Mobicam (15mg/1.5ml) 5 Ampoule Injections

Piroxicam's primary mechanism of action involves inhibiting the cyclooxygenase (COX) enzymes, particularly COX-1 and COX-2, which play a crucial role in the synthesis of prostaglandins. By blocking these enzymes, Piroxicam effectively reduces the production of prostaglandins, which are key mediators of inflammation and pain. This inhibition results in decreased inflammation, reduced pain perception, and lower fever by interfering with the normal functioning of prostaglandins in various tissues throughout the body. Piroxicam's selective inhibition of COX enzymes contributes to its anti-inflammatory, analgesic, and antipyretic effects, making it useful in the management of conditions where these symptoms are prominent.

Nonsteroidal anti-inflammatory drug (NSAID)

injection

The following are the uses of Piroxicam injection:

• Used for relieving severe pain and inflammation, particularly in conditions like rheumatoid arthritis and osteoarthritis.
• Used for managing acute pain post-surgery or due to injuries.
• Used for reducing swelling and stiffness in joints, improving mobility.
• Used for treating ankylosing spondylitis, a type of arthritis affecting the spine.
• Used for providing rapid relief in gout attacks.
• Used for controlling pain and inflammation in soft tissue injuries.
• Used for offering short-term pain management in certain chronic conditions.
• Used for alleviating discomfort and improving quality of life in various painful conditions.

In the case of an overdose of Piroxicam injection, it is crucial to act promptly. Seek immediate medical assistance and inform the healthcare provider about the amount of medication administered. Symptoms of an overdose may include severe stomach pain, persistent nausea, and vomiting. Quick intervention can help manage these symptoms and prevent potential complications. Always store medications safely and follow dosage instructions to minimize the risk of accidental overdoses.

In the case of a missed dose of Piroxicam injection, it is important to act promptly. If you remember within a few hours of the missed dose, administer the injection as soon as possible. However, if a significant amount of time has passed, or if it is close to the time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Never double the dose to make up for a missed one, as this may increase the risk of side effects. Consult your healthcare provider if you have any concerns or questions about missed doses.

To administer the Piroxicam injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, and slowly inject the prescribed dose subcutaneously, ensuring the entire medication is delivered before withdrawing the needle.

Here are the conditions or situations when Piroxicam injection should not be used:

• Must not be used in patients with a known allergy or hypersensitivity to Piroxicam or other non-steroidal anti-inflammatory drugs (NSAIDs).
• Contraindicated in patients with active gastrointestinal bleeding or a history of gastrointestinal bleeding, perforation, or ulcers.
• Should not be administered to individuals who have recently undergone coronary artery bypass graft (CABG) surgery.
• Not recommended for patients with severe heart failure or heart disease.
• Avoid in patients with severe kidney impairment or those at risk of renal failure.
• Not suitable for individuals with a history of bronchial asthma, especially those with NSAID-induced asthma.
• Contraindicated in pregnant women, especially during the third trimester.
• Should not be used in nursing mothers due to potential risk to the infant.
• Avoid in patients with known or suspected cerebrovascular bleeding or other bleeding disorders.
• Not recommended for individuals with severe dehydration or low fluid volume status.

The side effects of Piroxicam injection may include:

• Stomach pain or discomfort
• Nausea and vomiting
• Diarrhea
• Dizziness or lightheadedness
• Headache
• Skin rash or itching
• Increased blood pressure
• Kidney problems

Following are the precautions and warnings for Piroxicam injection:

• Allergic reactions may occur; individuals with a known history of allergy to NSAIDs or any components of the injection should not use it.
• Piroxicam can cause gastrointestinal bleeding, ulceration, and perforation, which can be severe and life-threatening. Patients with a history of gastrointestinal issues should use with caution.
• Kidney function should be monitored regularly during treatment, especially in patients with pre-existing kidney disease.
• It may cause an increased risk of cardiovascular events such as heart attack or stroke. Patients with cardiovascular disease or risk factors should use it with caution.
• Elderly patients are more prone to adverse reactions and should be closely monitored during treatment.
• Not recommended for use in children and adolescents under 18 years of age.
• Women who are pregnant or breastfeeding should consult their healthcare provider before using Piroxicam, as it may have adverse effects on the fetus and infant.

Following are the drug interactions for Piroxicam injection:

• Avoid using Piroxicam with other non-steroidal anti-inflammatory drugs (NSAIDs) as it may increase the risk of gastrointestinal bleeding and kidney problems.
• ACE inhibitors and angiotensin receptor blockers (ARBs) can have decreased effectiveness when used with Piroxicam, potentially leading to reduced blood pressure control.
• Lithium levels in the blood may be increased when used with Piroxicam, requiring close monitoring.
• Piroxicam may reduce the elimination of methotrexate, increasing its toxicity risk. Regular monitoring is advised.
• When combined with diuretics, Piroxicam can reduce their diuretic and antihypertensive effects.
• Anticoagulants like warfarin may have their effects enhanced, increasing the risk of bleeding.
• Thrombolytic agents may have their effects potentiated, requiring close monitoring.

Following are the food interactions for Piroxicam injection:

• Avoid excessive alcohol consumption during treatment, as it can increase the risk of gastrointestinal bleeding and liver toxicity.
• Grapefruit and grapefruit juice should be consumed with caution as they may interfere with the metabolism of Piroxicam, leading to increased drug levels in the body.
• Limit caffeine intake as it can enhance the effects of Piroxicam on the central nervous system, potentially causing increased nervousness and insomnia.
• Avoid high-sodium foods, as Piroxicam can cause sodium and fluid retention, especially in patients with heart or kidney issues.
• Inform your doctor if you have a history of allergies to any food, as Piroxicam may cause allergic reactions in some individuals.
• No specific food restrictions are necessary, but a balanced diet is recommended to maintain overall health.
• Avoid fatty or greasy foods as they may delay the absorption of Piroxicam.
• Always consult your healthcare provider for personalized advice regarding dietary restrictions and interactions with Piroxicam injection.

Piroxicam injection should be stored in a controlled environment, preferably between 68°F and 77°F (20°C and 25°C), with excursions permitted between 59°F and 86°F (15°C and 30°C). Protect the injection from light and do not freeze it. Keep the medication in its original packaging until use to maintain its integrity. Once opened, use the injection promptly, and do not store any unused portions. Disposal of unused or expired piroxicam injection should be done in accordance with local regulations and guidelines. Contact your healthcare provider or pharmacist for advice on proper disposal methods to ensure environmental safety. Keep the medication out of the reach of children and pets to prevent accidental exposure.

Following are the quick tips for Piroxicam injection:

• Piroxicam injection should be administered by a healthcare professional in a medical setting.
• Inform your doctor about your medical history, especially any liver or kidney issues.
• Provide a list of all medications you are taking to avoid potential interactions.
• Avoid injecting near nerves or blood vessels; follow the prescribed injection site.
• Do not reuse needles or syringes; dispose of them safely after use.
• Report any signs of allergic reaction or severe side effects immediately.
• Store the injection as directed on the package, away from direct sunlight and moisture.
• Ensure you complete the full course of treatment as prescribed by your doctor.