Natasan (5%) 5ml Eye Suspension

Natamycin Syrup/Suspension primarily acts by binding to ergosterol, a specific component present in the cell membrane of various fungi. This binding process creates channels in the fungal cell membrane, leading to increased membrane permeability. As a result, essential intracellular components leak out, disrupting the normal functioning and growth of the fungal cells. Natamycin specifically targets the fungal cell membrane without affecting human cell membranes due to the absence of ergosterol in human cells. This selective action makes it an effective antifungal agent, inhibiting the growth and proliferation of susceptible fungi.

Macrolide antifungal

Suspension

The following are the uses of Natamycin Syrup/Suspension:

• Used for treating oral thrush, a fungal infection in the mouth and throat.
• Used for preventing fungal growth and extending the shelf life of certain food products, especially in the dairy industry.
• Used for managing fungal infections in the gastrointestinal tract, ensuring effective treatment and symptom relief.
• Used for its antifungal properties, targeting a range of yeast and mold-related infections with precision.
• Used for oral fungal infections in immunocompromised patients, offering a targeted and effective treatment approach.
• Used for maintaining oral health by eliminating fungal pathogens and preventing their recurrence.
• Used for its ability to inhibit the growth of specific fungi, ensuring a healthy microbial balance in the body.
• Used for treating fungal infections in patients who are unresponsive to other antifungal medications, providing an alternative therapeutic option.

In the case of an overdose of Natamycin Syrup/Suspension, it is important to remain calm and seek medical advice promptly. Symptoms of an overdose may include nausea, vomiting, and gastrointestinal discomfort. Do not induce vomiting unless instructed by a healthcare professional. Medical treatment should focus on managing these symptoms and providing supportive care to ensure the patient's well-being.

In the case of a missed dose of Natamycin Syrup/Suspension, it is important to administer the medication as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. Consult your healthcare provider if you frequently miss doses or are unsure about how to adjust your medication schedule.

To administer Natamycin Syrup/Suspension, shake the bottle vigorously, measure the prescribed dose with an accurate measuring device like a syringe, and administer it orally, ensuring it is taken as directed by your healthcare professional, typically multiple times a day at regular intervals.

Here are the conditions or situations when Natamycin Syrup/Suspension should not be used:

• Avoid using if you have a known allergy or hypersensitivity to Natamycin or any other similar antifungal medication.
• Not suitable for individuals with swallowing difficulties or those who are unable to take oral medications.
• Contraindicated in patients with a history of liver or kidney disease, as Natamycin is primarily metabolized by these organs.
• Should not be used if you have a fungal infection that is not responsive to Natamycin or similar medications.
• Avoid using if you have a condition that weakens your immune system, as the effectiveness of Natamycin may be compromised.
• Not recommended for individuals with a history of gastrointestinal disorders that affect drug absorption.
• Do not use if you have a history of allergic reactions to other antifungal medications.
• Contraindicated in patients with a known sensitivity to any of the excipients or inactive ingredients in the Natamycin Syrup/Suspension.

The side effects of Natamycin Syrup/Suspension may include:

• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Skin rash or itching
• Allergic reactions (such as hives, swelling, or difficulty breathing)
• Taste changes (dysgeusia)
• Headache
• Dizziness

Following are the precautions and warnings for Natamycin Syrup/Suspension:

• Do not use if you are allergic to Natamycin or any other ingredients in the syrup.
• This medication should be used with caution in patients with liver or kidney disease, as it may require dosage adjustments.
• Natamycin can cause gastrointestinal side effects; monitor for any severe or persistent symptoms.
• Avoid driving or operating heavy machinery if the syrup causes dizziness or drowsiness.
• Do not consume alcohol while taking Natamycin as it may increase the risk of adverse effects.
• Natamycin should be used with caution in children, and the dosage should be determined by a healthcare professional.
• Inform your doctor about all medications you are currently taking to avoid potential drug interactions.

Following are the drug interactions for Natamycin Syrup/Suspension:

• Concurrent use with Amphotericin B or Colistimethate Sodium may lead to increased risk of kidney toxicity.
• Natamycin can interact with Cyclosporine, potentially increasing the risk of kidney dysfunction.
• The effectiveness of oral contraceptives may be reduced when taken with Natamycin.
• It may increase the blood levels of Digoxin, necessitating monitoring of Digoxin levels.
• Antifungal drugs like Fluconazole can enhance the concentration of Natamycin, requiring dosage adjustments.
• Natamycin can interact with H2-blockers such as Cimetidine, possibly leading to decreased absorption of Natamycin.
• When used with Tacrolimus, the risk of kidney toxicity may be elevated.

Following are the food interactions for Natamycin Syrup/Suspension:

• Natamycin can interact with dairy products, particularly milk and milk-based beverages. It may reduce the effectiveness of the medication.
• Avoid consuming grapefruit or grapefruit juice as it can alter the absorption and metabolism of Natamycin, potentially increasing its levels in the body.
• Alcohol consumption is not recommended with Natamycin as it may cause increased side effects like dizziness and stomach discomfort.
• Limit the intake of foods high in sugar content, as Natamycin is often used in the treatment of fungal infections and high sugar can promote fungal growth.
• Avoid spicy foods, as they can irritate the throat and may reduce the effectiveness of the medication.
• Dairy products like cheese and yogurt should be consumed with caution, as they might interfere with the absorption of Natamycin.
• Fermented foods like sauerkraut and kimchi may potentially interact with Natamycin due to their microbial content.
• It is advisable to maintain a balanced diet, ensuring adequate hydration, to support the overall effectiveness of Natamycin treatment.

Natamycin Syrup/Suspension should be stored in a controlled environment, preferably at room temperature between 68°F and 77°F (20°C and 25°C). Protect the medication from excessive heat, direct sunlight, and moisture by keeping it in a dry place. Always keep the syrup in its original container, tightly sealed, to maintain its integrity and prevent contamination. Ensure the medication is out of the reach of children and pets to avoid accidental consumption. When disposing of unused or expired Natamycin Syrup, do not pour it down the drain or flush it; instead, follow local guidelines for pharmaceutical waste disposal or consult a pharmacist for safe disposal practices. Regularly check the expiration date on the packaging to ensure the medication's effectiveness and safety.

Following are the quick tips for Natamycin Syrup/Suspension:

• Consult a doctor for prescription and dosage instructions.
• Administer the medication as directed, ensuring accurate measurement.
• Shake the bottle vigorously before each use to maintain consistency.
• Use the provided measuring device for precise dosage.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Check the expiration date regularly and discard outdated medication.
• Inform your doctor if you have any allergies or medical conditions before using this medication.
• Contact your healthcare provider if symptoms persist or worsen during treatment.