Monis XR (60mg) 30 Tablets

Isosorbide, the active ingredient in the 60mg tablet, primarily exerts its therapeutic effects through vasodilation. It acts as a vasodilator by inhibiting the enzyme phosphodiesterase, leading to increased levels of cyclic adenosine monophosphate (cAMP) in smooth muscle cells. This rise in cAMP causes relaxation of the vascular smooth muscles, particularly in the coronary arteries and peripheral vasculature. By promoting vasodilation, isosorbide enhances blood flow, improves oxygen delivery to the heart, and reduces the workload on the heart, thereby alleviating angina symptoms and providing relief in conditions where improved blood circulation is required.

Isosorbide 60mg

Nitrate vasodilator.

Tablet

The following are the uses of Isosorbide 60mg Tablet:

• Used for treating heart failure and reducing the risk of hospitalization due to heart-related issues.
• Used to lower blood pressure, especially in patients with hypertension.
• Used for managing angina (chest pain) and improving blood flow to the heart.
• Used in the treatment of coronary artery disease to enhance blood circulation.
• Used to prevent blood clots and reduce the risk of heart attack or stroke.
• Used to improve exercise capacity in individuals with cardiovascular conditions.
• Used for long-term management of cardiovascular health and maintaining heart function.

To be taken as per doctor's prescription

In the case of an overdose of Isosorbide 60mg Tablets, individuals may experience symptoms such as severe headaches, dizziness, fainting, and a sudden drop in blood pressure. It is important to recognize that an overdose can lead to life-threatening complications. If you suspect an overdose, seek medical assistance promptly. Quick action is vital as it allows for timely treatment and reduces the risk of severe health consequences associated with excessive Isosorbide intake.

In the case of a missed dose of Isosorbide 60mg Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or asking someone to remind you to take your medication as prescribed to ensure the best therapeutic outcome.

To take Isosorbide 60mg Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, following the dosage instructions provided by your doctor, typically once or twice daily, without crushing or chewing the tablet.

Following are the conditions when Isosorbide 60mg Tablet should not be used:

• Avoid using this medication if you have a history of severe allergic reactions to Isosorbide or other similar medications.
• Do not take this tablet if you have or have had a recent heart attack, severe heart failure, or low blood pressure.
• Contraindicated in individuals with severe liver or kidney disease.
• Should not be used if you have a head injury, brain hemorrhage, or increased intracranial pressure.
• Not suitable for individuals with closed-angle glaucoma.
• Do not take this medication if you have a blood disorder or severe anemia.
• Avoid if you have had a recent stroke.
• Should not be used if you have a known allergy to nitrates.

The side effects of Isosorbide 60mg Tablet may include:

• Headache
• Dizziness
• Nausea and vomiting
• Fatigue or weakness
• Blurred vision
• Flushing (warmth or redness of the skin)
• Skin rash or itching
• Palpitations or irregular heartbeat

Following are the precautions and warnings for Isosorbide 60mg Tablet:

• Do not take this medication if you are allergic to isosorbide or any other nitrates. Severe reactions may occur.
• This medication is intended for oral use only. Do not crush, chew, or dissolve the tablet, as it has a specialized coating for controlled release.
• Exercise caution if you have a history of hypotension (low blood pressure) as this drug may further lower your blood pressure.
• Patients with glaucoma should be monitored as this medication can increase intraocular pressure.
• Isosorbide may cause dizziness or lightheadedness. Avoid driving or operating heavy machinery until you know how this medication affects you.
• Inform your doctor if you have liver or kidney disease, as the dosage may need to be adjusted.
• Alcohol consumption should be avoided as it may increase the risk of side effects and may also lower blood pressure.

Following are the drug interactions for Isosorbide 60mg Tablet:

• Concurrent use with other nitrates or nitric oxide donors can lead to excessive vasodilation and severe hypotension.
• Sildenafil and similar phosphodiesterase-5 inhibitors may cause a significant drop in blood pressure when taken with Isosorbide.
• The hypotensive effects can be intensified when used with antihypertensive medications, such as beta-blockers or ACE inhibitors.
• Isosorbide may interact with calcium channel blockers, leading to increased risk of hypotension and reflex tachycardia.
• Alcohol consumption can potentiate the hypotensive effects of Isosorbide, potentially causing dizziness and fainting.
• Certain medications like ergot alkaloids may interact, leading to increased vasoconstriction and potential ischemia.
• Sympathomimetic agents can counteract the vasodilating effects of Isosorbide, reducing its efficacy.

Following are the food interactions for Isosorbide 60mg Tablet:

• Avoid consuming large amounts of grapefruit or grapefruit juice as it can interfere with the metabolism of Isosorbide, leading to increased drug levels in the blood.
• Alcohol consumption should be limited or avoided as it can cause a sudden drop in blood pressure, especially when combined with Isosorbide.
• Avoid high-sodium foods, as sodium can counteract the blood pressure-lowering effects of Isosorbide, reducing its effectiveness.
• Potassium-rich foods like bananas, oranges, and spinach should be consumed in moderation as they may interact with Isosorbide, affecting heart rhythm.
• Limit caffeine intake from coffee, tea, or energy drinks as it can increase heart rate and blood pressure, working against the effects of Isosorbide.
• Avoid aged, fermented, or smoked meats and cheeses, as they contain high levels of tyramine, which can cause a sudden increase in blood pressure.
• Avoid energy drinks and herbal supplements containing licorice root, as it can lead to potassium depletion and increased blood pressure.
• Always stay well-hydrated by drinking enough water to maintain blood volume and support the medication's effectiveness.

Isosorbide 60mg Tablets should be stored in a secure and dry location, preferably in their original container, away from direct sunlight, moisture, and heat. Keep the tablets in a cool, temperature-controlled environment, as extreme heat or cold can impact their effectiveness. Ensure the container is tightly sealed to maintain the medication's integrity and prevent contamination. Regularly check the expiration date, and dispose of any unused or expired tablets promptly. Do not flush or pour them down the drain; instead, follow local guidelines or consult a pharmacist for safe disposal methods. It is crucial to keep the medication out of children's reach to prevent accidental consumption. Proper storage and disposal practices ensure the safety and efficacy of Isosorbide tablets.

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Following are the quick tips for Isosorbide 60mg Tablet:

• Consult your doctor before use, especially if you have heart or liver problems.
• Take the tablet as directed by your doctor, typically 2-3 times a day.
• Do not crush or chew the tablet; swallow it whole with water.
• Maintain a consistent dosing schedule for better effectiveness.
• Avoid grapefruit and grapefruit juice while taking this medication.
• Inform your doctor about all medications you are currently taking.
• Store the tablets in a cool, dry place, away from direct sunlight.
• Do not share your medication with others, even if they have similar symptoms.