Negram (250mg/5ml) 60ml Suspension

Negram (250mg/5ml) 60ml Suspension

Sold Out 230 successful orders delivered in last 7 Days
  • Manufacturer SEARLE PHARMACEUTICALS (PVT.) LTD.
  • Generic Name Nalidixic Acid

Healthwire Pharmacy Ratings & Reviews (1500+)

4.9/ 5
Delivery by Today, 02:00 pm - 05:00 pm

Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • Dosage
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Control Drug
  • Quick Tips, if any
  • Description

    Nalidixic acid primarily targets bacterial DNA gyrase, a type II topoisomerase essential for DNA replication, transcription, and repair in bacteria. It acts as a competitive inhibitor, binding to the enzyme's active site and preventing it from catalyzing the breaking and rejoining of DNA strands. This binding interferes with the DNA gyrase's ability to introduce negative supercoils into DNA, which is crucial for DNA supercoiling and maintaining the structural integrity of bacterial DNA. By inhibiting DNA gyrase, nalidixic acid disrupts DNA replication and transcription, leading to bacterial cell death. This mechanism is selective for bacterial cells because DNA gyrase is not present in mammalian cells, making it an effective antibiotic against susceptible bacteria.

  • Ingredients

    Nalidixic Acid
  • Drug Class

    Quinolone antibiotic

  • Dosage Form

    Suspension

  • Uses

    The following are the uses of Nalidixic Acid Syrup/Suspension:

    • Used for treating urinary tract infections caused by susceptible bacteria.
    • Used for its ability to inhibit the growth of certain types of bacteria, specifically targeting their DNA replication process.
    • Used for effectively relieving symptoms like pain, burning sensation, and frequent urination associated with UTIs.
    • Used for its broad-spectrum activity against various Gram-negative bacteria, including E. coli and Proteus species.
    • Used for short-term treatment, typically 5-10 days, to minimize the risk of bacterial resistance.
    • Used for its effectiveness in treating acute uncomplicated cystitis in adults and children over 3 months old.
    • Used for reducing the likelihood of infection recurrence when used as directed.
    • Used for its good absorption and concentration in the urine, ensuring targeted treatment.
  • Dosage

    To be taken as per doctor's prescription

  • In case of Overdose

    In the case of an overdose of Nalidixic Acid Syrup/Suspension, immediate medical attention is necessary. Symptoms may include nausea, vomiting, dizziness, and in severe cases, seizures or respiratory distress. Prompt action should be taken, such as contacting a healthcare professional or a poison control center, who can provide specific guidance based on the patient's condition and the amount ingested. Quick response and appropriate medical care are crucial to managing and minimizing the risks associated with overdosing.

  • Missed Dose

    In the case of a missed dose of Nalidixic Acid Syrup/Suspension, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may advise you to restart the medication or provide alternative instructions. It is crucial to maintain a consistent dosing routine for this medication to ensure its effectiveness.

  • How To Use

    To administer Nalidixic Acid Syrup/Suspension, shake the bottle well, measure the prescribed dose with a dosing spoon or oral syringe, and take it orally, following the recommended dosage instructions provided by your healthcare professional, typically taken every 6 hours, with or without food, ensuring not to exceed the prescribed amount.

  • When Not to Use

    Here are the conditions or situations when Nalidixic Acid Syrup/Suspension should not be used:

    • Avoid using in individuals with a known allergy or hypersensitivity to Nalidixic Acid or other quinolone antibiotics.
    • Contraindicated in patients with a history of seizures or conditions that lower the seizure threshold.
    • Should not be used in patients with severe kidney impairment or kidney failure.
    • Not recommended for children under 3 months of age due to potential joint and cartilage damage.
    • Avoid using in pregnant women, especially during the first trimester, as it may cause harm to the developing fetus.
    • Contraindicated in breastfeeding mothers, as it can pass into breast milk and harm the nursing infant.
    • Should not be used in patients with a history of tendon disorders or those at increased risk of tendon problems.
    • Not suitable for patients with myasthenia gravis, as it may exacerbate muscle weakness.
  • Side Effects

    The side effects of Nalidixic Acid Syrup/Suspension may include:

    • Nausea and vomiting
    • Diarrhea
    • Loss of appetite
    • Headache
    • Dizziness
    • Skin rashes or itching
    • Sensitivity to sunlight
  • Precautions & Warnings

    Following are the precautions and warnings for Nalidixic Acid Syrup/Suspension:

    • This medication should not be used in patients with a known hypersensitivity or allergy to Nalidixic Acid or other related quinolone antibiotics.
    • Not recommended for children under 18 years of age as it may cause damage to growing bones and joints.
    • Patients with a history of kidney or liver disease should use this medication with caution, as it is primarily eliminated through these organs.
    • Avoid exposure to sunlight or UV rays, as Nalidixic Acid can increase the sensitivity of the skin to sunlight and cause severe sunburn.
    • Patients may experience dizziness or drowsiness; they should avoid driving or operating heavy machinery until they know how the medication affects them.
    • Alcohol consumption should be avoided while taking this medication as it may increase the risk of certain side effects.
    • Nalidixic Acid should be used with caution in elderly patients, as they may be more susceptible to its side effects.
    • Pregnant and breastfeeding women should consult their doctor before taking this medication, as it may have potential risks to the fetus or infant.
  • Drug Interactions

