Monocef-O 50 (18g) 30ml Suspension

Cefpodoxime proxetil, the active ingredient in Cefpodoxime 18g Syrup/Suspension, is a third-generation cephalosporin antibiotic. Its mechanism of action involves binding to and inhibiting penicillin-binding proteins (PBPs) located inside bacterial cells. PBPs are essential for the cross-linking of peptidoglycan strands, which form the bacterial cell wall. By inhibiting these enzymes, cefpodoxime disrupts the synthesis of the bacterial cell wall, leading to cell lysis and bacterial death. This selective activity against bacterial cell wall synthesis makes cefpodoxime effective against a wide range of Gram-positive and Gram-negative bacteria, including common pathogens like Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis.

Cefpodoxime 18g

Cephalosporin antibiotic.

Suspension

The following are the uses of Cefpodoxime 18g Syrup/Suspension:

• Used for treating bacterial infections, particularly those affecting the respiratory tract, such as pneumonia, bronchitis, and sinusitis.
• Used for managing skin and soft tissue infections, including cellulitis and impetigo.
• Effective against a wide range of bacteria, including Streptococcus, Staphylococcus, and Haemophilus species.
• Useful in treating acute otitis media, a common ear infection in children.
• Helps manage urinary tract infections (UTIs) caused by susceptible bacteria.
• Provides an alternative for patients allergic to penicillin, offering a broader spectrum of coverage.

In the case of an overdose of Cefpodoxime 18g Syrup/Suspension, the severity of symptoms may vary depending on the amount ingested. Common symptoms can include nausea, vomiting, and diarrhea, but more serious effects like seizures, rapid heart rate, and difficulty breathing may occur. Prompt medical attention is required, as treatment may involve gastric lavage, administration of activated charcoal, and supportive care to manage symptoms and ensure the patient's stability.

In the case of a missed dose of Cefpodoxime 18g Syrup/Suspension, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to get back on track with your medication regimen.

To administer Cefpodoxime 18g Syrup/Suspension, shake the bottle well, then use a measuring device like a marked syringe or spoon to ensure an accurate dose, and give it to your child as directed by your healthcare provider, either with or without food, following the prescribed dosage instructions.

Following are the conditions/situations when Cefpodoxime 18g Syrup/Suspension should not be used:

• Do not use if the patient has a known allergy to Cefpodoxime or any other cephalosporin antibiotics.
• Avoid in patients with a history of severe allergic reactions to penicillin, as cross-reactivity may occur.
• Not suitable for patients with severe kidney disease or those undergoing dialysis.
• Should not be used in patients with a history of gastrointestinal diseases, especially colitis.
• Contraindicated in patients with a history of seizures or other neurological disorders.
• Do not administer to infants below 6 months of age.
• Avoid using Cefpodoxime suspension if the patient is unable to take oral medication or has difficulty swallowing.

The side effects of Cefpodoxime 18g Syrup/Suspension may include:

• Diarrhea
• Nausea and vomiting
• Abdominal pain or discomfort
• Skin rash or itching
• Headache
• Dizziness
• Vaginal yeast infection
• Allergic reactions (rare) such as hives, swelling, or difficulty breathing.

Following are the precautions and warnings for Cefpodoxime 18g Syrup/Suspension:

• This medication should not be used in individuals with a known allergy to Cefpodoxime or any other similar antibiotics.
• Patients with a history of gastrointestinal diseases, especially colitis, should exercise caution and inform their healthcare provider before use.
• Cefpodoxime may cause diarrhea, and if it becomes severe or persistent, it could indicate a more serious condition. Medical attention should be sought if this occurs.
• Patients with kidney or liver problems should inform their doctor, as dosage adjustments might be necessary.
• Avoid using this medication if you are pregnant or breastfeeding without consulting a healthcare professional.
• Cefpodoxime may reduce the effectiveness of birth control pills, so alternative contraceptive methods are recommended.
• Always complete the full prescribed course of the medication, even if symptoms improve, to ensure the infection is completely treated.
• Keep this medication out of reach of children and store it at room temperature, away from direct sunlight and moisture.

Following are the drug interactions for Cefpodoxime 18g Syrup/Suspension:

• Probenecid, a drug used to treat gout, can decrease the excretion of Cefpodoxime, leading to higher drug levels in the body.
• Antacids containing aluminum or magnesium can reduce the absorption of Cefpodoxime when taken simultaneously, so it's best to separate their administration by a few hours.
• Cefpodoxime may decrease the effectiveness of hormonal contraceptives, so alternative or additional contraceptive methods are recommended.
• Drugs that reduce stomach acidity, such as proton pump inhibitors (PPIs) or H2-receptor blockers, can lower the absorption of Cefpodoxime.
• The effectiveness of Cefpodoxime may be reduced when used with other antibiotics like chloramphenicol or macrolides.
• Nephrotoxic drugs, such as nonsteroidal anti-inflammatory drugs (NSAIDs) or aminoglycosides, can increase the risk of kidney problems when used with Cefpodoxime.
• Methotrexate levels may be increased when used with Cefpodoxime, potentially leading to more side effects.

Following are the food interactions for Cefpodoxime 18g Syrup/Suspension:

• Cefpodoxime should be taken with food, preferably at the beginning of a meal, to enhance its absorption and reduce the risk of gastrointestinal side effects.
• Avoid consuming large amounts of calcium-rich foods like dairy products or calcium-fortified juices immediately after taking Cefpodoxime, as calcium can interfere with the absorption of the antibiotic.
• Grapefruit and grapefruit juice are known to interact with some medications, but there is no specific interaction reported with Cefpodoxime. However, it's best to avoid excessive consumption to prevent any potential interference.
• Alcohol may not directly interact with Cefpodoxime, but it's generally recommended to avoid or limit alcohol consumption during treatment to ensure the medication's effectiveness and reduce the risk of side effects.
• There is no specific interaction with caffeine, but it's advisable to maintain moderate caffeine intake to avoid potential stomach irritation, especially if you have a sensitive stomach.
• Foods high in vitamin K, such as leafy green vegetables, should be consumed consistently to maintain stable blood clotting factors, as Cefpodoxime may interfere with vitamin K metabolism.
• No significant interactions with herbal supplements have been reported, but it's always best to inform your healthcare provider about any herbal remedies you are taking.
• Always follow the dosage instructions provided by your healthcare professional, and ensure you complete the full course of the medication for optimal effectiveness.

Cefpodoxime 18g Syrup/Suspension should be stored in a cool and dry environment, preferably at room temperature, ensuring protection from direct sunlight and moisture. The medication must be kept in its original container with a tight seal to maintain its integrity. It is crucial to refrain from exposing it to heat sources like radiators or stoves, as temperature fluctuations can impact its effectiveness. Prioritize disposing of any unused or expired medication appropriately; refrain from flushing it or pouring it down the drain. Consult your pharmacist or healthcare professional for guidance on proper disposal methods. Additionally, exercise caution by keeping the medication out of children's reach to prevent unintended consumption.

Following are the quick tips for Cefpodoxime 18g Syrup/Suspension:

• Always follow your doctor's prescription for the best results.
• Shake the bottle vigorously before each use to ensure proper mixing.
• Administer the syrup with water; avoid tea, coffee, or dairy to enhance absorption.
• Maintain a consistent dosing schedule for better effectiveness and memory.
• If stomach irritation occurs, consider taking it with food or after meals.
• Store the syrup safely away from children to prevent accidental consumption.
• Consult your doctor if symptoms persist or worsen during treatment.
• Inform your healthcare provider about any allergies or medical conditions.