Nabaxo (10mg) 10 Tablets

Rivaroxaban is an anticoagulant medication that works by directly inhibiting factor Xa, a key enzyme in the coagulation cascade. Its mechanism of action involves blocking the active site of factor Xa, thereby preventing the conversion of prothrombin to thrombin. This inhibition disrupts the intrinsic and extrinsic pathways of the coagulation cascade, ultimately inhibiting the formation of thrombin and the subsequent generation of fibrin, which are essential for blood clot formation. By specifically targeting factor Xa, rivaroxaban effectively prevents the development of deep vein thrombosis (DVT) and pulmonary embolism (PE) without the need for anticoagulant monitoring.

Oral anticoagulant.

Tablet

The following are the uses of Rivaroxaban 10mg Tablet:

• Used for preventing blood clots after hip or knee replacement surgery, reducing the risk of blood clots forming in the legs and lungs.
• Used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE), helping to prevent these clots from getting bigger and reducing the risk of new clots forming.
• Used for long-term treatment to prevent recurrent DVT and PE, especially in individuals with a history of these conditions.
• Used to reduce the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation, a type of irregular heartbeat.
• Used in patients with coronary artery disease and peripheral artery disease to lower the chances of cardiovascular events, such as heart attacks or strokes.
• Used for managing certain heart conditions, including acute coronary syndrome, to prevent blood clots and maintain blood flow.
• Used in specific cases of blood clots in the veins, helping to stabilize the condition and prevent complications.

In the case of an overdose of Rivaroxaban 10mg Tablets, it is important to recognize the potential risks and take appropriate action. Ingesting a higher dose than prescribed can lead to excessive bleeding, including gastrointestinal bleeding or bleeding in the brain. Prompt medical intervention is necessary to manage the situation effectively. The severity of symptoms may vary, but seeking medical advice is essential to ensure proper treatment and minimize the potential harm caused by an overdose.

In the case of a missed dose of Rivaroxaban 10mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this may increase the risk of bleeding. If you miss several doses, consult your healthcare provider for guidance on how to safely resume your medication and adjust your dosing schedule if necessary. It is recommended to set reminders or use a pill organizer to help you remember to take your medication as prescribed.

To take Rivaroxaban 10mg Tablet, swallow the tablet whole with a glass of water at the same time each day, preferably with your evening meal or as directed by your doctor, without crushing or chewing the tablet.

Here are the conditions and situations when Rivaroxaban 10mg Tablet should not be used:

• Do not use if you have active or uncontrolled bleeding.
• Contraindicated in patients with a history of severe allergic reactions to Rivaroxaban or any of its excipients.
• Should not be taken if you have a condition that increases your risk of bleeding, such as a stomach ulcer, bleeding in the brain, or recent brain, spinal, or eye surgery.
• Not recommended for individuals with severe kidney disease or end-stage renal disease.
• Avoid if you have antiphospholipid syndrome (APS) or heparin-induced thrombocytopenia (HIT).
• Do not use if you have a prosthetic heart valve.
• Should not be used in patients with severe liver disease or liver failure.
• Contraindicated in patients with a history of spinal or epidural anesthesia or spinal puncture, as this increases the risk of spinal hematoma.
• Not suitable for individuals with inherited bleeding disorders, such as hemophilia or von Willebrand disease.
• Avoid if you have recently had major surgery or plan to have surgery soon.

The side effects of Rivaroxaban 10mg Tablet may include:

• Increased risk of bleeding, including nosebleeds, bleeding gums, or prolonged bleeding from cuts.
• Easy bruising.
• Headache and dizziness.
• Nausea and vomiting.
• Stomach pain or indigestion.
• Skin rashes or itching.
• Fatigue and weakness.
• Joint pain and muscle cramps.

