Misartan-H (40/12.5mg) 10 Tablets

It contains; Telmisartan and Hydrochlorothiazide as its active components. Telmisartan: angiotensin II Receptor Blocker is an antihypertensive agent, It works by blocking the vasoconstrictor and aldosterone secretory effects of angiotensin II, to treat the tightening of blood vessels. As a result, blood vessels are relaxed and this phenomenon increases the supply of blood and oxygen to the heart. Hydrochlorothiazide is a thiazide-type diuretic drug that is to treat hypertension globally and is comparatively safe. Hydrochlorothiazide performs its action by acting on the distal convoluted tubules of kidneys and inhibiting the sodium chloride cotransporter system. This mechanism results in a diuretic action that decreases blood pressure, but it could also result in a potassium loss in the urine.

Telmisartan, Hydrochlorothiazide

Tablet

Hypertension (High Blood Pressure)

Dose must be taken according to the doctor’s advice only; doses given below are suggested as supportive literature for better understanding in some areas of requirements. Adult dose: For hypertension; At first, one tablet containing 40mg telmisartan/12.5mg hydrochlorothiazide once a day. Dosage range is 80-160mg telmisartan/12.5-25mg hydrochlorothiazide orally a day. Dose must be adjusted according to patient’s condition.

Hemodialysis is not useful in case of Telmisartan overdose; its overdose may cause hypotension. Overdose of hydrochlorothiazide drug will show you the signs of nausea, muscle weakness, extreme dry mouth and thirst and dizziness. Consult your doctor immediately in case of overdose.

In case you missed any dose, take the next dose as soon as you remember, but don't double your next dose to compensate for the missed one.

Take it orally according to your doctor’s advice.

Telmisartan: acts directly on the renin-angiotensin system and can result in injury and death of developing fetus. Do not use hydrochlorothiazide in case of increasing azotemia and oliguria during treatment of severe progressive renal disease. Avoid use of this drug during breastfeeding. Avoid use of diuretics like; hydrochlorothiazide for treatment of increased blood pressure in patients with primary adrenal insufficiency.

Telmisartan: peripheral edema Dizziness Headache Diarrhea Dermal ulcer Abdominal pain Back pain myalgia Upper respiratory tract infections Sinusitis Gastroesophageal reflux disease Hypotension Muscle cramps Hypotension Urticaria Muscle spasm Hypokalemia Hypomagnesemia Hypercalcemia Hyponatremia Hyperuricemia Hypersensitivity reactions Myopia Acute angle-closure glaucoma(reversible)

Telmisartan; angioedema may occur with its use, hyperkalemia (due to renal disk function or concomitant use of potassium sparing diuretics or potassium containing drugs) and hypotension may also occur with its use. Care should be taken in cardiac or renal impaired conditions. Hydrochlrothiazide; Caution is required in gout or gouty arthritis patients as Hydrochlorothiazide may cause hyperuricemia and precipitate gout or gouty arthritis in susceptible patients. Hydrochlorothiazide must be used with extreme caution or avoid hydrochlorothiazide in the management of ascites due to cirrhosis; because hydrochlorothiazide may lead to rapid progression of hyponatremia when used in combination with spironolactone and furosemide. Caution is required while using hydrochlorothiazide in patients with moderate or high cholesterol concentrations; it may increase cholesterol and triglyceride levels. As hydrochlorothiazide reduces calcium excretions so long term use of hydrochlorothiazide may affect normal functioning of parathyroid gland due to development of hypercalcemia and hypophosphatemia. May cause azotemia in patients with impaired renal function. Use with caution in patients with severe liver dysfunction; avoid electrolyte and acid/base imbalances that might lead to liver encephalopathy or coma. May cause changes in glucose control so use with caution in patients with prediabetes or diabetes mellitus. Avoid the use of diuretics like; hydrochlorothiazide in the immediate postoperative period after bariatric surgery because it could lead to electrolyte disturbances and dehydration. Once oral fluid intake becomes normal then this medicine could be resumed after indication. Some preparation of hydrochlorothiazide may contain propylene glycol; in neonates if large amounts of propylene glycol are given orally, intravenously (e.g., >3,000 mg per day), or topically then it may result in fatal toxicities like; metabolic acidosis, seizures, renal failure, and CNS depression; these toxicities could occur in children and adults including hyperosmolality, lactic acidosis, seizures, and respiratory depression; so use with caution. Development of electrolyte disturbances may be minimized when used in combination with other electrolyte-sparing antihypertensive medicines (e.g., angiotensin-converting enzyme, angiotensin receptor blockers, or aldosterone inhibitors).

High-potassium foods must be avoided during use of Telmisartan.

ECG and blood pressure along with use.