MITOMYCIN 2MG INJ KOREA

The mechanism of action of Mitomycin, a chemotherapeutic agent, primarily involves its ability to interfere with DNA synthesis and function. Mitomycin is a DNA cross-linking agent that binds to the DNA duplex, forming both inter• and intra-strand cross-links. This binding occurs primarily at the guanine-cytosine (G-C) rich regions of DNA, causing structural alterations. The cross-linking prevents DNA replication and transcription, leading to cell growth inhibition and cell death. Specifically, mitomycin inhibits the synthesis of deoxyribonucleic acid (DNA) by forming covalent bonds between adjacent strands of DNA, thereby disrupting the DNA helix and blocking the replication process. This action results in the inhibition of cell division and ultimately leads to cell death, particularly in rapidly dividing cells, such as cancer cells.

Antineoplastic agent

Injection

The following are the uses of MITOMYCIN 2MG Injection:

• Used for treating certain types of cancers, particularly stomach, pancreas, and bladder cancers.
• Used for slowing or stopping the growth of cancer cells by interfering with their DNA.
• Used for neoadjuvant therapy to shrink tumors before surgery.
• Used for adjuvant therapy to reduce the risk of cancer recurrence after surgery.
• Used for treating inoperable tumors to control their growth and spread.
• Used for combination therapy with other cancer drugs for enhanced effectiveness.

In the case of an overdose of Mitomycin 2mg Injection, prompt medical attention is necessary. Symptoms of an overdose may include severe nausea, vomiting, diarrhea, and potentially life-threatening conditions such as bone marrow suppression and kidney damage. If an overdose is suspected, seek emergency medical care immediately. The healthcare provider will likely administer supportive measures to manage the patient's symptoms and provide appropriate treatment to address any complications arising from the overdose.

In the case of a missed dose of MITOMYCIN 2MG Injection, it is important to act promptly. If you remember within a few hours of the missed dose, administer the medication as soon as possible. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. Consult your healthcare provider if you have any concerns or if you miss multiple doses.

To administer MITOMYCIN 2MG Injection, reconstitute the powder with the provided sterile diluent, gently swirl the vial to dissolve, and withdraw the prescribed dose using a sterile syringe, then inject it intravenously over 3 to 5 minutes as directed by your healthcare professional.

Following are the conditions when MITOMYCIN 2MG Injection should not be used:

• Must not be used in patients with a known allergy to Mitomycin or any of its components.
• Not suitable for patients with severe bone marrow depression.
• Contraindicated in patients with severe kidney disease or impaired kidney function.
• Should not be used during pregnancy or breastfeeding.
• Avoid in patients with a history of lung or respiratory diseases.
• Not recommended for patients with a known sensitivity to other chemotherapeutic agents.
• Must not be used in patients with a history of radiation therapy to the chest.

The side effects of MITOMYCIN 2MG Injection may include:

• Nausea and vomiting
• Loss of appetite
• Hair loss (alopecia)
• Mouth sores
• Fatigue and weakness
• Darkening of skin and nails
• Low blood cell counts (leading to increased risk of infection, anemia, or bleeding)
• Fever

Following are the precautions and warnings for MITOMYCIN 2MG Injection:

• This medication is for intravenous use only and should be administered by trained healthcare professionals in a controlled medical setting.
• Patients should be closely monitored for potential bone marrow suppression, especially those with pre-existing blood disorders or undergoing radiation therapy.
• It can cause severe myelosuppression, leading to decreased white blood cells, red blood cells, and platelets. Regular blood tests are necessary to monitor blood cell counts.
• Patients may experience nausea and vomiting, and anti-emetics may be prescribed to manage these side effects.
• Urine may temporarily turn a blue-green color for 24 hours after administration, which is a normal effect and not a cause for concern.
• MITOMYCIN should be used with caution in patients with impaired liver or kidney function, as dosage adjustments may be required.
• It is potentially teratogenic, and effective contraception should be used by both male and female patients during and after treatment to prevent pregnancy.
• Patients should be advised to avoid contact with people who have recently received live vaccines, as MITOMYCIN may increase the risk of infection.

Following are the drug interactions for MITOMYCIN 2MG Injection:

• Concomitant use with radiation therapy can enhance the cytotoxic effects of mitomycin, potentially increasing the risk of adverse reactions.
• May interact with bone marrow suppressants, leading to increased myelosuppression and potential severe hematologic toxicity.
• Caution with live vaccines as mitomycin can inhibit the immune response, reducing vaccine effectiveness.
• Use with other nephrotoxic drugs may increase the risk of renal impairment.
• Avoid co-administration with other ototoxic medications, as it may enhance the risk of hearing loss.
• Mitomycin can potentiate the effects of other anticancer agents, requiring careful monitoring.
• Drug interactions with immunosuppressants may lead to increased immunosuppression and potential opportunistic infections.

Following are the food interactions for MITOMYCIN 2MG Injection:

• Avoid consuming grapefruit and grapefruit juice as they may alter the drug's metabolism, potentially increasing the risk of side effects.
• Alcohol consumption should be limited or avoided as it may increase the risk of stomach irritation and other gastrointestinal issues.
• Caffeinated beverages like coffee and tea might enhance the drug's elimination, reducing its effectiveness.
• High-fat meals can delay the absorption of the medication, potentially affecting its therapeutic effect.
• Avoid eating salty or heavily processed foods as they may interact with the medication's effect on blood pressure.
• Consuming a balanced diet rich in fruits, vegetables, and whole grains can support overall health during treatment.
• Ensure adequate fluid intake to maintain hydration, especially if experiencing nausea or vomiting as side effects.

Mitomycin 2MG Injection should be stored in a secure and controlled environment, preferably in a designated pharmaceutical storage area. It should be kept in its original packaging, protected from light and moisture, at a recommended temperature range of 20-25°C (68-77°F). Ensure the injection is stored in a locked cabinet or restricted area to prevent unauthorized access. When disposing of Mitomycin, follow local regulations and guidelines for hazardous waste disposal. Do not dispose of it in regular trash or pour it down the drain; instead, contact a licensed waste disposal company or healthcare facility for proper disposal. It is crucial to handle this medication with care, keeping it out of the reach of children and pets to prevent accidental exposure.

Following are the quick tips for MITOMYCIN 2MG Injection:

• Administer the injection under medical supervision for the treatment of cancer.
• Ensure the injection is prepared and handled by trained medical professionals.
• The injection is typically given into a muscle or vein, as directed by your doctor.
• Follow the prescribed dosage and treatment schedule for the best therapeutic outcome.
• Inform your doctor if you have any allergies or medical conditions before receiving the injection.
• Do not reuse or share needles/syringes to prevent infections and ensure safety.
• Store the injection as directed on the packaging, away from light and moisture.
• Seek immediate medical attention if you experience any severe side effects or allergic reactions.