Misar H (80/12.5mg) 20 Tablets

Telmisartan and Hydrochlorothiazide are combined in this tablet to treat hypertension. Telmisartan blocks the angiotensin II receptor type 1 (AT1) in the body, preventing the binding of angiotensin II, a potent vasoconstrictor, and aldosterone-releasing hormone. This inhibition leads to decreased vasoconstriction and aldosterone secretion, resulting in reduced blood pressure and diuresis. Hydrochlorothiazide, a thiazide diuretic, inhibits the reabsorption of sodium and chloride ions in the distal convoluted tubule of the kidney, promoting the excretion of water and sodium, which helps lower blood volume and blood pressure. Together, these mechanisms provide a synergistic effect in controlling hypertension.

Angiotensin II Receptor Blocker, Thiazide Diuretic

Tablet

The following are the uses of Telmisartan 80mg, Hydrochlorothiazide 12.5mg Tablet:

• Used for treating high blood pressure (hypertension)
• Used to lower blood pressure and reduce the risk of cardiovascular events
• Used in cases where blood pressure is not controlled by a single medication
• Used to manage fluid retention and edema
• Used in combination to enhance the effectiveness of blood pressure control
• Used for long-term management of hypertension
• Used to improve blood flow and reduce strain on the heart

In the case of an overdose of Telmisartan 80mg and Hydrochlorothiazide 12.5mg tablets, the severity of symptoms can vary. Common signs may include dizziness, hypotension, and increased urination. In more serious cases, individuals may experience significant drops in blood pressure, leading to fainting or shock. It is crucial to seek medical assistance promptly, as healthcare professionals can provide the necessary support and treatment to manage the overdose effectively.

In the case of a missed dose of Telmisartan 80mg, Hydrochlorothiazide 12.5mg Tablet, it is generally recommended to take the missed dose as soon as you remember, provided it is not too close to the time of your next scheduled dose. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. It is important to maintain a consistent medication routine, so try to take your medication at the same time each day to ensure optimal effectiveness.

To take the Telmisartan 80mg, Hydrochlorothiazide 12.5mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, as directed by your healthcare provider.

Following are the conditions when Telmisartan 80mg and Hydrochlorothiazide 12.5mg Tablet should not be used:

• Should not be used in patients with a known allergy to Telmisartan, Hydrochlorothiazide, or any other angiotensin II receptor blockers (ARBs).
• Contraindicated in individuals with a history of severe, persistent diarrhea or vomiting, as it may lead to dehydration.
• Not recommended for patients with severe kidney disease or those on dialysis.
• Should not be used in individuals with anuria (absence of urine production).
• Contraindicated during pregnancy, especially in the second and third trimesters.
• Not suitable for individuals with low blood pressure (hypotension).
• Should be avoided in patients with severe liver disease or biliary obstruction.
• Not recommended for individuals with a history of angioedema (swelling of the face, lips, or tongue) associated with previous use of similar medications.
• Contraindicated in patients with hyperkalemia (high potassium levels in the blood).
• Should not be used in patients with gout, as it may increase uric acid levels.

The side effects of Telmisartan 80mg, Hydrochlorothiazide 12.5mg Tablet may include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Nausea and vomiting
• Diarrhea or constipation
• Dry mouth
• Skin rash or itching
• Muscle cramps
• Increased sensitivity to sunlight

Following are the precautions and warnings for Telmisartan 80mg, Hydrochlorothiazide 12.5mg Tablet:

• Not recommended for individuals with known allergies to Telmisartan, Hydrochlorothiazide, or related medications.
• Patients with kidney disease or a history of angioedema should exercise caution and consult a doctor before use.
• Regular monitoring of kidney function and blood electrolytes is necessary during treatment.
• May cause dizziness, especially when standing up; patients should rise slowly to prevent falls.
• Not suitable for pregnant or breastfeeding women unless advised by a healthcare professional.
• Elderly patients may require lower doses as they are more prone to side effects.
• Inform your doctor of all medications you are taking to avoid potential drug interactions.
• Discontinue use and seek medical attention if you experience symptoms like severe dizziness, fainting, or allergic reactions.

