Navelbine (50mg/5ml) 1 Vial Injection

Navelbine (50mg/5ml) 1 Vial Injection

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  • Manufacturer ATCO LABORATORIES
  • Generic Name Vinorelbine

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Vinorelbine 50mg injection primarily acts as a mitotic inhibitor, disrupting microtubule formation during cell division. It binds to tubulin, preventing its assembly into microtubules, which are essential for chromosome segregation and spindle formation. This interference leads to cell cycle arrest at the metaphase stage, inhibiting cell proliferation and inducing apoptosis in rapidly dividing cancer cells. By destabilizing the mitotic spindle, vinorelbine disrupts the normal process of cell division, ultimately resulting in the inhibition of tumor growth.

  • Ingredients

    Vinorelbine
  • Drug Class

    Antineoplastic (anticancer) agent.

  • Dosage Form

    injection

  • Uses

    The following are the uses of Vinorelbine 50mg injection:

    • Used for treating non-small cell lung cancer (NSCLC), often as a first-line treatment option.
    • Used for managing advanced breast cancer, particularly in combination with other chemotherapy drugs.
    • Used to slow down the growth and spread of cancer cells by disrupting cell division.
    • Used as an alternative for patients who cannot tolerate more aggressive chemotherapy regimens.
    • Used in combination with other treatments, such as surgery or radiation therapy, for a comprehensive cancer treatment approach.
    • Used to improve survival rates and quality of life in cancer patients by controlling tumor progression.
    • Used under medical supervision, with dosage and treatment duration determined based on individual patient factors.
    • Used for symptom management and palliative care in advanced cancer cases.
  • In case of Overdose

    In the case of an overdose of Vinorelbine 50mg injection, it is crucial to seek medical assistance promptly. Overdose symptoms may include severe nausea, vomiting, diarrhea, and a significant drop in white blood cell count. Immediate treatment should focus on managing these symptoms and preventing further complications. Medical professionals may administer supportive care, closely monitor vital signs, and provide appropriate interventions to address the specific effects of the overdose.

  • Missed Dose

    In the case of a missed dose of Vinorelbine 50mg injection, it is important to consult your healthcare provider for specific instructions. Generally, if you realize you've missed a dose, contact your doctor or nurse promptly. They will advise you on whether to administer the missed dose or simply continue with the next scheduled dose. It is crucial not to double the dose to catch up, as this may increase the risk of side effects. Remember, the specific guidance for managing missed doses should always come from your healthcare team.

  • How To Use

    To administer Vinorelbine 50mg injection, reconstitute the powder with the provided diluent, gently swirl the vial to ensure complete dissolution, and then inject the solution intravenously as a slow infusion over 6-10 minutes, following the prescribed dosage schedule and under the supervision of a healthcare professional.

  • When Not to Use

    Here are the situations when Vinorelbine 50mg injection should not be used:

    • Must not be used in patients with a known allergy to Vinorelbine or any of its components, including other vinca alkaloids.
    • Not suitable for individuals with severe bone marrow suppression or low white blood cell counts.
    • Contraindicated in patients with severe liver disease or impaired liver function.
    • Should not be used during pregnancy as it may harm the fetus.
    • Avoid use in breastfeeding women as it can pass into breast milk.
    • Not recommended for patients with severe infections or weakened immune systems.
    • Do not administer to patients with known hypersensitivity to polyoxyethylated castor oil.
    • Not suitable for individuals with severe gastrointestinal disorders, including bowel obstruction.
    • Should be avoided in patients with severe kidney disease or impaired renal function.
    • Discontinue use if severe neurological disorders or peripheral neuropathy occurs.
  • Side Effects

    The side effects of Vinorelbine 50mg injection may include:

    • Nausea and vomiting
    • Constipation
    • Diarrhea
    • Fatigue and weakness
    • Loss of appetite
    • Hair loss (alopecia)
    • Low white blood cell count (neutropenia), which can increase the risk of infection
    • Numbness or tingling in hands and feet
  • Precautions & Warnings

