MISAR H 40/12.5 MG TAB 20S

Hydrochlorothiazide in Hydrochlorothiazide, Telmisartan Tablet acts as a diuretic by inhibiting the reabsorption of sodium and chloride ions in the distal convoluted tubule of the kidney. This action promotes the excretion of water and electrolytes, leading to increased urine production and a reduction in blood volume. Telmisartan, on the other hand, is an angiotensin II receptor blocker (ARB). It selectively blocks the binding of angiotensin II to its receptors, primarily in the vascular smooth muscle. Angiotensin II is a potent vasoconstrictor, so by blocking its effects, telmisartan causes vasodilation, which reduces peripheral resistance and lowers blood pressure. This mechanism helps to decrease blood pressure and improve blood flow, contributing to the overall antihypertensive effect of the combination therapy.

Hydrochlorothiazide, Telmisartan

Angiotensin II Receptor Blocker, Thiazide Diuretic.

Tablet

The following are the uses of Hydrochlorothiazide, Telmisartan Tablet:

• Used for treating high blood pressure (hypertension)
• Used to lower blood pressure and reduce the risk of cardiovascular events
• Used to manage hypertension when one medication alone is not sufficient
• Used to promote blood vessel relaxation and increase water elimination
• Used to control blood pressure and improve cardiovascular health
• Used to treat hypertension in patients who may have difficulty swallowing multiple tablets
• Used as a long-term treatment option for maintaining healthy blood pressure levels
• Used to reduce the workload on the heart and improve overall cardiovascular function

In the case of an overdose of Hydrochlorothiazide and Telmisartan Tablets, symptoms may include excessive urination, hypotension, and electrolyte imbalances. Seek medical advice promptly if you suspect an overdose, as it may lead to severe dehydration and potential kidney complications. Timely intervention can help manage symptoms and prevent further health deterioration. Prompt recognition and appropriate medical care are essential to ensure the best possible outcome.

In the case of a missed dose of Hydrochlorothiazide, it is generally advised to take the missed dose as soon as you remember, unless it is almost time for your next scheduled dose. If it is close to the time of your next dose, skip the missed dose and continue with your regular dosing schedule. For Telmisartan, if you miss a dose, take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose and continue with your regular dosing regimen. It's important to maintain a consistent medication schedule, but don't double the dose to make up for a missed one.

To take Hydrochlorothiazide, Telmisartan Tablet, swallow the tablet whole with a glass of water, preferably in the morning as directed by your healthcare provider. It is recommended to take the tablet at the same time each day to maintain consistent blood levels and maximize its effectiveness.

Here are the conditions and situations when Hydrochlorothiazide and Telmisartan tablets should not be used:

• Must not be used in patients with a known allergy to either Hydrochlorothiazide or Telmisartan, or any other sulfonamide-derived drugs.
• Contraindicated in patients with severe renal impairment or anuria (absence of urine production).
• Not suitable for individuals with significant liver dysfunction or progressive liver disease.
• Should be avoided in patients with severe hypotension (very low blood pressure) or who are experiencing episodes of hypotension.
• Not recommended for patients with hyperkalemia (high potassium levels in the blood).
• Should not be used during pregnancy, especially during the second and third trimesters, due to potential harm to the fetus.
• Contraindicated in patients with a history of angioedema (a serious allergic reaction) associated with previous use of ACE inhibitors or ARBs.
• Not suitable for individuals with bilateral renal artery stenosis (narrowing of the arteries supplying the kidneys).
• Should be used with caution and under medical supervision in patients with unilateral renal artery stenosis, and may be contraindicated if the condition is severe.
• Should not be used in patients with conditions that lead to severe dehydration or significant fluid loss, as it may cause electrolyte imbalances.

