Modipran (20mg) 100 Capsules

Fluoxetine Hydrochloride 20mg Capsule works by inhibiting the reuptake of serotonin, a neurotransmitter, in the brain. This selective inhibition increases the levels of serotonin in the synaptic cleft, enhancing neurotransmission and improving mood, anxiety, and other symptoms related to depression and anxiety disorders. Fluoxetine is a selective serotonin reuptake inhibitor (SSRI), which means it specifically targets serotonin rather than other neurotransmitters, minimizing side effects compared to older antidepressants. The increased serotonin availability helps regulate mood, reduce anxiety, and improve symptoms associated with conditions like depression, OCD, and panic disorders.

Fluoxetine Hydrochloride 20mg

Selective Serotonin Reuptake Inhibitors (SSRIs)

Capsule

The following are the uses of Fluoxetine Hydrochloride 20mg Capsule:

• Treatment of major depressive disorder in adults and children aged 8 years and older.
• Management of generalized anxiety disorder (GAD) in adults.
• Treatment of obsessive-compulsive disorder (OCD) in adults and children aged 7 years and older.
• Management of panic disorder with or without agoraphobia.
• Treatment of premenstrual dysphoric disorder (PMDD) in women.
• Management of bulimia nervosa (as part of a comprehensive treatment plan).
• Treatment of social anxiety disorder (SAD) in adults.
• As an adjunctive treatment for treatment-resistant depression, alongside other medications.

Following are the doses of Fluoxetine Hydrochloride 20mg Capsule:

• The usual dose for adults with depression or anxiety is 20mg once daily, taken in the morning, with or without food.
• For patients with severe depression or anxiety, the dose may be increased by the healthcare provider, but typically not exceeding 60mg per day.
• The starting dose for children (aged 8-18) with depression is generally 10mg once daily, which may be gradually increased based on the response and tolerability.
• For patients with a history of liver issues, a lower starting dose may be recommended, and dosage adjustments may be required.

In case of overdose of Fluoxetine Hydrochloride 20mg Capsule, immediate medical attention should be sought. Symptoms of overdose may include nausea, vomiting, drowsiness, rapid heartbeat, tremors, confusion, seizures, or serotonin syndrome (e.g., agitation, hallucinations, fever, muscle stiffness). It is important not to induce vomiting or take any other actions without consulting a healthcare provider.

If you miss a dose of Fluoxetine Hydrochloride 20mg Capsule, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at the same time to make up for the missed dose, as this could increase the risk of side effects. Always follow the dosing instructions provided by your healthcare provider and consult them if you're unsure about how to proceed after missing a dose.

To use Fluoxetine Hydrochloride 20mg Capsule, follow the instructions provided by your healthcare provider or as indicated on the prescription label. Typically, it should be taken once daily, with or without food. Swallow the capsule whole with a glass of water. Do not chew, crush, or break the capsule. It's important to take the medication at the same time each day to help you remember and maintain consistent levels in your body.

Following are the situations when Fluoxetine Hydrochloride 20mg Capsule should not be used:

• Should not be used in individuals with a known allergy to Fluoxetine or any of its components.
• Contraindicated in patients who are currently taking monoamine oxidase inhibitors (MAOIs) or have recently stopped taking them within the last 14 days.
• Should not be used in individuals with a history of serotonin syndrome, as Fluoxetine may increase the risk of this potentially life-threatening condition.
• Not recommended for use in patients with uncontrolled epilepsy or a history of seizures, as Fluoxetine may lower the seizure threshold.
• Should not be used in individuals with a history of manic episodes or bipolar disorder unless closely monitored by a healthcare provider.

The side effects of Fluoxetine Hydrochloride 20mg Capsule may include:

• Nausea
• Headache
• Insomnia
• Drowsiness
• Dry mouth
• Loss of appetite
• Sweating
• Sexual dysfunction (e.g., decreased libido, erectile dysfunction)
• Weight changes
• Anxiety or nervousness
• Dizziness
• Diarrhea
• Tremors
• Increased risk of suicidal thoughts or behaviors (especially in younger adults)

Following are the precautions and warnings for Fluoxetine Hydrochloride 20mg Capsule:

