MYFOL SYP 120ML

L-Methylfolate, the active form of folate, plays a crucial role in the metabolism of neurotransmitters and the synthesis of DNA and RNA. Its mechanism of action involves the direct participation in the one-carbon metabolism pathway. L-Methylfolate acts as a methyl donor, providing methyl groups necessary for various biochemical reactions in the body. Specifically, it supports the conversion of homocysteine to methionine, which is then further metabolized to produce S-adenosylmethionine (SAMe). SAMe is a critical methyl donor involved in the synthesis of neurotransmitters such as serotonin, norepinephrine, and dopamine. By increasing the availability of these neurotransmitters, L-Methylfolate can help regulate mood, cognitive function, and overall brain health. This mechanism is particularly relevant in conditions where folate deficiency or impaired metabolism may contribute to neurological and psychiatric disorders.

L-Methylfolate

Vitamin B derivative

Suspension

The following are the uses of L-Methylfolate Syrup/Suspension:

• Used for treating folate deficiency, especially in cases where absorption of regular folic acid is impaired.
• Used for managing depression, particularly in patients with low folate levels, as it can enhance the effectiveness of antidepressant medications.
• Used for supporting women's health during pregnancy, as it helps prevent neural tube defects in developing fetuses.
• Used for improving cognitive function and reducing the risk of cognitive decline in elderly individuals.
• Used for managing certain types of anemia, particularly megaloblastic anemia caused by folate deficiency.
• Used for supporting cardiovascular health by regulating homocysteine levels, which may reduce the risk of heart disease.
• Used for assisting in the treatment of certain neurological disorders, such as peripheral neuropathy, by promoting nerve health.
• Used for improving overall health and well-being, as folate is essential for numerous bodily functions, including DNA synthesis and repair.

In the case of an overdose of L-Methylfolate Syrup/Suspension, it is important to recognize the signs and act promptly. Symptoms may include nausea, dizziness, and gastrointestinal discomfort. Seek medical advice immediately, as prompt intervention is necessary. Do not induce vomiting unless instructed by a healthcare professional. The specific treatment for overdose will be determined by a medical expert based on the individual's condition.

In the case of a missed dose of L-Methylfolate Syrup/Suspension, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss several doses, consult your healthcare professional for advice, as they may recommend adjusting your dosage or provide guidance on how to catch up on missed doses safely.

To administer L-Methylfolate syrup/suspension, measure the prescribed dose using the provided dosing cup or oral syringe, ensuring an accurate measurement. Take the medication orally, preferably at the same time each day, with or without food, following the dosage instructions provided by your healthcare professional or as indicated on the medication's label.

Following are the conditions/situations when L-Methylfolate Syrup/Suspension should not be used:

• Not recommended for individuals with a known hypersensitivity or allergy to L-Methylfolate or any of its excipients.
• Should be avoided in patients with anaphylactic reactions or sensitivity to any folate products.
• Not suitable for individuals with untreated or uncontrolled epilepsy.
• Contraindicated in patients with untreated vitamin B12 deficiency.
• Should not be administered to patients with pernicious anemia, as it may mask the underlying condition.
• Not recommended for individuals with a history of bipolar disorder or manic episodes.
• Should be used with caution in patients with a history of cancer, especially those undergoing chemotherapy.

The side effects of L-Methylfolate Syrup/Suspension may include:

• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Loss of appetite
• Insomnia (difficulty sleeping)
• Dizziness
• Itching or skin rash
• Allergic reactions (rare)

Following are the precautions and warnings for L-Methylfolate Syrup/Suspension:

• This medication should not be used in patients with an allergy or hypersensitivity to L-methylfolate or any of its excipients.
• Patients with a history of seizures or epilepsy should use it with caution as it may lower the seizure threshold.
• It should be used with caution in individuals with a history of psychiatric disorders, as it may exacerbate symptoms.
• Patients with renal impairment may require dosage adjustments, and their kidney function should be monitored regularly.
• Not recommended for use during pregnancy unless the potential benefits outweigh the risks; consult a healthcare professional.
• It is unknown if L-methylfolate is excreted in breast milk, so caution is advised when using it while breastfeeding.
• This medication may cause dizziness or drowsiness; patients should avoid driving or operating heavy machinery until they know how it affects them.
• Always consult a healthcare provider or pharmacist for detailed information and personalized advice regarding the use of L-Methylfolate Syrup/Suspension.

Following are the drug interactions for L-Methylfolate Syrup/Suspension:

• May decrease the effectiveness of antiepileptic drugs like phenobarbital, phenytoin, and primidone, potentially requiring dosage adjustments.
• Can reduce the efficacy of methotrexate, a chemotherapy drug, by interfering with its transport across cell membranes.
• May interact with Levodopa, increasing its bioavailability and potentially leading to more pronounced side effects.
• L-Methylfolate can enhance the effects of antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), potentially increasing the risk of serotonin syndrome.
• It can increase the levels of S-adenosylmethionine (SAMe), which may lead to elevated mood and potential manic episodes in susceptible individuals.
• May reduce the efficacy of oral contraceptives, potentially impacting birth control effectiveness.
• Could potentially interact with anti-inflammatory drugs, such as ibuprofen, by altering their metabolism and increasing the risk of gastrointestinal side effects.

Following are the food interactions for L-Methylfolate Syrup/Suspension:

• Avoid consuming alcohol during treatment with L-Methylfolate as it may interfere with the absorption of the medication and potentially increase the risk of side effects.
• Folate-rich foods like leafy green vegetables, beans, citrus fruits, and fortified cereals can enhance the effects of L-Methylfolate, ensuring adequate folate levels in the body.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of L-Methylfolate, leading to potential fluctuations in its blood levels.
• High-fiber foods may delay the absorption of L-Methylfolate. Consider taking the medication on an empty stomach or following your healthcare provider's advice.
• Vitamin B12-rich foods such as meat, fish, and dairy products are beneficial, as L-Methylfolate works synergistically with vitamin B12 for optimal neurological health.
• Limit the intake of foods high in folic acid, as excessive consumption might mask a vitamin B12 deficiency.
• Avoid excessive caffeine intake, as it may interfere with the absorption of L-Methylfolate and potentially increase nervousness and anxiety.
• Consult your healthcare provider if you have a history of vitamin B12 deficiency or pernicious anemia, as L-Methylfolate may not be sufficient in these cases.

L-Methylfolate Syrup/Suspension should be stored in a controlled environment, specifically at room temperature, maintaining a cool and dry atmosphere, shielded from direct sunlight and moisture. Ensure the medication remains securely sealed within its original packaging to prevent contamination. Avoid storing it in the bathroom or near heat-emitting appliances, as temperature fluctuations can compromise its integrity. Regularly inspect the expiration date, and dispose of any unused or expired medication responsibly. Do not dispose of it via toilets or drains; instead, consult a pharmacist or healthcare professional for appropriate disposal guidelines. Additionally, exercise caution to keep the medication inaccessible to children to prevent accidental consumption.

Following are the quick tips for L-Methylfolate Syrup/Suspension:

• Consult a healthcare professional for dosage instructions specific to your condition.
• Administer the syrup as directed, ensuring accurate measurement.
• Store the syrup in a cool, dry place, away from direct sunlight.
• Ensure the syrup's expiration date is valid before use.
• Avoid sharing the medication with others, even if their symptoms resemble yours.
• Inform your doctor about all medications you're taking to prevent potential interactions.
• Contact your doctor if you experience any unusual symptoms or adverse reactions.