Following are the drug interactions for Telmisartan 80mg and Hydrochlorothiazide 12.5mg Tablet:

• The combination of Telmisartan and Hydrochlorothiazide may increase the risk of hypotension, especially in patients who are volume-depleted or have low sodium levels.
• Hydrochlorothiazide may reduce the antihypertensive effect of Telmisartan when taken with certain nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen and naproxen.
• Concurrent use of Telmisartan with other angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) can increase the risk of hyperkalemia and kidney dysfunction.
• Taking Telmisartan with potassium supplements or potassium-sparing diuretics (e.g., spironolactone) may increase the risk of hyperkalemia, leading to potentially dangerous heart rhythms.
• Hydrochlorothiazide may increase the risk of lithium toxicity when taken together, as it reduces renal clearance of lithium.
• The combination of Telmisartan and Hydrochlorothiazide may enhance the risk of dehydration, electrolyte imbalances (e.g., hypokalemia, hyponatremia), and hypotension, particularly in patients with kidney disease.
• Hydrochlorothiazide may increase blood glucose levels and decrease insulin sensitivity, which could worsen control of diabetes, especially when combined with other antidiabetic medications.
• The use of Telmisartan with other antihypertensive agents (e.g., calcium channel blockers, beta-blockers) may result in an additive lowering of blood pressure.
• Caution is advised when taking Telmisartan and Hydrochlorothiazide in combination with corticosteroids, as these drugs may enhance the risk of electrolyte imbalances.
• Patients on digoxin therapy should be monitored for digoxin toxicity, as Hydrochlorothiazide may increase the plasma concentration of digoxin.
• The combination of these medications with other diuretics may increase the risk of dehydration, hypotension, and renal dysfunction, especially in elderly patients.

Following are the food interactions for Telmisartan 80mg, Hydrochlorothiazide 12.5mg Tablet:

• Avoid excessive salt intake, as this medication can cause increased sensitivity to salt, leading to higher blood pressure and fluid retention.
• Limit potassium-rich foods like bananas, oranges, and spinach as Hydrochlorothiazide can increase potassium excretion, potentially causing low potassium levels.
• Alcohol may increase the risk of dizziness and lightheadedness, especially when standing up, as it can affect blood pressure.
• Grapefruit and grapefruit juice should be consumed with caution, as they may affect the metabolism of Telmisartan, altering its effectiveness.
• Maintain a balanced diet; consult your doctor or dietician for specific dietary advice while taking this medication.
• Avoid licorice or licorice-containing products as they can interfere with the medication's effects on blood pressure regulation.
• Stay hydrated, but be mindful of excessive fluid intake, as it may affect electrolyte balance.

Telmisartan 80mg, Hydrochlorothiazide 12.5mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. Keep the tablets in their original packaging, tightly sealed, to maintain their integrity and prevent contamination. It is crucial not to store them in the bathroom or near heat-emitting appliances, as temperature fluctuations can impact their effectiveness. Dispose of any unused or expired tablets responsibly; do not flush them or pour them down the drain. Consult a pharmacist or healthcare professional for guidance on proper disposal methods, and keep the medication away from children to prevent accidental consumption.

Following are the quick tips for Telmisartan 80mg, Hydrochlorothiazide 12.5mg Tablet:

• Adhere to the dosage prescribed by your doctor for effective blood pressure control.
• Take the tablet at the same time each day to establish a consistent routine.
• Ensure you swallow the tablet whole with a sufficient amount of water.
• It can be taken with or without food, but consistency is key.
• Avoid crushing or chewing the tablet for optimal absorption.
• If you miss a dose, take it as soon as you remember, unless it's close to your next dose.
• Regularly monitor your blood pressure and consult your doctor for adjustments if needed.