Natural Factors WellBetX Complete Diabetic Multivitamin 120 Tablets

Berberine, a bioactive compound, exerts its effects through multiple mechanisms of action. One primary mechanism is its ability to activate the AMP-activated protein kinase (AMPK) pathway, which plays a crucial role in regulating cellular energy homeostasis. By activating AMPK, Berberine enhances insulin sensitivity, making it valuable in managing insulin resistance and type 2 diabetes. Additionally, Berberine inhibits the production of glucose in the liver, further contributing to blood sugar control. It also demonstrates antimicrobial properties by disrupting bacterial cell membranes and inhibiting DNA replication in microorganisms. Moreover, Berberine modulates the gut microbiota, promoting the growth of beneficial bacteria and reducing the population of harmful bacteria in the gut, which has implications for various gastrointestinal disorders. These diverse mechanisms contribute to Berberine's therapeutic potential in treating metabolic disorders, infections, and gastrointestinal conditions.

Berberine

Alkaloid isolate

Tablet

The following are the uses of Berberine Tablet:

• Used for treating diarrhea and improving gut health by reducing intestinal inflammation.
• Used for supporting heart health by improving cholesterol and triglyceride levels.
• Used for blood sugar control, especially in people with type 2 diabetes.
• Used for combating bacterial infections, including those affecting the skin and gastrointestinal system.
• Used for aiding in weight loss and reducing body fat percentage.
• Used for alleviating symptoms of depression and anxiety, potentially enhancing cognitive function.
• Used for its anti-inflammatory properties, which may benefit various inflammatory conditions.
• Used for boosting overall immune function and promoting a healthy immune response.

In the case of an overdose of Berberine Tablets, it is important to seek medical advice promptly. Common symptoms of an overdose may include nausea, vomiting, diarrhea, and abdominal pain. Severe cases could lead to more serious complications such as difficulty breathing, rapid heartbeat, or a significant drop in blood pressure. It is crucial to contact a healthcare professional or a poison control center for guidance on managing the overdose and for further instructions on necessary treatment.

In the case of a missed dose of Berberine Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare provider for guidance on how to safely resume your medication regimen. It is advisable to set reminders or use a pill organizer to help you stay on track with your medication routine and minimize missed doses.

To take Berberine tablets, start by swallowing one tablet with a full glass of water, preferably with a meal or as directed by your healthcare professional. It is recommended to take the tablet at the same time each day to maintain consistency and ensure optimal absorption.

Following are the conditions when Berberine Tablet should not be used:

• Avoid using if you have an allergy or sensitivity to Berberine or any related compounds.
• Do not take if you are pregnant or breastfeeding, as it may have adverse effects on the fetus and infant.
• Not suitable for children under 18 years of age without medical supervision.
• Contraindicated in individuals with chronic kidney disease or kidney failure.
• Should not be used if you have a gastrointestinal obstruction or severe gastrointestinal disorders.
• Avoid using if you have a known heart condition, such as heart failure or unstable angina.
• Do not take if you have low blood pressure (hypotension) or are taking medications to lower blood pressure.
• Not recommended for individuals with a history of liver disease or liver disorders.
• Discontinue use before surgery as it may interfere with blood sugar control during the procedure.

The side effects of Berberine Tablet may include:

• Diarrhea, constipation, and stomach pain are common side effects, especially at higher doses.
• Some individuals may experience skin rashes, itching, or redness.
• Berberine may cause lightheadedness or dizziness in some users.
• It can lower blood sugar levels, which might lead to symptoms like sweating, trembling, and confusion.
• Fatigue and drowsiness have been reported in some cases.
• There are rare cases of respiratory distress and difficulty breathing.
• May cause irregular heartbeat or palpitations in sensitive individuals.
• Berberine can interact with other medications, potentially leading to increased side effects.

Following are the precautions and warnings for Berberine Tablet:

• Berberine may cause liver damage in some individuals; it is important to monitor liver function during treatment, especially in those with pre-existing liver conditions.
• Patients with gastrointestinal issues such as constipation, ulcerative colitis, or gastrointestinal infections should exercise caution as Berberine may exacerbate these conditions.
• Not recommended for pregnant or breastfeeding women due to potential risks to the fetus and infant.
• Berberine may lower blood sugar levels, so patients with diabetes should closely monitor their blood sugar and consult a healthcare professional for dosage adjustments.
• Patients taking medications for diabetes, cholesterol, or immune-related conditions should inform their doctor, as Berberine may interact with these medications.
• Individuals with a history of heart disease or those taking medications for heart conditions should use Berberine under medical supervision.
• May cause skin photosensitivity, so it is advisable to limit sun exposure and use protective measures when outdoors during treatment.

Following are the drug interactions for Berberine Tablet:

• Berberine may interact with medications metabolized by the liver enzyme CYP3A4, such as cyclosporine, increasing the risk of side effects.
• It can decrease the effectiveness of oral contraceptives, so alternative birth control methods are recommended.
• May reduce the absorption of thyroid medications, requiring monitoring of thyroid function.
• Taking Berberine with hypoglycemic drugs may lead to a significant drop in blood sugar levels.
• Anticoagulants and antiplatelet drugs can have their effects enhanced by Berberine, increasing the risk of bleeding.
• Interactions with statins are possible, potentially leading to increased side effects like muscle pain or damage.
• The effectiveness of certain antibiotics, such as tetracyclines, may be reduced when taken with Berberine.

Following are the food interactions for Berberine Tablet:

• Grapefruit and grapefruit juice consumption should be avoided as they can increase Berberine levels in the blood, potentially leading to increased side effects.
• Alcohol intake should be minimized or avoided as it may interfere with the effectiveness of Berberine and potentially cause liver-related issues.
• Consuming high-fiber foods like whole grains, legumes, and vegetables can help improve the absorption of Berberine, promoting better gut health.
• Dairy products like milk and cheese may reduce the absorption of Berberine, so it is best to separate the timing of Berberine intake from dairy consumption.
• Avoid spicy and fried foods as they can potentially irritate the digestive system, reducing the effectiveness of Berberine in treating gastrointestinal issues.
• Garlic and onions, when consumed in large amounts, may interact with Berberine, affecting its metabolism and potentially increasing the risk of bleeding.
• Green tea and its extracts can enhance the effects of Berberine, but excessive consumption may lead to liver-related complications.
• Avoid high-sugar foods and beverages as they can counteract the positive effects of Berberine on blood sugar control.

Berberine Tablets should be stored in a cool, dry place, preferably at room temperature, ensuring protection from light and moisture. The original packaging should be tightly sealed to maintain the tablets' integrity and prevent contamination. Avoid exposing the tablets to heat, including sources like radiators or direct sunlight, as this can impact their effectiveness. Always adhere to the expiration date on the packaging, and when disposing of unused or expired tablets, refrain from flushing them or pouring them down the drain. Instead, consult a pharmacist or healthcare professional for appropriate disposal guidelines. Keep the medication safely locked away from children to prevent accidental consumption.

Following are the quick tips for Berberine Tablet:

• Consult your healthcare provider before starting this medication for personalized advice.
• Take the tablet as directed by your doctor, typically 1-2 tablets 2-3 times daily.
• Swallow the tablets whole with a full glass of water to aid in swallowing.
• Maintain consistency by taking your doses at regular intervals as prescribed.
• Berberine may cause temporary yellowing of the skin, which is harmless and reversible.
• Avoid taking antacids or stomach acid reducers simultaneously with Berberine.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.