Mosegor (0.25mg/5ml) 60ml Syrup

Pizotifen primarily acts as a serotonin antagonist, particularly at 5-HT2 receptors, which are found in various parts of the brain, including the cerebral cortex, hippocampus, and blood vessels. By blocking these receptors, pizotifen inhibits serotonin-induced vasodilation, which is believed to contribute to its effectiveness in preventing migraine attacks. This mechanism helps to reduce the severity and frequency of migraines by modulating the activity of serotonin, a neurotransmitter involved in pain perception and vascular regulation. Pizotifen's action at 5-HT2 receptors is thought to be a key factor in its therapeutic effects in migraine prophylaxis.

Antihistamine

Suspension

The following are the uses of Pizotifen Syrup/Suspension:

• Used for preventing and treating migraine headaches, especially in children.
• Used to reduce the frequency and severity of migraine episodes.
• Used for alleviating symptoms like nausea and vomiting associated with migraines.
• Used to prevent cluster headaches and reduce their intensity.
• Used to treat allergic conditions like hay fever, providing relief from symptoms.
• Used to manage vasomotor symptoms during menopause, such as hot flashes and sweating.
• Used for its sedative properties, aiding in sleep and reducing anxiety.
• Used to prevent motion sickness and associated nausea, especially in long-distance travel.

To be taken as per doctor's prescription

In the case of an overdose of Pizotifen Syrup/Suspension, the severity of symptoms can vary. Initial signs may include drowsiness, restlessness, and dilated pupils. More severe effects can lead to seizures, respiratory depression, and even coma. Prompt medical intervention is necessary, as treatment may involve supportive care, gastric lavage, and close monitoring of vital signs. It is crucial to seek emergency medical assistance if an overdose is suspected.

In the case of a missed dose of Pizotifen Syrup/Suspension, it is generally recommended to take the missed dose as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses or have concerns about managing your medication, consult your healthcare provider for guidance on how to best maintain your treatment plan.

To use Pizotifen Syrup/Suspension, measure the prescribed dose using an oral syringe or a measuring cup, and administer it orally, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Following are the conditions or situations when Pizotifen Syrup/Suspension should not be used:

• Should not be given to children under 2 years of age.
• Contraindicated in individuals with a known allergy or hypersensitivity to Pizotifen or related compounds.
• Not recommended for patients with narrow-angle glaucoma or a history of glaucoma.
• Should not be used in patients with a history of gastrointestinal obstruction or ileus.
• Contraindicated during an acute attack of asthma.
• Not suitable for individuals with severe hepatic (liver) impairment.
• Should be avoided in patients with severe cardiovascular disease, including uncontrolled hypertension.
• Not recommended for patients with a history of seizures or epilepsy.
• Should be used with caution and under medical supervision in elderly patients due to increased risk of side effects.

The side effects of Pizotifen Syrup/Suspension may include:

• Weight gain
• Drowsiness or sedation
• Dry mouth
• Dizziness
• Fatigue and weakness
• Gastrointestinal disturbances (e.g., nausea, constipation)
• Skin rashes or itching

Following are the precautions and warnings for Pizotifen Syrup/Suspension:

• This medication should not be used in patients with a known allergy or hypersensitivity to Pizotifen or any of its excipients.
• Pizotifen may cause drowsiness and dizziness, so patients should avoid driving, operating heavy machinery, or engaging in activities requiring mental alertness until they know how the medication affects them.
• Caution is advised for patients with a history of epilepsy or convulsions, as Pizotifen may lower the seizure threshold.
• It should be used with caution in individuals with cardiovascular diseases, as it may affect blood pressure and heart rate.
• Elderly patients may be more sensitive to the side effects, particularly drowsiness and dizziness.
• Pizotifen should be used with caution in patients with a history of gastrointestinal disorders, as it can affect gastrointestinal motility.
• If symptoms persist or worsen, or if any severe side effects occur, consult a healthcare professional immediately.

Following are the drug interactions for Pizotifen Syrup/Suspension:

• Alcohol and other central nervous system (CNS) depressants can enhance the sedative effects of Pizotifen, potentially leading to increased drowsiness and impaired coordination.
• Pizotifen may interact with other medications that affect serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs) and monoamine oxidase inhibitors (MAOIs), increasing the risk of serotonin syndrome.
• Concomitant use with anticoagulants may increase the risk of bleeding. Close monitoring is necessary.
• The effectiveness of Pizotifen can be reduced by certain anti-epileptic drugs, requiring dosage adjustments.
• Antihistamines may potentiate the sedative effects of Pizotifen.
• Pizotifen may interfere with the metabolism of some medications, including certain antidepressants and antipsychotics, leading to increased drug levels in the body.
• Caution is advised when combining Pizotifen with medications that affect liver function, as it may alter Pizotifen's metabolism.

Following are the food interactions for Pizotifen Syrup/Suspension:

• Alcohol consumption should be minimized or avoided as it can enhance the sedative effects of Pizotifen, leading to increased drowsiness and impaired coordination.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of Pizotifen, potentially increasing its blood levels and the risk of side effects.
• Caffeine-rich beverages like coffee and energy drinks may counteract the sedative effects of Pizotifen, making it less effective for certain conditions.
• Fatty meals might slightly delay the absorption of Pizotifen, but this is generally not clinically significant.
• No specific food restrictions are necessary, but maintaining a balanced diet is advisable to support overall health.
• Always follow the dosing instructions provided by your healthcare professional to ensure optimal effectiveness and safety.
• If you have any concerns about food interactions, consult your pharmacist or healthcare provider for personalized advice.

Pizotifen Syrup/Suspension should be stored with caution, ensuring it remains in a cool and dry place, preferably at room temperature, shielded from direct sunlight and moisture. Maintain the medication in its original container, securely sealed to prevent contamination. Avoid storage in bathrooms or near heat-emitting appliances, as temperature fluctuations can compromise the drug's integrity. Regularly inspect the expiration date, and for disposal, refrain from flushing or draining. Instead, consult a pharmacist or healthcare professional for safe disposal practices. It is crucial to keep the medication inaccessible to children to prevent accidental ingestion.

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Following are the quick tips for Pizotifen Syrup/Suspension:

• Administer the syrup as directed by your doctor or pharmacist.
• Measure the dose accurately using the measuring cup or device provided.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Do not freeze the syrup as it may affect its consistency.
• Avoid taking it with other medications without consulting your healthcare provider.
• Regularly monitor for any allergic reactions, especially if you have a history of allergies.
• Contact your doctor if you experience any unusual symptoms or if your condition worsens.