Multigesic (0.1%) 10g Topical Cream

Diethylamine Salicylate Cream, which contains the active ingredient salicylate, works by penetrating the skin and exerting its therapeutic effects. Salicylates are known to possess analgesic, anti-inflammatory, and antipyretic properties. When applied topically, Diethylamine Salicylate is absorbed through the skin, where it inhibits the production of prostaglandins, which are key mediators of pain and inflammation. This inhibition occurs through the blocking of cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2, which are responsible for the synthesis of prostaglandins. By reducing prostaglandin production, Diethylamine Salicylate helps alleviate pain, decrease inflammation, and provide relief from discomfort associated with various musculoskeletal conditions. This mechanism of action makes it effective for localized pain management and inflammation reduction in the affected area.

Analgesic/Anti-inflammatory (Topical)

Cream

The following are the uses of Diethylamine Salicylate Cream:

• Used for treating pain and inflammation in muscles, joints, and tendons.
• Used for managing pain associated with sprains, strains, and sports injuries.
• Used for reducing pain and swelling in conditions like arthritis and tendonitis.
• Used for providing temporary relief from minor aches and pains.
• Used for its counterirritant effect, which helps distract the brain from deeper pain signals.
• Used for pre and post-operative care to alleviate discomfort.
• Used for soothing sore muscles and promoting recovery after intense physical activity.

In the case of an overdose of Diethylamine Salicylate Cream, it is important to recognize the signs and symptoms, which may include skin irritation, redness, and increased sensitivity. If ingested, symptoms could include nausea, stomach pain, and in severe cases, salicylate toxicity. Promptly seek medical advice and inform healthcare professionals about the product's ingredients to ensure appropriate treatment and management of potential adverse effects.

In the case of a missed dose of Diethylamine Salicylate Cream, it is generally recommended to apply the cream as soon as you remember. However, if it is almost time for your next scheduled application, skip the missed dose and continue with your regular dosing schedule. Do not apply extra cream to make up for the missed dose, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a medication tracking app to help you stay on track with your treatment plan.

To apply Diethylamine Salicylate Cream, clean and dry the affected area, then gently massage a thin layer of the cream onto the skin, repeating as needed, typically 3-4 times a day or as directed by your healthcare professional.

Here are the conditions and situations when Diethylamine Salicylate Cream should not be used:

• Do not use if you have an allergy or sensitivity to salicylates, aspirin, or any of the cream's components.
• Avoid using on broken or damaged skin, open wounds, or on skin with a severe rash.
• Not recommended for individuals with a history of asthma or other respiratory conditions triggered by salicylates.
• Should not be used on skin conditions caused by viruses such as cold sores or chickenpox.
• Avoid using around the eyes, mouth, or other mucous membranes.
• Do not use on skin that is already irritated or inflamed due to other skin conditions.
• Contraindicated for infants, young children, or individuals with a history of Reye's syndrome.
• Not suitable for individuals taking blood-thinning medications or with bleeding disorders.

The side effects of Diethylamine Salicylate Cream may include:

• Skin irritation or redness at the application site
• Burning or stinging sensation
• Itching or rash
• Swelling or inflammation
• Allergic reactions (hives, difficulty breathing, swelling of the face/lips/tongue)
• Increased sensitivity to sunlight (photosensitivity)
• Skin dryness or peeling
• In rare cases, severe skin reactions may occur.

Following are the precautions and warnings:

• Diethylamine Salicylate Cream should not be used on open wounds, severely damaged skin, or mucous membranes.
• Avoid contact with eyes and mouth. In case of accidental contact, rinse thoroughly with water.
• It is recommended to perform a skin patch test before using the cream to ensure you are not allergic to any of its components.
• Do not use this cream if you are allergic to aspirin or other salicylates.
• Discontinue use and consult a doctor if skin irritation, redness, or swelling occurs.
• Keep out of reach of children. If accidentally ingested, seek immediate medical attention.
• Consult a healthcare professional before using this cream if you are pregnant, breastfeeding, or have any underlying medical conditions.

Following are the drug interactions for Diethylamine Salicylate Cream:

• It may interact with other topical medications containing salicylates, potentially leading to increased absorption and enhanced side effects.
• Avoid using other NSAIDs (nonsteroidal anti-inflammatory drugs) simultaneously, as it can increase the risk of gastrointestinal bleeding and other adverse effects.
• Topical corticosteroids, when used with this cream, may increase the risk of skin atrophy and other skin-related side effects.
• Anticoagulants like warfarin could have their effect enhanced, potentially increasing the risk of bleeding.
• Diethylamine Salicylate Cream might decrease the efficacy of diuretics, requiring close monitoring.
• When used with medications that affect the skin barrier, such as exfoliants or astringents, increased skin irritation may occur.
• The use of other topical analgesics or counterirritants may lead to additive effects and increased skin sensitivity.

Following are the food interactions for Diethylamine Salicylate Cream:

• Avoid consuming aspirin-containing foods like pain-relieving candies or beverages while using this cream, as it may increase the risk of side effects.
• Limit your intake of foods high in salicylates, such as almonds, apples, apricots, berries, coffee, cucumbers, and grapes, as they can enhance the cream's effects.
• Avoid drinking excessive alcohol, as it may increase the skin's sensitivity and potentially cause irritation when using the cream.
• Grapefruit and grapefruit juice should be consumed in moderation, as they can affect the absorption of the cream's active ingredients.
• Spicy foods might cause skin flushing or irritation when using the cream, so consider reducing their intake.
• Avoid applying the cream right after a meal, especially if you've consumed hot or spicy foods, as it may increase skin sensitivity.
• Consult a healthcare professional if you have any specific dietary concerns or allergies to ensure a safe and effective treatment plan.

Diethylamine Salicylate Cream should be stored in a cool, controlled environment, preferably between 68°F and 77°F (20°C and 25°C). Keep the cream in its original container, tightly sealed, to maintain its integrity and prevent contamination. Avoid exposing the cream to direct sunlight, heat, or freezing temperatures, as these conditions can alter its effectiveness. Pay attention to the expiration date, and do not use the cream if it has expired. When disposing of any leftover or expired cream, do not flush it down the toilet or pour it into a drain. Instead, follow local guidelines or consult a healthcare professional for safe disposal methods. Keep the cream out of children's reach to prevent accidental contact or ingestion.

Following are the quick tips for Diethylamine Salicylate Cream:

• Clean and dry the affected area before applying the cream.
• Apply a thin layer of cream to the skin and gently rub it in.
• Wash your hands after application to avoid accidental contact with eyes or mouth.
• Avoid applying the cream to broken or irritated skin.
• Do not cover the treated area with bandages or tight clothing.
• Store the cream at room temperature, away from direct sunlight and moisture.
• Consult your doctor if you experience skin irritation or if symptoms persist.