Napreben (275mg) 32 Capsules

Naproxen Sodium, a nonsteroidal anti-inflammatory drug (NSAID), exerts its mechanism of action by inhibiting cyclooxygenase (COX) enzymes, primarily COX-1 and COX-2. These enzymes play a crucial role in the synthesis of prostaglandins, which are involved in mediating inflammation, pain, and fever. By blocking the action of COX enzymes, naproxen sodium reduces the production of prostaglandins, thereby alleviating pain, inflammation, and fever. Specifically, it prevents the conversion of arachidonic acid to prostaglandin H2, a precursor for various prostaglandins and thromboxanes. This action results in decreased inflammation, reduced swelling, and analgesic effects, making it effective in managing conditions such as arthritis, menstrual cramps, and acute pain.

NSAID (Non-steroidal anti-inflammatory drug)

Capsule

The following are the uses of Naproxen Sodium 275mg Capsule:

• Used for relieving acute pain, such as headaches, toothaches, and menstrual cramps.
• Used for reducing inflammation and managing symptoms of rheumatoid arthritis and osteoarthritis.
• Used for treating mild to moderate acute pain and fever.
• Used for alleviating discomfort from strains, sprains, and minor injuries.
• Used for reducing swelling and pain after surgical procedures.
• Used for managing pain and inflammation in conditions like gout and ankylosing spondylitis.
• Used for providing temporary relief from discomfort associated with backaches and muscle aches.

In the case of an overdose of Naproxen Sodium 275mg Capsules, individuals may experience symptoms such as severe stomach pain, nausea, vomiting, and gastrointestinal bleeding. Immediate medical intervention is necessary, and healthcare professionals should be contacted without delay. Prompt treatment can help manage the potential risks associated with an overdose, including addressing any gastrointestinal issues and providing appropriate care to mitigate further complications. It is crucial to act swiftly and seek professional medical advice.

In the case of a missed dose of Naproxen Sodium 275mg Capsule, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one unless advised by your healthcare professional. If you miss multiple doses, consult your doctor or pharmacist for guidance on how to safely resume your medication regimen.

To take Naproxen Sodium 275mg Capsule, simply swallow the capsule whole with a full glass of water, preferably with food or after a meal, as directed by your healthcare professional, and follow the dosage instructions provided for effective pain relief.

Following are the conditions or circumstances when Naproxen Sodium 275mg Capsule should not be taken:

• Allergy Do not take if you have a known allergy to Naproxen, other NSAIDs (Non-Steroidal Anti-Inflammatory Drugs), or any of the inactive ingredients in the capsule.
• Recent Heart Surgery Contraindicated in individuals who have recently undergone heart bypass surgery (CABG surgery).
• Active Stomach Ulcers Do not use if you have active, untreated, or frequent stomach ulcers or gastrointestinal bleeding.
• Severe Heart Failure Not suitable for patients with severe heart failure or heart disease.
• Advanced Renal (Kidney) Disease Should not be used in patients with advanced kidney disease or severe kidney problems.
• Aspirin-Sensitive Asthma Do not take if you have a history of asthma attacks or severe allergic reactions after taking aspirin or other NSAIDs.

The side effects of Naproxen Sodium 275mg Capsule may include:

• Stomach pain or upset
• Nausea and vomiting
• Heartburn or indigestion
• Dizziness or lightheadedness
• Headache
• Constipation or diarrhea
• Drowsiness or fatigue
• Skin rash or itching

Following are the precautions and warnings for Naproxen Sodium 275mg Capsule:

• Not recommended for individuals with a known allergy to Naproxen or other NSAIDs (Non-Steroidal Anti-Inflammatory Drugs).
• Patients with a history of gastrointestinal bleeding, ulcers, or other gastrointestinal disorders should use with caution and under medical supervision.
• May increase blood pressure, so patients with hypertension should be monitored regularly.
• Kidney function should be monitored during long-term use, especially in elderly patients and those with pre-existing kidney issues.
• Avoid excessive alcohol consumption while taking this medication as it may increase the risk of gastrointestinal bleeding.
• Not recommended for use during pregnancy, especially in the third trimester, unless advised by a healthcare professional.
• Consult a doctor before breastfeeding while using Naproxen Sodium.

Following are the drug interactions for Naproxen Sodium 275mg Capsule:

• Aspirin and other NSAIDs (e.g., ibuprofen, celecoxib) may increase the risk of gastrointestinal bleeding and ulcers when taken with Naproxen.
• Naproxen can decrease the effectiveness of antihypertensive medications, including ACE inhibitors, ARBs, and beta-blockers.
• Lithium levels may be increased when taken with Naproxen, requiring close monitoring.
• Diuretics, such as furosemide and hydrochlorothiazide, may have reduced diuretic and antihypertensive effects when used with Naproxen.
• Naproxen can increase the risk of bleeding when taken with anticoagulants like warfarin or antiplatelet drugs (e.g., clopidogrel).
• Corticosteroids and Naproxen may increase the risk of gastrointestinal side effects when combined.
• Methotrexate levels may be elevated, increasing the risk of toxicity, when used with Naproxen.

Following are the food interactions for Naproxen Sodium 275mg Capsule:

• Avoid excessive salt intake as it can increase blood pressure and reduce the effectiveness of the medication.
• Limit alcohol consumption as it can increase the risk of gastrointestinal bleeding and liver toxicity.
• Avoid grapefruit and grapefruit juice as they may interfere with the metabolism of the drug, increasing its levels in the body.
• Dairy products like milk and yogurt may decrease the absorption of Naproxen, consider separating doses from these foods.
• Avoid fatty or fried foods as they can increase stomach irritation and delay absorption.
• Spicy foods should be limited as they can aggravate the stomach lining and potentially worsen gastrointestinal side effects.
• Ensure adequate fluid intake to reduce the risk of kidney-related issues, especially when taking high doses for prolonged periods.
• Avoid caffeine-rich beverages as they may increase the risk of stomach irritation and interfere with the medication's absorption.

Naproxen Sodium 275mg Capsules should be stored in a secure and dry location, preferably at room temperature, ensuring it remains protected from light and moisture. It is crucial to keep the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. Avoid placing the capsules in bathrooms or near heat sources, as temperature fluctuations can impact their effectiveness. Always be mindful of the expiration date, and for safe disposal, refrain from flushing them down the toilet or pouring them into drains. Instead, consult a pharmacist or healthcare professional for appropriate disposal methods. Additionally, ensure the medication is stored out of children's reach to prevent accidental consumption.

Following are the quick tips for Naproxen Sodium 275mg Capsule:

• Consult a doctor or pharmacist before use if you have a history of stomach problems or allergies.
• Take the capsule with a full glass of water, preferably with or after food.
• Avoid alcohol consumption while taking this medication to reduce the risk of stomach irritation.
• Do not crush or chew the capsule; swallow it whole for optimal absorption.
• If you experience dizziness, avoid driving or operating heavy machinery.
• Inform your doctor about all the medications you are taking to prevent potential drug interactions.
• Store the capsules in a cool, dry place, away from direct sunlight and moisture.