    Following are the drug interactions for Nalidixic Acid Syrup/Suspension:

    • May decrease the effectiveness of live bacterial vaccines, so they should not be given concurrently.
    • Nalidixic acid can reduce the plasma levels of antacids containing magnesium, aluminum, or calcium.
    • Probenecid may decrease the renal tubular secretion of nalidixic acid, potentially increasing its concentration in the body.
    • Concomitant use with theophylline may increase the risk of seizures.
    • May enhance the effects of oral anticoagulants, requiring careful monitoring of prothrombin time.
    • Nalidixic acid can increase the plasma concentrations of cyclosporine, a potent immunosuppressant.
    • Concurrent use with other antibiotics, such as rifampin, may result in decreased efficacy of both drugs.
  • Food Interactions

    Following are the food interactions for Nalidixic Acid Syrup/Suspension:

    • Avoid consuming dairy products like milk, cheese, or yogurt within 2 hours before or after taking Nalidixic Acid, as calcium can decrease its absorption.
    • Grapefruit and grapefruit juice should be consumed with caution as they may increase the levels of the drug in the blood, potentially leading to increased side effects.
    • Alcohol intake is not recommended as it can increase the risk of side effects, particularly central nervous system (CNS) reactions like dizziness and lightheadedness.
    • Avoid high-fat meals as they may delay the absorption of Nalidixic Acid, affecting its effectiveness.
    • Do not consume iron supplements or multivitamins with minerals at the same time as Nalidixic Acid, as iron can interfere with its absorption.
    • Vitamin K-rich foods like leafy greens may interact with Nalidixic Acid, affecting its anticoagulant properties. Consult your doctor for dietary advice.
    • Ensure adequate fluid intake to prevent dehydration while taking this medication.
    • Always follow the dosage instructions provided by your healthcare professional for the best results.
  • Storage/Disposal

    Nalidixic Acid Syrup/Suspension requires careful storage and disposal to ensure safety and environmental responsibility. Store it at room temperature, away from sunlight and moisture, preferably in its original container with a tight-fitting lid to maintain its integrity. Avoid extreme temperatures by keeping it away from heat sources like ovens or radiators. Always check the expiration date, and if the medication is expired or no longer needed, do not flush it or pour it down the drain. Contact your pharmacist or healthcare provider for instructions on proper disposal methods. Keep the syrup securely stored, out of children's reach, to prevent accidental consumption. Responsible storage and disposal practices are crucial for the well-being of both individuals and the environment.

  • Control Drug

    No

  • Quick Tips, if any

    Following are the quick tips for Nalidixic Acid Syrup/Suspension:

    • Consult a doctor for the correct dosage and duration; do not self-medicate.
    • Ensure the prescribed dose is measured accurately using a measuring cup or syringe.
    • Administer the syrup/suspension orally, and do not mix with other medications without medical advice.
    • Store the medication at room temperature, away from excessive heat and moisture.
    • Do not freeze the syrup/suspension.
    • Check the expiration date before using, and discard if expired.
    • Contact a healthcare professional if you experience any severe or persistent side effects.
    • Inform your doctor about any other medications or supplements you are taking to avoid potential interactions.

Customers also bought

Get Upto 10% discount on all items.

signup image

Healthwire Pharmacy provides 100% genuine medicines straight to your doorstep.

Order Now! & Avail

Upto 10% OFF On All Your Pharmacy Orders!

Need Help
Need Help?

If you face any issue, feel free to contact us. We provide 24/7 support to assist your problems

What Our Customers have to Say

Maham hassan

From Lahore

September 29, 2024

Thankyou guys for delivering on my doorstep

Muhammad Salman

From Lahore

September 25, 2024

Healthwire Pharmacy offers excellent service and convenience. I am impressed!

Mehreen

From Sialkot

September 25, 2024

I have ordered from here before. Good experience.

Maleeka

From Karachi

September 30, 2024

I recently started using Healthwire and have already become a loyal customer. They offer a wide range of products at great prices, and the delivery is always on time. Their customer service is excellent, highly recommended!

Sundas

From Lahore

September 25, 2024

I was a bit doubtful about using an online pharmacy, but Healthwire exceeded my expectations. The prices were very reasonable, and the delivery was quick and smooth. I would definitely use it again.

Jahangir Khan

From Lahore

October 03, 2024

After a great experience with my first order, I had no hesitation in placing another one. Thanks, Healthwire Pharmacy!

Sara Khan

From Islamabad

September 25, 2024

Every medicine which I am unable to find outside is available here and very fast delivery also. Highly satisfied.

Syed Naveed Abbas bukhari

From Lahore

September 25, 2024

I recently started using Healthwire, and I am already a fan. They have a vast selection of products at affordable prices, which is a huge relief for my wallet. Their delivery is always prompt, and their customer service is top-notch. Thank you.

Ayaan

From Faisalabad

September 28, 2024

Healthwire always has the medicines that I struggle to find elsewhere, and their delivery is incredibly fast. I am highly satisfied with their service.

Shazi baig

From Multan

September 29, 2024

I had a great experience that's why I have placed my order again. Thanks Healthwire pharmacy.

Mr.Saad Feroz

From Lahore

October 05, 2024

If you’re looking for a reliable healthcare app, Healthwire is the best choice. It covers everything for my family’s medical needs, with fantastic offers and smooth customer service. The app makes things so easy, it’s a 5-star experience!