The side effects of Hydrochlorothiazide, Telmisartan Tablet may include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Nausea and vomiting
• Diarrhea or constipation
• Dry mouth or increased thirst
• Skin rash or itching
• Muscle cramps or joint pain
• Low blood pressure (hypotension)

Following are the precautions and warnings for Hydrochlorothiazide, Telmisartan Tablet:

• This medication is contraindicated in patients who are hypersensitive to any component of the tablet or other sulfonamide-derived drugs.
• Regular monitoring of kidney function and electrolytes is essential, especially in patients with pre-existing kidney disease.
• Caution is advised for patients with impaired liver function as Telmisartan is primarily metabolized in the liver.
• It may cause dizziness or lightheadedness, especially when standing up or sitting down suddenly, so patients should rise slowly to prevent falls.
• Patients with a history of angioedema should be closely monitored as Telmisartan may cause swelling of the face, lips, throat, or tongue.
• Avoid using potassium supplements or salt substitutes containing potassium without medical advice, as Hydrochlorothiazide can affect potassium levels.
• This medication may cause dehydration, so patients should drink plenty of fluids, especially in hot weather or during vigorous exercise.

Following are the drug interactions for Hydrochlorothiazide, Telmisartan Tablet:

• Hydrochlorothiazide may reduce the elimination of lithium, leading to increased lithium levels and potential toxicity. Close monitoring of lithium levels is recommended.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen may decrease the blood pressure-lowering effect of Telmisartan.
• Telmisartan may increase the levels of potassium in the blood, and when used with potassium-sparing diuretics or potassium supplements, it can lead to hyperkalemia.
• Angiotensin-converting enzyme (ACE) inhibitors and Hydrochlorothiazide can have additive effects on potassium levels, and monitoring is necessary to prevent hyperkalemia.
• The antihypertensive effects of Telmisartan may be reduced by nonsteroidal anti-inflammatory drugs (NSAIDs).
• Hydrochlorothiazide can enhance the nephrotoxicity of certain drugs like cisplatin and methotrexate, requiring careful monitoring of kidney function.
• The diuretic effect of Hydrochlorothiazide may reduce the elimination of other drugs metabolized by the liver, potentially increasing their blood levels.
• Caution is advised when combining Telmisartan with other medications that affect the renin-angiotensin system, as it may lead to increased risks of hypotension and renal impairment.

Following are the food interactions for Hydrochlorothiazide, Telmisartan Tablet:

• Avoid excessive salt intake, as the medication's effectiveness may be reduced, leading to increased blood pressure.
• Potassium-rich foods like bananas, oranges, and spinach are beneficial as Hydrochlorothiazide can cause potassium loss.
• Limit alcohol consumption as it may increase the risk of dizziness and lightheadedness, especially when standing from a sitting or lying position.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Telmisartan, potentially altering its effectiveness.
• Maintain a balanced diet, as this medication may affect blood sugar levels, particularly in diabetic patients.
• Avoid potassium supplements unless prescribed by a doctor, as they can lead to high potassium levels in the blood.
• Stay hydrated, but be cautious with excessive fluid intake, especially in cases of liver or kidney disease.

Hydrochlorothiazide, Telmisartan tablets should be stored properly to maintain their effectiveness and ensure safety. Keep the tablets in their original container, tightly sealed, and store them in a cool, dry place away from direct sunlight and moisture. Avoid exposing the medication to high temperatures or humidity, as this can degrade its quality. It is crucial not to store the tablets in the bathroom medicine cabinet due to the potential for heat and moisture exposure. Always check the expiration date, and if the medication is past its expiry, do not use it and dispose of it carefully. Proper disposal methods are essential; do not flush the tablets or throw them into the trash. Consult your pharmacist or local waste management guidelines for the correct way to dispose of unused or expired medication, ensuring it is done responsibly and with minimal environmental impact. Keep all medicines out of children's reach to prevent accidental ingestion.

Following are the quick tips for Hydrochlorothiazide, Telmisartan Tablet:

• Consult your doctor before starting this medication for personalized advice.
• Follow the prescribed dosage and duration for effective blood pressure control.
• Take the tablet as directed, typically once daily, and at the same time for consistency.
• Swallow the tablet whole with a glass of water, avoiding crushing or chewing.
• Avoid taking antacids or potassium supplements within 2 hours of this medication.
• Regularly monitor your blood pressure and kidney function as advised by your doctor.
• Store the medication in a cool, dry place, away from direct sunlight.