NELIZAMET 2/500 TAB

The mechanism of action of Metformin 500mg and Rosiglitazone is primarily focused on improving insulin sensitivity and glucose metabolism. Metformin works by inhibiting glucose production in the liver, reducing the amount of glucose absorbed from food in the intestines, and increasing the body's sensitivity to insulin. It primarily targets the liver, where it suppresses gluconeogenesis, leading to decreased hepatic glucose output. Additionally, metformin enhances insulin-stimulated peripheral glucose uptake, particularly in skeletal muscle. On the other hand, Rosiglitazone, a thiazolidinedione, acts as a potent agonist for the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) found in adipose tissue, skeletal muscle, and the liver. Activation of PPAR-gamma regulates the transcription of insulin-responsive genes involved in glucose and lipid metabolism. This action enhances insulin sensitivity by facilitating glucose uptake and utilization in peripheral tissues, particularly in skeletal muscle and adipose tissue. The combined effect of these two drugs leads to better blood sugar control by improving the body's response to insulin and reducing overall glucose production and absorption.

Biguanide and Thiazolidinedione.

Tablet

The following are the uses of Metfomin 500mg, Rosiglitazone Tablet:

• Used for treating type 2 diabetes, helping control blood sugar levels.
• Used to improve insulin sensitivity and reduce insulin resistance.
• Used to enhance the body's response to its naturally produced insulin.
• Used to lower blood glucose by reducing glucose production in the liver.
• Used for managing weight and promoting weight loss in some cases.
• Used to reduce the risk of diabetic complications such as heart disease and stroke.
• Used to improve overall blood circulation and cardiovascular health.
• Used to support long-term blood sugar management and diabetes control.

In the case of an overdose of Metformin 500mg or Rosiglitazone Tablets, it is important to recognize the potential severity of the situation. Symptoms may include lactic acidosis, hypoglycemia, or gastrointestinal issues. Seek medical advice promptly, as treatment may involve gastric lavage, supportive care, and monitoring of vital signs. Quick action can help mitigate the risks associated with these medications when taken in excess.

In the case of a missed dose of Metformin 500mg, it is generally recommended to take the missed dose as soon as you remember, unless it is close to the time for your next scheduled dose. In this case, skip the missed dose and continue with your regular dosing schedule. For Rosiglitazone tablets, if you miss a dose, take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose and continue with your regular dosing regimen. It is important to try to take your medications at the same time each day to maintain consistent blood sugar control.

To take Metformin 500mg and Rosiglitazone tablets, swallow one tablet of each medication as a single dose, preferably with the first meal of the day or as directed by your healthcare provider, without crushing or chewing them.

Following are the conditions or situations when Metformin 500mg and Rosiglitazone Tablet should not be taken:

• Should not be used in patients with a known allergy to Metformin, Rosiglitazone, or any other ingredients in the formulation.
• Contraindicated in patients with diabetic ketoacidosis.
• Not suitable for individuals with severe kidney disease or kidney failure.
• Should not be used if the patient has a history of liver disease or increased liver enzymes.
• Contraindicated in patients with a history of heart failure or heart problems.
• Not recommended for individuals with a recent history of heart attack or stroke.
• Should not be taken if the patient is undergoing a radiologic exam with an injectable contrast dye.
• Not suitable for individuals with a history of metabolic acidosis, including diabetic ketoacidosis.
• Should be avoided during pregnancy and breastfeeding.
• Not recommended for children below 10 years of age.

The side effects of Metformin 500mg and Rosiglitazone Tablet may include:

• Nausea and vomiting
• Stomach pain or discomfort
• Diarrhea
• Metallic taste in the mouth
• Dizziness or lightheadedness
• Increased thirst and frequent urination
• Weight gain
• Swelling of the hands or feet

Following are the precautions and warnings for Metformin 500mg, Rosiglitazone Tablet:

• This medication should not be initiated in patients with severe renal impairment or kidney disease, and it should be temporarily discontinued prior to any radiologic procedure involving the use of iodinated contrast materials.
• Lactic acidosis, a rare but serious metabolic complication, is a risk associated with the use of Metformin. Discontinue use if lactic acidosis is suspected.
• Patients with liver disease should not use this medication, as it can increase the risk of liver-related side effects.
• Regular monitoring of liver function is recommended during therapy.
• Inform your doctor if you have a history of heart disease, as this medication can impact cardiovascular health.
• Rosiglitazone may cause fluid retention, which can lead to or exacerbate heart failure. Monitor for signs and symptoms of heart failure.
• This medication may cause ovulatory dysfunction and has the potential for unintended pregnancy in premenopausal women. Consider using contraceptives during treatment.
• Elderly patients may be more susceptible to the hypoglycemic effects of this medication; monitor blood glucose levels closely.

Following are the drug interactions for Metformin 500mg and Rosiglitazone Tablet:

• Furosemide and other diuretics may reduce the effectiveness of Metformin, requiring dosage adjustments.
• Rosiglitazone may interact with gemfibrozil, increasing the risk of adverse effects. Close monitoring is necessary.
• Insulin or other anti-diabetic medications can have additive effects with both Metformin and Rosiglitazone, potentially causing hypoglycemia.
• Beta-blockers, like metoprolol, can mask the symptoms of hypoglycemia caused by Metformin and Rosiglitazone.
• Certain corticosteroids may increase blood glucose levels, reducing the effectiveness of Metformin and Rosiglitazone.
• Drugs that affect kidney function, such as ACE inhibitors (e.g., lisinopril), may impact Metformin elimination.
• Caution is advised when using Metformin with contrast media, as it may increase the risk of contrast-induced nephropathy.

Following are the food interactions for Metformin 500mg and Rosiglitazone Tablet:

• Avoid excessive alcohol consumption while taking these medications as it can increase the risk of lactic acidosis, a serious side effect associated with Metformin.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Rosiglitazone, leading to increased blood levels and potential side effects.
• Fatty foods can impact the absorption of Rosiglitazone, so it is advisable to take the medication on an empty stomach or with a low-fat meal.
• Avoid high-fat meals as they can increase the absorption of Rosiglitazone, potentially leading to higher blood levels and increased side effects.
• Limit caffeine intake as it may interact with Metformin, affecting its effectiveness and potentially causing jitteriness or increased heart rate.
• Avoid natural licorice as it can reduce the effectiveness of Metformin by interfering with its absorption.
• Be cautious with vitamin B12 supplements as Metformin can decrease its absorption, potentially leading to vitamin B12 deficiency over time.
• Follow a healthy diet as directed by your healthcare provider, as both medications are often used in the management of diabetes and require consistent dietary management.

Metformin 500mg and Rosiglitazone tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. It is crucial not to store them in the bathroom or near heat-emitting appliances, as temperature fluctuations can impact their effectiveness. Always adhere to the expiry date on the packaging, and when disposing of unused or expired tablets, refrain from flushing them down the toilet or pouring them down the drain. Instead, consult your pharmacist or healthcare professional for appropriate disposal practices. Keep all medications securely stored, out of the reach of children, to prevent accidental consumption.

Following are the quick tips for Metformin 500mg and Rosiglitazone Tablets:

• Always take the medication as directed by your doctor; do not adjust the dosage without medical advice.
• Swallow the tablets whole with a full glass of water; do not crush, chew, or break them.
• Take Metformin with meals to reduce stomach upset and facilitate absorption.
• Rosiglitazone may be taken with or without food, but be consistent with your routine.
• Maintain a consistent daily schedule for taking your medication.
• Regularly monitor your blood sugar levels as advised by your healthcare provider.
• Store both medications at room temperature, away from moisture and heat.