Napreben (550mg) 32 Capsules

Naproxen Sodium, a nonsteroidal anti-inflammatory drug (NSAID), exerts its mechanism of action by inhibiting cyclooxygenase (COX) enzymes, primarily COX-1 and COX-2. These enzymes play a crucial role in the synthesis of prostaglandins, which are involved in mediating pain, inflammation, and fever. By blocking the action of COX enzymes, naproxen sodium reduces the production of prostaglandins, thereby alleviating pain and inflammation. Specifically, it suppresses the production of prostaglandin precursors, arachidonic acid, and other inflammatory mediators at the site of inflammation. This action results in the reduction of pain, swelling, and stiffness associated with various conditions, providing relief without directly affecting the route of administration or specific therapeutic applications.

NSAID (Nonsteroidal anti-inflammatory drug)

Capsule

The following are the uses of Naproxen Sodium 550mg Capsule:

• Used for relieving acute pain and reducing inflammation.
• Used for managing symptoms of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
• Used for treating acute gout attacks and relieving menstrual cramps.
• Used for reducing fever and alleviating headaches.
• Used for post-surgical pain management.
• Used for providing relief from toothaches and muscle strains.
• Used for short-term management of acute pain and discomfort.

In the case of an overdose of Naproxen Sodium 550mg Capsules, the severity of symptoms can vary. Common signs include stomach pain, nausea, vomiting, and dizziness. More severe cases may lead to rapid breathing, drowsiness, and potential kidney problems. It is important to seek medical advice promptly, as treatment may involve gastric decontamination and supportive care, ensuring the best possible outcome.

In the case of a missed dose of Naproxen Sodium 550mg Capsule, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss several doses, consult your healthcare professional for advice on how to safely resume your medication without affecting its efficacy.

To take Naproxen Sodium 550mg Capsule, swallow the capsule whole with a full glass of water, preferably with food or after a meal, as directed by your healthcare provider, and do not crush, chew, or break the capsule to ensure proper absorption and effectiveness.

Here are the situations or conditions when Naproxen Sodium 550mg Capsule should not be taken:

• Avoid if you have a known allergy or hypersensitivity to Naproxen, other NSAIDs, or any of the inactive ingredients in the medication.
• Do not use if you have a history of severe allergic reactions (anaphylaxis) to aspirin or other NSAIDs.
• Contraindicated in individuals with active or recent gastrointestinal bleeding or perforation.
• Should not be used in patients with advanced renal (kidney) disease or severe heart failure.
• Avoid if you have a history of asthma attacks or severe bronchospasm triggered by aspirin or other NSAIDs.
• Not recommended for individuals with a history of peptic ulcers or gastrointestinal bleeding.
• Do not take if you have recently undergone coronary artery bypass graft (CABG) surgery.
• Avoid using Naproxen Sodium if you have uncontrolled hypertension (high blood pressure).
• Should not be used in patients with severe liver impairment.
• Contraindicated during the third trimester of pregnancy due to potential fetal risks.

The side effects of Naproxen Sodium 550mg Capsule may include:

• Stomach pain or upset
• Nausea and vomiting
• Heartburn or indigestion
• Dizziness or lightheadedness
• Headache
• Diarrhea
• Gas or bloating
• Skin rash or itching

Following are the precautions and warnings for Naproxen Sodium 550mg Capsules:

• Do not exceed the recommended dosage, as it may increase the risk of gastrointestinal bleeding and cardiovascular events.
• Patients with a history of gastrointestinal bleeding, ulcers, or cardiovascular disease should use this medication with caution and under medical supervision.
• Avoid using this medication if you have a known allergy to Naproxen or other NSAIDs (Non-Steroidal Anti-Inflammatory Drugs).
• Naproxen may cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. Monitor for signs and symptoms.
• This medication can cause an increased risk of serious gastrointestinal adverse events, including bleeding, ulceration, and perforation of the stomach or intestines.
• Patients with kidney or liver impairment may require dosage adjustments and should be monitored closely.
• Elderly patients are at a higher risk of adverse reactions, especially gastrointestinal bleeding and kidney problems.
• Naproxen may cause dizziness or drowsiness; avoid driving or operating heavy machinery until you know how this medication affects you.

Following are the drug interactions for Naproxen Sodium 550mg Capsule:

• Concurrent use with other non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of gastrointestinal bleeding and kidney problems.
• Naproxen can reduce the effectiveness of angiotensin-converting enzyme (ACE) inhibitors and diuretics, leading to decreased blood pressure control.
• Lithium levels can be increased when used with Naproxen, potentially causing lithium toxicity.
• Anticoagulants like warfarin may have their effects enhanced, increasing the risk of bleeding.
• Naproxen may interfere with the cardioprotective effects of low-dose aspirin when taken together.
• Combining Naproxen with other drugs that increase the risk of bleeding, such as antiplatelet agents, may exacerbate this risk.
• Caution is advised when using Naproxen with angiotensin receptor blockers (ARBs) or beta-blockers, as it may further lower blood pressure.

Following are the food interactions for Naproxen Sodium 550mg Capsule:

• Avoid excessive salt or high-sodium foods, as Naproxen Sodium can increase sodium levels in the body.
• Alcohol consumption should be minimized or avoided as it can increase the risk of gastrointestinal bleeding and liver toxicity.
• Limit or avoid caffeine intake, as it can increase the risk of stomach irritation and interfere with the healing process.
• Avoid grapefruit and grapefruit juice as they can affect the metabolism of Naproxen, potentially increasing its levels in the body.
• Avoid fatty or greasy foods, as they may delay the absorption of Naproxen and reduce its effectiveness.
• Consume a balanced diet with fiber-rich foods to promote gastrointestinal health and reduce the risk of stomach-related side effects.
• Stay hydrated by drinking plenty of water, especially if you're at risk of dehydration or have kidney-related concerns.

Naproxen Sodium 550mg Capsules should be stored in a cool and dry place, preferably at room temperature, away from direct exposure to sunlight and moisture. Keep the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. It is crucial not to store it in the bathroom or near heat-emitting appliances to avoid temperature fluctuations that can impact its effectiveness. Proper disposal is essential; do not dispose of the medication by flushing or pouring it down the drain. Consult a pharmacist or healthcare professional for guidance on safe disposal methods. Always keep medicines out of children's reach to prevent accidental consumption.

Following are the quick tips for Naproxen Sodium 550mg Capsule:

• Consult a doctor for the right dosage based on your medical condition.
• Swallow the capsule whole with a full glass of water, don't crush or chew.
• Take with food or after meals to prevent stomach irritation.
• Avoid alcohol as it may increase the risk of stomach bleeding.
• Inform your doctor of any allergies or medical conditions before use.
• Do not take if you had allergic reactions to NSAIDs or aspirin.
• Store at room temperature, away from moisture and heat.
• Keep medication out of reach of children and pets.