Following are the precautions and warnings for Rivaroxaban 10mg Tablet:

• Do not use if you have an active or recent bleeding disorder, such as peptic ulcers or bleeding in the brain.
• Patients with kidney or liver disease should exercise caution and consult a healthcare professional before use, as dosage adjustments may be necessary.
• Elderly patients may be more susceptible to bleeding risks, and regular monitoring is advised.
• Inform your doctor about all medications you are taking, especially anticoagulants, antiplatelet agents, or NSAIDs, to prevent potential drug interactions.
• Patients undergoing spinal or epidural procedures are at higher risk of developing hematomas, and close monitoring is required.
• Discontinuation of the medication should be gradual to prevent rebound thrombotic events.
• If you experience any signs of bleeding, such as unusual bruising, nosebleeds, or bleeding gums, seek medical attention promptly.
• This medication is not recommended for use during pregnancy or breastfeeding unless the potential benefits outweigh the risks.

Following are the drug interactions for Rivaroxaban 10mg Tablet:

• Concomitant use with other anticoagulants like warfarin, heparin, or antiplatelet drugs (e.g., aspirin, clopidogrel) can increase the risk of bleeding.
• Non-steroidal anti-inflammatory drugs (NSAIDs) may enhance the anticoagulant effect and further increase bleeding risk.
• Drugs that induce or inhibit CYP3A4 and P-gp, such as rifampicin, carbamazepine, or azole antifungals, may affect Rivaroxaban's metabolism and reduce its effectiveness.
• Rivaroxaban may increase the concentration of certain medications, including digoxin, statins, and some HIV protease inhibitors, requiring dose adjustments.
• Herbal supplements like St. John's Wort can reduce Rivaroxaban's plasma concentration, potentially decreasing its effectiveness.
• Caution is advised with P-gp inhibitors like cyclosporine or dronedarone, as they may increase Rivaroxaban levels in the body.
• Antacids containing aluminum or magnesium may reduce the absorption of Rivaroxaban, especially when taken simultaneously.

Following are the food interactions for Rivaroxaban 10mg Tablet:

• Avoid consuming high-fat meals while taking this medication as it can increase the absorption and peak concentration of Rivaroxaban.
• Grapefruit and grapefruit juice should be consumed with caution as they may increase the blood levels of Rivaroxaban, potentially raising the risk of bleeding.
• Alcohol intake should be limited as it can increase the risk of bleeding, especially when consumed in excess, due to its blood-thinning properties.
• Green leafy vegetables like spinach, kale, and broccoli, which are rich in vitamin K, should be consumed consistently to maintain a balanced diet. Sudden changes in vitamin K intake can affect the drug's effectiveness.
• Cranberry juice and cranberry products may increase the risk of bleeding when taken with Rivaroxaban, so monitor for any unusual bleeding or bruising.
• Herbal supplements like St. John's Wort should be used with caution as they can affect the metabolism of Rivaroxaban, potentially reducing its effectiveness.
• Always maintain a consistent diet and inform your healthcare provider about any significant dietary changes while taking Rivaroxaban.
• Certain foods like avocados, soybean products, and green tea may also interact with Rivaroxaban, so consult a healthcare professional for personalized advice.

Rivaroxaban 10mg Tablets should be stored in a secure and dry location, away from direct sunlight, moisture, and heat. It is crucial to keep the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. Always store it at room temperature, avoiding extreme temperatures. Remember to check the expiration date on the packaging regularly, and properly dispose of any unused or expired tablets. When disposing of the medication, do not flush it down the toilet or drain; instead, consult your pharmacist or healthcare professional for safe disposal methods. Ensure that the tablets are kept out of the reach of children to prevent accidental consumption. Responsible storage and disposal practices are essential for the safe management of Rivaroxaban 10mg Tablets.

Following are the quick tips for Rivaroxaban 10mg Tablet:

• Take the tablet as directed by your doctor, usually once daily with or without food.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• It is important to take the tablet at the same time each day for consistent blood levels.
• Do not stop taking the medication without consulting your doctor to prevent blood clots.
• Inform your doctor about all medications you are taking to avoid drug interactions.
• Regular blood tests may be required to monitor your response to the medication.
• Store the tablets in their original packaging at room temperature, away from moisture and heat.