MOSCAL TAB (20S)

Mesalazine 800mg tablets primarily exert their therapeutic effects through the inhibition of cyclooxygenase (COX) enzymes, particularly COX-2, in the gastrointestinal tract. This mechanism leads to a reduction in the production of prostaglandins and other inflammatory mediators. Mesalazine is metabolized in the intestinal mucosa to its active form, 5-aminosalicylic acid (5-ASA), which has potent anti-inflammatory properties. It is believed that 5-ASA inhibits the activation of nuclear factor-kappa B (NF-κB), a key transcription factor involved in the expression of various pro-inflammatory genes. By suppressing NF-κB activation, Mesalazine downregulates the production of inflammatory cytokines, chemokines, and adhesion molecules, thereby reducing inflammation in the intestinal mucosa. Additionally, Mesalazine may also modulate immune responses and enhance the integrity of the intestinal epithelial barrier, contributing to its overall anti-inflammatory action.

Anti-inflammatory (aminosalicylate).

Tablet

The following are the uses of Mesalazine 800mg Tablet:

• Used for managing and controlling inflammation in the colon and rectum, providing relief from symptoms of ulcerative colitis and proctitis.
• Used for maintaining remission in ulcerative colitis, reducing the frequency of flare-ups.
• Used for treating Crohn's disease, particularly in the small intestine and colon, to decrease inflammation and manage symptoms.
• Used for healing and preventing the recurrence of inflammatory bowel disease (IBD) lesions in the intestines.
• Used for reducing pain, rectal bleeding, and diarrhea associated with IBD.
• Used for improving overall well-being and quality of life in patients with IBD.
• Used for local action in the intestines, minimizing systemic side effects.

In the case of an overdose of Mesalazine 800mg Tablets, it is important to recognize the potential symptoms. These may include nausea, vomiting, diarrhea, and abdominal pain. If an overdose is suspected, seeking medical advice promptly is recommended. The healthcare provider may suggest supportive measures such as monitoring vital signs and ensuring adequate hydration. Timely intervention can help manage any adverse effects and ensure the patient's well-being.

In the case of a missed dose of Mesalazine 800mg Tablet, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose to maintain a consistent medication schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen. It is important to follow the prescribed dosage instructions for optimal treatment results.

To take Mesalazine 800mg Tablet, swallow the tablet whole with a full glass of water, preferably with food, once or twice a day as directed by your healthcare professional, ensuring you follow the prescribed dosage and treatment duration for optimal results.

Following are the conditions or situations when Mesalazine 800mg Tablet should not be taken:

• Should not be used in individuals with a known allergy or hypersensitivity to Mesalazine or any of the excipients in the tablet.
• Contraindicated in patients with a history of kidney or liver disease, as it may worsen these conditions.
• Not suitable for individuals with a history of blood disorders or porphyria.
• Should be avoided in patients with a history of heart disease or blood vessel problems.
• Should not be used if there is a blockage or obstruction in the gastrointestinal tract.
• Contraindicated during the last trimester of pregnancy, as it may affect fetal development.
• Not recommended for children under 2 years of age due to potential risks.

The side effects of Mesalazine 800mg Tablet may include:

• Nausea and vomiting
• Stomach pain or cramps
• Diarrhea
• Headache
• Dizziness
• Skin rash or itching
• Hair loss
• Joint pain

Following are the precautions and warnings for Mesalazine 800mg Tablet:

• Patients with known hypersensitivity or allergy to Mesalazine or any of its components should not take this medication.
• Regular monitoring of kidney and liver function is necessary during long-term treatment with Mesalazine.
• Patients with kidney or liver impairment may require dosage adjustments, and close supervision is advised.
• Caution is advised in individuals with a history of asthma or allergic conditions, as Mesalazine may trigger or worsen these conditions.
• Avoid using Mesalazine if you have a gastrointestinal blockage or a history of perforated intestine.
• If you experience any blood-related disorders, such as anemia or blood abnormalities, consult your doctor immediately.
• Mesalazine may cause dizziness or blurred vision; avoid driving or operating machinery until you know how this medication affects you.
• Pregnant and breastfeeding women should consult their doctor before taking Mesalazine, as its effects on the fetus and infant are not fully established.

Following are the drug interactions for Mesalazine 800mg Tablet:

• Sulfasalazine may reduce the absorption of Mesalazine, leading to decreased effectiveness.
• Mesalazine can potentially reduce the effectiveness of azathioprine and 6-mercaptopurine, requiring close monitoring of therapeutic levels.
• There may be an increased risk of bleeding when taken with anticoagulants like warfarin, requiring regular monitoring of coagulation parameters.
• It may interact with certain antibiotics like sulfamethoxazole/trimethoprim, potentially increasing the risk of adverse effects.
• The effectiveness of Mesalazine can be reduced by cholestyramine, which may bind to the drug in the gastrointestinal tract.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) might increase the risk of gastrointestinal side effects when used concurrently.
• Probenecid may increase the blood levels of Mesalazine, potentially leading to increased side effects.

Following are the food interactions for Mesalazine 800mg Tablet:

• Mesalazine absorption can be affected by high-fat meals, which may decrease its effectiveness. It is recommended to take the medication on an empty stomach, at least 1 hour before or 2 hours after a meal.
• Dairy products like milk, yogurt, and cheese can potentially interfere with the absorption of Mesalazine. Consider separating dairy intake from medication timing.
• Avoid grapefruit and grapefruit juice as they may affect the metabolism of Mesalazine, leading to increased blood levels and potential side effects.
• Alcohol consumption is generally not recommended with Mesalazine as it may increase the risk of gastrointestinal irritation and liver-related issues.
• Spicy foods can potentially trigger or worsen gastrointestinal symptoms, especially in individuals with inflammatory bowel disease.
• High-fiber foods might impact the absorption of Mesalazine. Ensure you maintain a consistent fiber intake as advised by your healthcare provider.
• Staying well-hydrated is essential when taking Mesalazine to support overall gastrointestinal health and medication effectiveness.

Mesalazine 800mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. The medication packaging should be kept tightly sealed to maintain its integrity. It is crucial not to store the tablets in the bathroom or near heat-emitting appliances to prevent degradation. Always check the expiration date, and if the tablets have passed their expiry, do not flush them or dispose of them in the drain. For proper disposal methods, consult a pharmacist or healthcare professional. Keep the medication away from children to prevent accidental consumption.

Following are the quick tips for Mesalazine 800mg Tablet:

• Take the tablet as directed by your doctor, usually 2-4 times daily with meals.
• Swallow the tablet whole; do not crush, chew, or break it.
• Maintain a consistent daily dose timing for best results.
• Drink plenty of fluids while taking this medication.
• If you experience nausea, taking the tablet with food may help.
• Do not stop taking the medication without consulting your doctor.
• Store the tablets in a cool, dry place, away from direct sunlight.