pressure).
• Not recommended for individuals with severe renal impairment or patients on dialysis.
• Do not use if you have a condition called hepatic biliary cirrhosis.
• Should not be taken if you have a history of heart failure or cardiogenic shock.

The side effects of Amlodipine 10mg, Telmisartan 40mg Tablet may include:

• Dizziness or lightheadedness
• Swelling of the ankles or feet (peripheral edema)
• Headache
• Fatigue or drowsiness
• Nausea and vomiting
• Stomach pain or discomfort
• Skin rash or itching
• Muscle cramps

Following are the precautions and warnings for Amlodipine 10mg, Telmisartan 40mg Tablet:

• Individuals with a known allergy to Amlodipine, Telmisartan, or related medications should not take this tablet.
• Patients with a history of liver or kidney problems should exercise caution, as these conditions may affect the metabolism and excretion of the drug.
• This medication may cause dizziness or lightheadedness; patients should avoid activities requiring alertness until they know how the medication affects them.
• Elderly patients may be more sensitive to the effects of this medication, and dosage adjustments might be necessary.
• Pregnant and breastfeeding women should consult their doctor, as this medication may have potential risks for the fetus or infant.
• It is important to maintain a consistent blood pressure monitoring schedule while on this medication.
• Inform your doctor about all other medications you are taking to prevent potential drug interactions.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.

Following are the drug interactions for Amlodipine 10mg, Telmisartan 40mg Tablet:

• Amlodipine may enhance the blood pressure-lowering effects of other antihypertensive medications, such as beta-blockers or ACE inhibitors, leading to excessive hypotension.
• The combination with CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) can increase amlodipine levels, potentially causing increased side effects.
• Telmisartan may have additive effects with other medications that affect the renin-angiotensin system (e.g., ACE inhibitors, aliskiren), increasing the risk of hypotension and renal impairment.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the antihypertensive effects of telmisartan and amlodipine.
• Telmisartan may increase serum lithium levels, requiring close monitoring of lithium concentrations.
• Grapefruit juice may increase amlodipine levels, leading to enhanced blood pressure-lowering effects and potential side effects.
• Rifampicin, a CYP3A4 inducer, may decrease amlodipine levels, potentially reducing its therapeutic efficacy.
• Concomitant use with diuretics may increase the risk of hypotension, especially in volume-depleted patients.

Following are the food interactions for Amlodipine 10mg and Telmisartan 40mg Tablet:

• Grapefruit and grapefruit juice should be consumed with caution as they can increase the blood levels of Amlodipine, potentially leading to an increased risk of side effects such as low blood pressure and dizziness.
• High-sodium foods should be avoided or limited as Telmisartan is a blood pressure-lowering medication, and excessive sodium intake can counteract its effectiveness.
• Limit the consumption of alcohol as it may increase the blood pressure-lowering effect of Telmisartan and Amlodipine, leading to dizziness or lightheadedness.
• Potassium-rich foods like bananas, oranges, and spinach should be consumed in moderation as Telmisartan can increase potassium levels in the body, and excessive intake may lead to hyperkalemia.
• Avoid or limit high-potassium foods when taking Amlodipine, as it can also affect potassium levels, and excessive intake might cause irregular heart rhythms.
• Avoid or reduce the intake of licorice as it may decrease the effectiveness of Telmisartan and potentially increase blood pressure.
• Caffeine intake should be monitored as it can interfere with blood pressure regulation, and excessive consumption might counteract the effects of Amlodipine and Telmisartan.
• Always stay hydrated and maintain a balanced diet, as proper hydration and nutrition are essential for the optimal functioning of these medications.

Amlodipine 10mg and Telmisartan 40mg tablets should be stored in a cool, dry place, preferably at room temperature, ensuring protection from light and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. It is crucial to keep the medication away from heat sources like radiators or ovens, as extreme temperatures can impact its effectiveness. Regularly check the expiration date, and if the medication is no longer needed or has expired, proper disposal is essential. Avoid flushing or pouring it down the drain; consult a pharmacist for guidance on safe disposal methods. Always keep medicines out of children's reach to prevent accidental consumption.

Following are the quick tips for Amlodipine 10mg and Telmisartan 40mg Tablet:

• Consult your doctor for the correct dosage and prescription.
• Take the tablet as directed, usually once daily.
• Consume the tablet at the same time each day for best results.
• Swallow the tablet whole with a glass of water, do not crush or chew.
• Take the medication regularly for optimal blood pressure control.
• Do not stop taking the tablet without consulting your doctor.
• Store in a cool, dry place, away from direct sunlight.
• Inform your doctor about all medications you are currently taking.

Both Amlodipine and Olmesartan Medoxomil are medications prescribed to help treat high blood pressure, a condition also known as hypertension. These medications are effective in reducing blood pressure, but to ensure they are safely doing so, certain relevant lab tests may be required. Firstly, it is vital to regularly monitor your blood pressure to ensure the medications are working as intended and to adjust any dosage if needed. Furthermore, as both medicines can cause the levels of potassium in the blood to increase, blood tests to monitor potassium levels may be recommended. Maintaining a normal level of potassium is crucial to prevent any further complications. Diabetic patients may be required to have fasting blood sugar levels tested on a monthly basis, and for those who have undergone the glycosylated hemoglobin test, adjustments can be made to diabetes control every three months. However, it is worth noting that the need for these specific tests will depend on individual circumstances and the advice of your doctor. Overall, it is important to communicate with your doctor and adhere to their guidance on lab tests and monitoring to ensure your treatment is safe and effective in the long term, and any concerns in relation to blood tests or side effects can be adequately addressed by your doctor.