    Following are the precautions and warnings for Vinorelbine 50mg Injection:

    • Do not use if you are allergic to Vinorelbine or any of its components.
    • This medication requires close medical supervision due to its potential for severe side effects; regular blood tests and monitoring are essential.
    • Vinorelbine can cause bone marrow suppression, leading to decreased white blood cells, red blood cells, and platelets. Regular blood tests are necessary to monitor this.
    • Patients with pre-existing bone marrow suppression or those receiving radiation therapy should use with caution and under medical supervision.
    • It may cause constipation, so patients are advised to maintain a high-fiber diet and drink plenty of fluids to prevent this side effect.
    • Vinorelbine can increase the risk of infection; patients should avoid contact with individuals who have infections or are sick.
    • Avoid pregnancy during treatment and for some time after; it may harm the fetus. Effective contraception is crucial while using this medication.
    • Breastfeeding women should consult their doctor as Vinorelbine may pass into breast milk.
  • Drug Interactions

    Following are the drug interactions for Vinorelbine 50mg injection:

    • Vinorelbine may interact with other chemotherapy agents, such as cisplatin, increasing the risk of bone marrow suppression and other toxicities.
    • It can enhance the effects of anticoagulants like warfarin, necessitating close monitoring of blood clotting parameters.
    • Concomitant use with certain antibiotics like erythromycin or ketoconazole may alter Vinorelbine metabolism, potentially leading to increased side effects.
    • Vinorelbine may interact with live vaccines, reducing their effectiveness and increasing the risk of infection.
    • Caution is advised when combining with anti-seizure medications, as it may affect their metabolism and require dosage adjustments.
    • Drugs that cause constipation, such as opioids, may increase the risk of gastrointestinal side effects when used with Vinorelbine.
    • The effectiveness of Vinorelbine may be reduced when taken with medications that induce certain liver enzymes, potentially requiring dosage modifications.
  • Food Interactions

    Following are the food interactions for Vinorelbine 50mg injection:

    • Avoid grapefruit and grapefruit juice as they may interfere with Vinorelbine's metabolism, leading to increased drug levels and potential toxicity.
    • Alcohol consumption should be limited or avoided as it can increase the risk of liver toxicity and may enhance the sedative effects of Vinorelbine.
    • Avoid high-fat meals before or after Vinorelbine administration, as it is primarily metabolized in the liver and high-fat foods can affect liver function.
    • Ensure adequate hydration by drinking plenty of fluids, especially water, to reduce the risk of dehydration and kidney-related side effects.
    • Avoid consuming black cohosh, St. John's Wort, and other herbal supplements without medical advice, as they may interact with Vinorelbine's metabolism.
    • Consult your healthcare provider about any dietary restrictions or modifications needed during Vinorelbine treatment, especially if you have pre-existing medical conditions.
    • Maintain a balanced diet rich in nutrients to support overall health and well-being during cancer treatment.
  • Storage/Disposal

    Vinorelbine 50mg injection should be stored in a controlled room temperature environment, typically between 20°C and 25°C (68°F to 77°F). Protect the injection vials from light and moisture by keeping them in their original packaging until use. Do not freeze the medication as it may affect its potency. Once the vial is opened, unused portions should be discarded as the sterility cannot be guaranteed. Dispose of all unused and expired medication responsibly; do not flush or pour into drains. Contact your healthcare provider or pharmacist for guidance on proper disposal methods, ensuring that the drug is not accessible to children or pets.

  • Quick Tips, if any

    Following are the quick tips for Vinorelbine 50mg Injection:

    • Vinorelbine injection is typically administered by a healthcare professional in a medical setting.
    • Ensure you inform your doctor about your medical history and current medications.
    • During treatment, stay well-hydrated and maintain good hygiene to support overall health.
    • Regularly monitor your blood cell counts and liver function as advised by your doctor.
    • Report any side effects like nausea, hair loss, or numbness to your healthcare provider promptly.
    • Avoid crowded places and people with infections to prevent getting sick during treatment.
    • Follow your doctor's instructions for the duration and frequency of the injections.

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