NEO PHENICOL HC OINT 3G

Chloramphenicol, a component of the ointment, primarily acts as a broad-spectrum bacteriostatic antibiotic. It inhibits bacterial protein synthesis by binding reversibly to the 50S subunit of the bacterial ribosome, thereby interfering with the peptide transferase activity and subsequent protein synthesis. This mechanism effectively halts the growth and multiplication of susceptible bacteria. Hydrocortisone, the other active ingredient, is a potent corticosteroid that reduces inflammation by suppressing the release of inflammatory mediators and inhibiting the immune system's response. It achieves this by inhibiting the production of arachidonic acid derivatives, such as prostaglandins and leukotrienes, and by reducing the expression of inflammatory genes.

Chloramphenicol, Hydrocortisone [ 0.5 %w/w]

Antibiotic, Glucocorticoid

Ointment

The following are the uses of Chloramphenicol, Hydrocortisone [ 0.5 %w/w] Ointment:

• Used for treating superficial bacterial infections of the external eye and its adnexa
• Used to reduce inflammation and itching associated with various eye conditions
• Used for bacterial conjunctivitis, blepharitis, and post-operative eye inflammation
• Used to treat allergic reactions and swelling around the eye
• Used for corneal ulcers and abrasions
• Used to manage inflammatory conditions like keratitis and iritis
• Used as a post-operative medication after eye surgeries
• Used to prevent infection and promote healing in minor eye injuries

In the case of an overdose of Chloramphenicol, prompt medical attention is required. Symptoms may include bone marrow suppression, leading to decreased blood cell production. For Hydrocortisone [0.5% w/w] Ointment, excessive use can result in skin irritation, thinning, or local side effects. Seek medical advice if either medication is ingested or applied in larger quantities than prescribed, especially in children, as prompt intervention can mitigate potential health risks.

In the case of a missed dose of Chloramphenicol, apply the ointment as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra ointment to make up for the missed dose. For Hydrocortisone [0.5 %w/w] Ointment, if you forget to apply it, apply it as soon as you remember, but avoid applying too much to compensate for the missed application. It is important to maintain a consistent treatment routine for both medications.

To apply Chloramphenicol, Hydrocortisone [0.5 %w/w] Ointment, gently clean and dry the affected area, then apply a thin layer of the ointment directly to the skin, typically two to three times a day or as directed by your healthcare provider, ensuring you follow the prescribed frequency and duration of use.

Following are the conditions or situations when Chloramphenicol, Hydrocortisone [0.5 %w/w] Ointment should not be used:

• Do not use if you have a known allergy or sensitivity to chloramphenicol or hydrocortisone.
• Avoid using on patients with viral, fungal, or tubercular lesions of the eye.
• Not suitable for individuals with bacterial infections that are not responsive to chloramphenicol.
• Do not apply if the patient has a history of hypersensitivity or allergic reactions to any of the ointment's components.
• Contraindicated for patients with a history of corneal ulcers or perforations.
• Should not be used in individuals with untreated ocular herpes simplex.
• Avoid using if the patient has a history of ocular surgery, especially with corneal involvement.
• Not recommended for long-term use due to the risk of potential side effects.
• Do not use if the patient is already using other eye medications without consulting a healthcare professional.

The side effects of Chloramphenicol, Hydrocortisone [0.5 %w/w] Ointment may include:

• Skin irritation or burning at the application site
• Itching or rash
• Thinning of the skin
• Allergic reactions (such as hives, swelling, or difficulty breathing)
• Increased acne or skin infections
• Slow wound healing
• Changes in skin pigmentation (lightening or darkening)
• Prolonged use may lead to adrenal gland suppression

Following are the precautions and warnings for Chloramphenicol, Hydrocortisone [0.5 %w/w] Ointment:

• Do not use this ointment if you are allergic to any of its ingredients, including chloramphenicol or hydrocortisone.
• Avoid applying the ointment to large areas of broken or damaged skin, as it may increase the risk of side effects.
• Do not use the ointment for prolonged periods without medical supervision, especially on the face or in children.
• If your condition does not improve or worsens after a few days of using the ointment, consult a healthcare professional.
• Avoid contact with eyes, and if accidental contact occurs, rinse thoroughly with water.
• Wash your hands thoroughly after applying the ointment to avoid accidental transfer to sensitive areas.
• Keep out of reach of children and pets. Store at room temperature, away from direct sunlight.

Following are the drug interactions for Chloramphenicol, Hydrocortisone [0.5 %w/w] Ointment:

• Chloramphenicol may interact with other antibiotics like macrolides and aminoglycosides, potentially increasing the risk of side effects and altering therapeutic effects.
• Use with caution when combining with anticoagulants, as it may increase bleeding risk.
• Avoid using with other corticosteroids, as it may lead to increased corticosteroid effects and potential adrenal suppression.
• The ointment may reduce the efficacy of live vaccines, so consult a healthcare professional before vaccination.
• Concomitant use with other immunosuppressants can enhance immunosuppression and increase infection risk.
• Monitor blood sugar levels when used with antidiabetic medications, as it may alter glucose control.
• Chloramphenicol can inhibit the metabolism of certain medications, including some anticonvulsants, potentially increasing their levels in the body.

Following are the food interactions for Chloramphenicol, Hydrocortisone [0.5 %w/w] Ointment:

• Avoid consuming grapefruit and grapefruit juice, as they may interfere with the medication's metabolism and increase Chloramphenicol levels in the body, potentially leading to adverse effects.
• Alcohol consumption should be limited as it can increase the risk of gastrointestinal bleeding when combined with Chloramphenicol.
• Avoid high-fat meals as they may decrease the absorption of Hydrocortisone, reducing its effectiveness.
• Dairy products like milk and yogurt may decrease the absorption of Chloramphenicol, so consider separating these foods from medication intake.
• Avoid spicy foods as they can irritate the skin and exacerbate skin conditions, reducing the effectiveness of the ointment.
• Consuming foods rich in vitamin K, such as leafy greens, can help maintain healthy blood clotting, which may be affected by Chloramphenicol.
• Ensure adequate fluid intake to prevent dehydration, which can affect the skin's health and response to the ointment.
• Limit caffeine intake as it may interact with Hydrocortisone, potentially affecting its effectiveness.

Chloramphenicol, Hydrocortisone [0.5 %w/w] Ointment should be stored in a cool and dry place, preferably at room temperature, ensuring it is protected from light and moisture. Keep the ointment in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. Avoid exposing the medication to extreme temperatures by storing it away from heat sources or direct sunlight. Dispose of any unused or expired ointment responsibly; do not discard it into wastewater or the environment. Consult your pharmacist or healthcare provider for guidance on appropriate disposal methods in your area, and keep all medications out of the reach of children to prevent accidental exposure.

Following are the quick tips for Chloramphenicol and Hydrocortisone [0.5 %w/w] Ointment:

• Apply a thin layer to the affected area as directed by your doctor.
• Wash your hands before and after application to maintain hygiene.
• Gently clean and dry the affected area before applying the ointment.
• Avoid applying to broken or irritated skin, and follow the prescribed dosage.
• Do not cover the treated area with a bandage unless instructed by your doctor.
• Store the ointment at room temperature, away from direct sunlight and moisture.
• Inform your doctor if your condition doesn't improve or worsens during treatment.