Mitomycin C (10mg) 1 Vial Injection

Mitomycin, the active ingredient in MITOMYCIN 10mg injection, is an antibiotic derived from Streptomyces caespitosus. Its primary mechanism of action is through the inhibition of DNA synthesis in cells. Mitomycin forms a stable complex with DNA by reacting with adenine and guanine bases, leading to DNA cross-linking. This cross-linking prevents DNA replication and transcription, ultimately resulting in cell death. Specifically, it interferes with the synthesis of the guanine nucleotide, inhibiting the production of essential DNA components and disrupting the cell cycle, particularly during the S-phase. This action primarily affects rapidly dividing cells, making it useful in targeting cancerous and hyperproliferative cells.

Antineoplastic (anti-cancer) antibiotic.

Injection

The following are the uses of MITOMYCIN 10mg injection:

• Used for treating certain types of cancers, particularly stomach, pancreas, and bladder cancers.
• Used for its effectiveness in shrinking tumors and preventing cancer cell growth.
• Used for neoadjuvant therapy to shrink tumors before surgery.
• Used for adjuvant therapy after surgery to reduce the risk of cancer recurrence.
• Used for its ability to target and kill cancer cells directly.
• Used for managing and improving survival rates in specific cancer cases.
• Used for carefully controlled doses to minimize side effects.
• Used for combination with other cancer treatments for enhanced efficacy.

In the case of an overdose of Mitomycin 10mg injection, prompt medical attention is required. Symptoms of an overdose may include severe nausea, vomiting, and diarrhea, as well as a significant decrease in white blood cell count, leading to a higher risk of infection. The patient should be closely monitored for any signs of infection and treated accordingly. Medical professionals should be contacted immediately to provide appropriate supportive care and manage any potential complications.

In the case of a missed dose of Mitomycin 10mg injection, it is important to contact your healthcare provider for guidance. They will be able to advise you on the best course of action, as the decision to take a missed dose or skip it depends on various factors, including the timing of the missed dose and the reason for taking the medication. Your healthcare provider can determine whether you should take the missed dose as soon as possible or simply wait for the next scheduled dose to maintain the treatment's effectiveness and minimize potential side effects.

To administer MITOMYCIN 10mg injection, reconstitute the powder with the provided sterile diluent, gently swirl until completely dissolved, and then inject the entire contents intramuscularly or intravenously as directed by your healthcare professional, ensuring proper aseptic technique and following the recommended dosage guidelines.

Here are the situations when Mitomycin 10mg injection should not be used:

• Should not be administered to patients with a known allergy to Mitomycin or any of its components.
• Contraindicated in individuals with a severe bone marrow depression.
• Not recommended for patients with a known hypersensitivity to other mitomycin derivatives.
• Avoid using in patients with severe kidney or liver disease.
• Should not be used during pregnancy or breastfeeding.
• Contraindicated in patients with a history of pulmonary fibrosis or severe lung disease.
• Not suitable for patients with uncontrolled infections or active infections.

The side effects of MITOMYCIN 10mg injection may include:

• Nausea and vomiting
• Loss of appetite
• Hair loss
• Mouth sores
• Darkened skin and nails
• Fatigue and weakness
• Increased risk of infection
• Allergic reactions (such as rash, itching, or difficulty breathing)

Following are the precautions and warnings for MITOMYCIN 10mg injection:

• This medication should be administered under strict medical supervision due to its potential for severe side effects.
• It is imperative to conduct a thorough evaluation of the patient's medical history, including any previous chemotherapy treatments, before initiating therapy.
• Patients should be closely monitored for signs of bone marrow suppression, as mitomycin can cause a decrease in blood cell counts.
• Regular blood tests are necessary to monitor liver and kidney function, as these organs may be affected.
• Mitomycin may cause severe allergic reactions; emergency medical attention should be sought if symptoms such as rash, itching, or difficulty breathing occur.
• Not recommended for pregnant women due to potential risks to the fetus. Effective contraception is essential during treatment.
• Breastfeeding is not advised while using this medication, as it may pass into breast milk and harm the nursing infant.
• Store the injection securely, out of reach of children and pets, in a cool, dry place.

Following are the drug interactions for Mitomycin 10mg injection:

• Mitomycin may interact with bone marrow suppressants, increasing the risk of myelosuppression and severe infections.
• Use with radiation therapy can result in severe adverse effects, including increased mucosal damage and reduced white blood cell counts.
• Avoid live vaccines during and immediately after Mitomycin treatment to prevent vaccine-related complications.
• Caution is advised when combining with other ototoxic medications, as it may increase the risk of hearing loss.
• Drugs that induce or inhibit cytochrome P450 enzymes may alter Mitomycin metabolism, affecting its efficacy and toxicity.
• Concurrent use with nephrotoxic agents can increase the risk of kidney damage and impaired renal function.
• Mitomycin may reduce the effectiveness of hormonal contraceptives, requiring alternative birth control methods.

Following are the food interactions for Mitomycin 10mg Injection:

• Avoid consuming grapefruit and grapefruit juice as they may influence the metabolism of Mitomycin, potentially altering its effectiveness.
• Alcohol consumption should be limited or avoided as it can increase the risk of gastrointestinal issues and may also affect the liver function during Mitomycin therapy.
• Avoid raw or undercooked meat, fish, and eggs to reduce the risk of foodborne illnesses, as Mitomycin can weaken the immune system.
• Maintain a balanced diet with adequate protein and calories to support the body's nutritional needs during treatment.
• Stay hydrated by drinking plenty of fluids, especially water, to help with hydration and kidney function.
• Consider avoiding spicy or acidic foods if gastrointestinal side effects like nausea or stomach irritation occur.
• Consult a dietician or healthcare provider for personalized dietary recommendations during Mitomycin treatment, especially if experiencing appetite changes or weight loss.

Mitomycin 10mg injection should be stored in a secure and designated pharmaceutical storage area, protected from light and maintained at a controlled room temperature, typically between 20-25°C (68-77°F). It is crucial to keep the injection in its original packaging, ensuring the integrity of the medication. Avoid exposing the injection to freezing temperatures or direct heat sources, as this can compromise its potency. Always check the expiration date before use, and never use the medication if it is expired. When disposing of Mitomycin injection, do not dispose of it via household waste or wastewater. Instead, follow local regulations and guidelines for the safe disposal of pharmaceutical waste, or consult healthcare professionals for appropriate disposal methods to protect the environment and public health. Keep the medication out of reach of children and pets to prevent accidental exposure or ingestion.

Following are the quick tips for Mitomycin 10mg Injection:

• Administer the injection under medical supervision for accurate dosage and proper administration.
• Ensure the injection is prepared and handled by trained medical professionals.
• Mitomycin is typically given as a slow infusion into a vein, and the duration may vary based on the treatment plan.
• Avoid contact with the skin; wear gloves when handling the injection to prevent skin exposure.
• Do not reuse needles, syringes, or other injection materials; dispose of them properly.
• Inform your doctor if you experience any side effects like nausea, vomiting, or skin reactions.
• Store Mitomycin vials in a refrigerator, protected from light, and do not freeze the medication.