• Should not be used in individuals with a known allergy to Fluoxetine or any of its components.
• Contraindicated in patients who are currently taking monoamine oxidase inhibitors (MAOIs) or have recently stopped taking them within the last 14 days.
• Caution is advised in patients with a history of bipolar disorder, as Fluoxetine may trigger manic episodes.
• Should be used with caution in individuals with a history of seizures, as Fluoxetine may lower the seizure threshold.
• Not recommended for use in individuals with a history of suicidal thoughts or behaviors, particularly in younger adults, as Fluoxetine may increase the risk of suicide.
• Caution is needed for patients with liver disease, as Fluoxetine is metabolized in the liver and may lead to liver toxicity in individuals with impaired liver function.
• Should be used with caution in individuals with a history of bleeding disorders or those taking anticoagulants, as Fluoxetine may increase the risk of bleeding.
• Caution is advised when using Fluoxetine with other serotonergic drugs to avoid the risk of serotonin syndrome.

Following are the drug interactions for Fluoxetine Hydrochloride 20mg Capsule:

• Concomitant use with other serotonergic drugs (e.g., other SSRIs, SNRIs, triptans, or certain pain medications) can increase the risk of serotonin syndrome, a potentially life-threatening condition.
• Use with monoamine oxidase inhibitors (MAOIs) is contraindicated, as it may lead to serious, sometimes fatal reactions such as serotonin syndrome.
• Fluoxetine may interact with anticoagulants like warfarin, increasing the risk of bleeding. Monitoring of coagulation parameters is recommended.
• Caution is advised when combining Fluoxetine with other medications that affect the central nervous system (e.g., benzodiazepines, alcohol), as this can enhance sedative effects and impair judgment.
• Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen or aspirin, may increase the risk of bleeding when taken with Fluoxetine.
• Fluoxetine may increase blood levels of certain medications metabolized by the liver, including some anticonvulsants and antipsychotics, potentially increasing the risk of side effects.
• Caution is advised when using Fluoxetine with certain medications that affect liver enzymes, as this may alter the metabolism of Fluoxetine.

Following are the food interactions for Fluoxetine Hydrochloride 20mg Capsule:

• Alcohol should be avoided while taking Fluoxetine, as it can increase the risk of side effects like drowsiness, dizziness, and impaired judgment.
• Grapefruit and grapefruit juice should be consumed with caution, as they may increase the levels of Fluoxetine in the blood, potentially raising the risk of side effects.
• There are no significant direct food interactions with Fluoxetine, but it may be helpful to take it with food if it causes stomach upset.

Fluoxetine Hydrochloride 20mg Capsule should be stored in a cool, dry place, away from direct sunlight and moisture. The ideal storage temperature is between 20°C to 25°C (68°F to 77°F). Keep the medication in its original container, tightly closed, and out of reach of children to prevent accidental ingestion. Do not store the medication in the bathroom, as humidity may affect its quality. If you need to dispose of Fluoxetine, do not flush it down the toilet or throw it in the trash. Consult your healthcare provider or pharmacist for guidance on safe disposal methods to ensure proper disposal and prevent misuse.

Following are the quick tips for Fluoxetine Hydrochloride 20mg Capsule:

• Take Fluoxetine exactly as prescribed by your healthcare provider for the best results.
• Take the medication in the morning to help avoid insomnia, unless instructed otherwise by your healthcare provider.
• Swallow the capsule whole with a glass of water; do not chew, crush, or break it.
• It may take several weeks to notice the full effect of Fluoxetine, so continue taking it as prescribed, even if you feel better.
• Do not stop taking Fluoxetine suddenly without consulting your healthcare provider to avoid withdrawal symptoms.
• Avoid alcohol while taking Fluoxetine, as it may increase the risk of side effects such as dizziness or drowsiness.
• If you experience any mood changes or thoughts of self-harm, seek immediate medical help.

Fluoxetine Hydrochloride 20mg Capsule does not typically require routine lab screening or monitoring. However, in certain cases, especially for patients with underlying health conditions or those at higher risk of side effects, the following may be considered:

• Periodic liver function tests, as Fluoxetine can potentially cause liver damage, especially in individuals with pre-existing liver conditions.
• Regular psychiatric evaluations, as Fluoxetine may increase the risk of suicidal thoughts and behaviors, particularly in younger adults.
• Monitoring of electrolyte levels and kidney function in patients at risk of electrolyte imbalances.
• Regular blood pressure monitoring in patients with a history of hypertension, as Fluoxetine may cause changes in blood pressure.
• Routine monitoring for signs of serotonin syndrome (e.g., agitation, hallucinations, fever, muscle twitching) when taken with other serotonergic medications.