Myrin Forte (275/75/150mg) 80 Tablets

Rifampicin in the Rifampicin 150mg, Pyrazinamide 275mg Tablet primarily acts by inhibiting bacterial RNA polymerase. It binds to the beta-subunit of the enzyme, thereby blocking the RNA synthesis process. This interference with RNA synthesis leads to the inhibition of bacterial protein synthesis and subsequent bacterial cell death. Pyrazinamide, on the other hand, is a prodrug that is converted to its active form, pyrazinoic acid, inside the body. Pyrazinoic acid disrupts the cell membrane of susceptible bacteria, particularly Mycobacterium tuberculosis, by inhibiting the synthesis of essential fatty acids required for the mycobacterial cell wall. This disruption in cell membrane integrity contributes to the bactericidal effect of pyrazinamide.

Antitubercular

Tablet

The following are the uses of Rifampicin 150mg, Pyrazinamide 275mg Tablet:

• Used for treating active tuberculosis (TB), a severe bacterial infection.
• Used to eliminate latent TB bacteria in individuals who are at high risk of developing active TB.
• Used in combination with other anti-TB drugs to increase effectiveness and prevent resistance.
• Used to suppress the growth of Mycobacterium tuberculosis, the bacteria causing TB.
• Used to reduce the duration of TB treatment when combined with other medications.
• Used for treating TB infections in various parts of the body, including the lungs, bones, and joints.

In the case of an overdose of Rifampicin 150mg and Pyrazinamide 275mg tablets, symptoms may include nausea, vomiting, abdominal pain, and potential liver damage. Seek medical attention immediately if you suspect an overdose, as prompt treatment can help manage these effects. Ingesting excessive amounts of these medications can lead to severe gastrointestinal issues and may require hospitalization for supportive care and monitoring of liver function. Quick action is essential to ensure the best possible outcome.

In the case of a missed dose of Rifampicin 150mg, it is recommended to take the missed dose as soon as possible. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. For Pyrazinamide 275mg, if a dose is missed, take it as soon as you remember, but if it's close to the time for your next dose, skip the missed dose and continue with the regular dosing regimen. It is important to maintain a consistent medication schedule, but if you miss a dose, don't double the dose to make up for it.

To take the Rifampicin 150mg and Pyrazinamide 275mg Tablet, swallow the tablet whole with a full glass of water, preferably on an empty stomach, as directed by your healthcare professional, usually once daily or as instructed.

Here are the conditions and situations when Rifampicin 150mg and Pyrazinamide 275mg Tablet should not be taken:

• Avoid if you have a known allergy to Rifampicin, Pyrazinamide, or any other similar medications.
• Not suitable for individuals with severe liver or kidney disease.
• Should not be used by pregnant or breastfeeding women due to potential harm to the fetus or infant.
• Contraindicated in individuals with a history of severe porphyria.
• Avoid if you have a history of gout or blood disorders.
• Not recommended for individuals with a history of epilepsy or other seizure disorders.
• Should not be used if you have a history of alcohol abuse or liver damage due to alcohol.
• Avoid if you have a history of optic neuritis (inflammation of the optic nerve).
• Not suitable for individuals with a history of severe depression or other mental health disorders.
• Contraindicated in individuals with a history of severe gastrointestinal disorders or active stomach/intestinal bleeding.

The side effects of Rifampicin 150mg, Pyrazinamide 275mg Tablet may include:

• Nausea and vomiting
• Loss of appetite
• Dark-colored urine, tears, or sweat
• Fever or flu-like symptoms
• Skin rash or itching
• Yellowing of the skin or eyes (jaundice)
• Joint or muscle pain
• Abnormal liver function tests

Following are the precautions and warnings for Rifampicin 150mg, Pyrazinamide 275mg Tablet:

• This medication should be used with caution in patients with liver or kidney disease, as it may require dosage adjustments.
• Regular monitoring of liver function is necessary during treatment, and any signs of liver problems should be reported to the doctor immediately.
• Rifampicin can cause a reddish-orange discoloration of body fluids, which is usually harmless but may stain contact lenses.
• Patients should avoid driving or operating heavy machinery if they experience dizziness or visual disturbances.
• It may reduce the effectiveness of hormonal birth control methods, so alternative contraception should be considered.
• Inform your doctor about all medications you are taking, especially antiepileptic drugs, anticoagulants, and oral hypoglycemic agents, as Rifampicin can affect their metabolism.
• Patients with a history of gout or porphyria should exercise caution, as this medication may worsen these conditions.

Following are the drug interactions for Rifampicin 150mg and Pyrazinamide 275mg Tablet:

• Rifampicin induces the metabolism of various drugs, including antiretrovirals, oral contraceptives, and anticoagulants, potentially reducing their effectiveness.
• Pyrazinamide may increase the effects of anticoagulants like warfarin, requiring close monitoring of blood clotting times.
• Theophylline levels can be decreased by Rifampicin, reducing its therapeutic effect.
• Concomitant use with other hepatotoxic drugs (e.g., isoniazid, acetaminophen) may increase the risk of liver damage.
• Rifampicin can lower the efficacy of hormonal contraceptives, requiring alternative birth control methods.
• Anticonvulsant levels, such as phenytoin and carbamazepine, may be reduced by Rifampicin, necessitating dose adjustments.
• Pyrazinamide may interact with antidiabetic medications, affecting blood sugar control.

Following are the food interactions for Rifampicin 150mg and Pyrazinamide 275mg Tablet:

• Avoid consuming high-fat meals while taking this medication as it may affect the absorption and distribution of Rifampicin, leading to reduced effectiveness.
• Grapefruit and grapefruit juice should be avoided as they can increase the levels of Pyrazinamide in the blood, potentially causing liver-related side effects.
• Alcohol intake should be minimized or avoided as it may increase the risk of liver-related issues, especially when combined with Pyrazinamide.
• Avoid consuming dairy products like milk, cheese, or yogurt within 2 hours of taking the medication, as calcium can bind with Rifampicin, reducing its absorption.
• Foods high in tyramine (aged cheeses, cured meats, fermented foods) should be avoided as Rifampicin can interact, leading to potential blood pressure issues.
• Vitamin K-rich foods like leafy greens may reduce the effectiveness of the medication, so consider maintaining a consistent intake of these foods during treatment.
• Ensure a balanced diet, as Pyrazinamide can increase appetite, and weight gain is a potential side effect.
• Stay well-hydrated, especially when taking Pyrazinamide, to minimize the risk of liver-related complications.

Rifampicin 150mg and Pyrazinamide 275mg tablets should be stored in a dry and cool place, preferably at room temperature, away from direct exposure to sunlight and moisture. It is crucial to keep the tablets in their original packaging, tightly sealed, to maintain their integrity and prevent contamination. Do not store them in bathrooms or near heat-emitting appliances to avoid temperature fluctuations that can impact the medication's effectiveness. Dispose of any unused or expired tablets responsibly by consulting a pharmacist or healthcare professional for guidance on proper disposal methods. Keep the medication securely stored away from children to prevent accidental consumption.

Following are the quick tips for Rifampicin 150mg, Pyrazinamide 275mg Tablet:

• Take the tablet as directed by your doctor; do not crush or chew it.
• Ensure you complete the full course of medication as prescribed.
• Maintain a consistent time for taking the tablet each day.
• Avoid consuming alcohol as it may interfere with the medication's effectiveness.
• Stay hydrated by drinking plenty of fluids throughout the treatment.
• Inform your doctor about any other medications you are taking to prevent potential interactions.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.