Mypheno Tab 30s

Mycophenolate Tablet, which contains mycophenolic acid as the active ingredient, primarily exerts its immunosuppressive effects by inhibiting inosine monophosphate dehydrogenase (IMPDH). IMPDH is a crucial enzyme involved in the de novo synthesis of guanosine nucleotides. By blocking IMPDH, mycophenolate selectively inhibits the proliferation of T and B lymphocytes, which are crucial components of the immune response. This inhibition occurs because lymphocytes are highly dependent on the de novo pathway for their nucleotide requirements, especially during their rapid proliferation in immune responses. As a result, mycophenolate suppresses the immune system by interfering with the ability of these cells to replicate and proliferate, making it effective in preventing organ rejection and managing autoimmune conditions.

Immunosuppressant

Tablet

The following are the uses of Mycophenolate Tablet:

• Used for preventing organ rejection in transplant patients, particularly kidney, heart, and liver transplants.
• Used for treating autoimmune diseases like lupus and rheumatoid arthritis by suppressing the immune system.
• Used for managing inflammatory bowel disease, reducing inflammation in the digestive tract.
• Used for treating severe skin conditions like psoriasis and pemphigus.
• Used for reducing symptoms and disease activity in multiple sclerosis.
• Used for controlling immune-related kidney disorders.
• Used for improving symptoms in certain types of vasculitis.

In the case of an overdose of Mycophenolate Tablets, it is important to act swiftly. Seek medical assistance immediately and provide the healthcare professional with details regarding the amount ingested. Symptoms of an overdose may include gastrointestinal issues, such as nausea, vomiting, or diarrhea, as well as potential changes in blood cell counts. Prompt action and medical evaluation are crucial to managing the situation effectively.

In the case of a missed dose of Mycophenolate Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, it is advisable to set reminders or use a pill organizer to help you stay on track with your medication routine. Always consult your healthcare provider if you have any concerns or questions regarding missed doses.

To take Mycophenolate tablets, swallow the prescribed number of tablets whole with a full glass of water, usually twice a day or as directed by your doctor, and ensure you follow the recommended dosage and schedule provided by your healthcare professional.

Following are the conditions/situations when Mycophenolate Tablet should not be used:

• Must not be taken by individuals with a known allergy to mycophenolate or any of its ingredients.
• Contraindicated in patients with severe kidney impairment or kidney failure.
• Should not be used in patients with severe active infections, especially those with low white blood cell counts.
• Not recommended for individuals with a history of gastrointestinal ulcers or gastrointestinal bleeding.
• Contraindicated during pregnancy as it may cause harm to the fetus.
• Should not be used by breastfeeding mothers as it can pass into breast milk and harm the baby.
• Avoid using Mycophenolate if you have a planned vaccination with a live vaccine.
• Not suitable for individuals with a history of severe liver disease or liver failure.
• Should be discontinued if a patient develops pure red cell aplasia (PRCA) or other severe blood disorders.

The side effects of Mycophenolate Tablet may include:

• Nausea and vomiting
• Diarrhea
• Stomach pain
• Increased risk of infections
• Fatigue and weakness
• High blood pressure
• Tremors or shaking

Following are the precautions and warnings for Mycophenolate Tablet:

• Mycophenolate is not recommended for individuals with known hypersensitivity or severe allergic reactions to mycophenolate or its derivatives.
• Regular monitoring of complete blood count is essential, and the drug should be used with caution in patients with pre-existing low white blood cell counts.
• Patients with a history of gastrointestinal disorders should exercise caution as the medication may exacerbate these conditions.
• Mycophenolate may increase the risk of infections, including opportunistic infections; immediate medical attention is required if any signs of infection appear.
• This medication may cause fetal harm; women of childbearing age should use effective contraception while on treatment and for 6 weeks after stopping the drug.
• Patients should be advised to avoid live vaccines during treatment and for a period after stopping Mycophenolate.
• Renal function should be monitored regularly, and dosage adjustments might be necessary in patients with kidney impairment.

Following are the drug interactions for Mycophenolate Tablet:

• Concomitant use with azathioprine, cyclophosphamide, or other immunosuppressants may increase immunosuppression and risk of infections.
• Live vaccines should be avoided as Mycophenolate can reduce vaccine efficacy.
• Probenecid can decrease the clearance of Mycophenolate, leading to increased drug levels.
• Mycophenolate can reduce the effectiveness of antacids, iron, and calcium supplements when taken together.
• The effect of anti-seizure medications like phenytoin and carbamazepine may be altered by Mycophenolate.
• Interactions with ACE inhibitors, such as lisinopril, can potentially increase the risk of renal impairment.
• Cholestyramine can decrease the absorption of Mycophenolate, reducing its effectiveness.

Following are the food interactions for Mycophenolate Tablet:

• Grapefruit and grapefruit juice should be avoided as they may decrease the effectiveness of Mycophenolate by altering its metabolism.
• Alcohol consumption should be minimized or avoided as it can increase the risk of gastrointestinal side effects and may impact the immune system.
• Live vaccines, such as those for measles, mumps, and rubella, should be avoided as Mycophenolate can reduce their effectiveness.
• High-fat meals can decrease the absorption of Mycophenolate, so it is recommended to take the medication on an empty stomach or with a low-fat meal.
• Dairy products like milk and yogurt may interfere with the absorption of Mycophenolate, so it is advisable to separate them by a few hours.
• Foods rich in potassium, like bananas and oranges, should be consumed in moderation as Mycophenolate can sometimes lead to increased potassium levels.
• Avoid black and green tea as they may reduce the absorption of Mycophenolate.
• Ensure adequate fluid intake to reduce the risk of gastrointestinal side effects.

Mycophenolate tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. It is crucial to keep the medication away from heat sources like heaters or radiators as temperature fluctuations can impact its effectiveness. Dispose of any unused or expired tablets responsibly; do not flush them or pour them down the drain. Consult your pharmacist or healthcare professional for appropriate disposal methods. Always exercise caution to keep medications away from children to prevent accidental ingestion.

Following are the quick tips for Mycophenolate Tablet:

• Take Mycophenolate Tablet exactly as prescribed by your doctor, do not change the dosage or stop without consulting them.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• It is best taken on an empty stomach, 1 hour before or 2 hours after a meal.
• Maintain a consistent schedule by taking the tablet at the same time each day.
• Avoid grapefruit and grapefruit juice during treatment as it may affect drug absorption.
• Inform your doctor about all medications and supplements you are taking to prevent potential interactions.
• Regular blood tests may be required to monitor your progress and adjust dosage if needed.