Nassa (15mg) 20 Tablets

Mirtazapine, a tetracyclic antidepressant, exerts its mechanism of action primarily through modulation of neurotransmitters in the brain. It acts as an antagonist at specific serotonin receptors (5-HT2 and 5-HT3 receptors), leading to increased serotonin and norepinephrine levels in the synaptic cleft. This is achieved by blocking the inhibitory effect of serotonin on norepinephrine release. Mirtazapine also has a direct agonistic effect on certain alpha-2 adrenergic receptors in the brain, further contributing to its antidepressant effect by increasing norepinephrine and dopamine neurotransmission. By selectively targeting these receptors, mirtazapine enhances neurotransmitter activity, thereby alleviating depressive symptoms.

Antidepressant

Tablet

The following are the uses of Mirtazapine 15mg Tablet:

• Used for treating major depressive disorder in adults, offering symptom relief from depression and improving mood.
• Used to enhance appetite and promote weight gain in patients experiencing significant weight loss due to depression.
• Used to improve sleep patterns by reducing the time it takes to fall asleep and increasing overall sleep duration.
• Used for managing anxiety and restlessness associated with depression, providing a calming effect.
• Used to increase energy levels and motivation, combating the fatigue and lack of interest often linked with depression.
• Used to alleviate feelings of hopelessness and worthlessness, restoring a sense of well-being.
• Used as part of a comprehensive treatment plan for depression, potentially in combination with therapy or other medications.

To be taken as per doctor's prescription

In the case of an overdose of Mirtazapine 15mg Tablets, individuals may experience a range of symptoms including severe drowsiness, confusion, agitation, rapid heartbeat, and in some cases, seizures. It is important to recognize that an overdose can occur not only through intentional misuse but also by accidentally taking more than the prescribed dose. Prompt medical attention is necessary if an overdose is suspected, as healthcare professionals can provide appropriate treatment and support to manage the potential risks and complications associated with excessive Mirtazapine intake.

In the case of a missed dose of Mirtazapine 15mg Tablet, it is generally recommended to take the missed dose as soon as you remember, provided it is not too close to the time of your next scheduled dose. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or alarms to help you stay on track with your medication regimen.

To take Mirtazapine 15mg Tablets, swallow the tablet whole with a glass of water, preferably at bedtime, following the dosage instructions provided by your healthcare professional, typically starting with a lower dose and gradually increasing as directed.

Following are the conditions/situations when Mirtazapine 15mg Tablet should not be taken:

• Should not be taken if you are allergic to Mirtazapine or any of the other ingredients in the medication.
• Contraindicated in individuals with a history of severe kidney or liver disease.
• Not suitable for patients with a history of seizures or epilepsy.
• Should not be used if you have recently had a heart attack.
• Contraindicated during the acute recovery phase after a stroke.
• Avoid if you have severe respiratory conditions or difficulty breathing.
• Do not take this medication if you are currently taking Monoamine Oxidase Inhibitors (MAOIs) or have taken them in the last 14 days.
• Should not be used in individuals with severe blood disorders or bone marrow depression.

The side effects of Mirtazapine 15mg Tablet may include:

• Increased appetite and weight gain
• Drowsiness or sedation
• Dry mouth
• Dizziness
• Constipation
• Nausea and vomiting
• Blurred vision
• Restlessness or agitation

Following are the precautions and warnings for Mirtazapine 15mg Tablet:

• This medication can cause drowsiness and impaired judgment; avoid driving or operating machinery until you know how it affects you.
• Mirtazapine may cause a life-threatening condition called serotonin syndrome, especially when taken with other medications that increase serotonin levels. Seek immediate medical attention if you experience symptoms such as agitation, hallucinations, rapid heart rate, and coordination problems.
• Elderly patients may be more sensitive to the side effects, particularly dizziness and confusion. Regular monitoring is necessary.
• Patients with a history of seizures or conditions that increase seizure risk should use this medication with caution, as it may lower the seizure threshold.
• Mirtazapine can cause weight gain, so regular monitoring of weight and blood sugar levels is recommended, especially in diabetic patients.
• It may cause suicidal thoughts or actions in some individuals, particularly in the early stages of treatment or when the dosage is adjusted. Seek medical attention if you experience any unusual changes in mood or behavior.
• This medication should be used with caution in patients with liver or kidney disease, as dosage adjustments may be required. Regular monitoring of liver and kidney function is advised.

Following are the drug interactions for Mirtazapine 15mg Tablet:

• Mirtazapine can increase the effects of other sedative medications, including opioids, benzodiazepines, and certain antihistamines, leading to enhanced sedation and potential respiratory depression.
• Serotonin syndrome risk is increased when combined with other serotonergic agents like SSRIs, SNRIs, triptans, or tramadol. Close monitoring is essential.
• Blood pressure may drop significantly when used with antihypertensive medications, particularly those that affect norepinephrine reuptake.
• Mirtazapine can potentially reduce the effectiveness of levodopa in Parkinson's disease, and adjustments in dosage may be required.
• It may enhance the effects of anticoagulants, such as warfarin, necessitating closer monitoring of coagulation parameters.
• The metabolism of Mirtazapine can be affected by enzyme inducers like carbamazepine, potentially reducing its effectiveness.
• Caution is advised with medications that prolong the QT interval, as Mirtazapine may also prolong QT, increasing the risk of arrhythmias.

Following are the food interactions for Mirtazapine 15mg Tablet:

• Avoid consuming grapefruit and grapefruit juice as they can increase the concentration of Mirtazapine in the blood, leading to potential side effects.
• Alcohol consumption should be minimized or avoided as it can enhance the sedative effects of Mirtazapine, causing increased drowsiness and dizziness.
• Do not consume high-fat meals as they may reduce the absorption of Mirtazapine, affecting its effectiveness.
• Caffeine intake should be limited as it can interact with Mirtazapine, potentially causing restlessness and sleep disturbances.
• Foods rich in tyramine (aged cheeses, cured meats) should be avoided as they can interact with Mirtazapine, leading to increased blood pressure.
• Avoid herbal supplements like St. John's Wort, as they may reduce the effectiveness of Mirtazapine.
• Always follow your doctor's advice regarding dietary restrictions and medication adjustments.
• Maintain a balanced diet to support overall health while taking Mirtazapine.

Mirtazapine 15mg Tablets should be stored in a secure and dry location, away from direct exposure to sunlight, moisture, and heat. It is crucial to keep the tablets in their original packaging, ensuring the container is tightly sealed to maintain their integrity. Avoid placing the medication in humid areas like bathrooms, as moisture can compromise its quality. Always be mindful of the expiration date, and do not use the tablets beyond this date. When disposing of unused or expired Mirtazapine tablets, do not flush them or throw them into the trash. Instead, consult your pharmacist or local waste management guidelines for safe and environmentally responsible disposal methods. Keep the medication out of children's reach to prevent accidental consumption.

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Following are the quick tips for Mirtazapine 15mg Tablet:

• Take the tablet as directed by your doctor, typically once daily.
• Consume the tablet with a full glass of water, preferably at bedtime.
• Mirtazapine may cause drowsiness; avoid activities requiring alertness.
• Avoid alcohol as it can intensify the medication's sedative effects.
• Do not increase or decrease the dosage without medical advice.
• Store the tablets at room temperature, away from moisture and light.
• Inform your doctor about all medications you take to prevent potential interactions.