Neocom-S (10/10mg) 7 Tablets

Ezetimibe and Simvastatin work synergistically to reduce cholesterol levels. Ezetimibe selectively inhibits the absorption of cholesterol in the small intestine by targeting the Niemann-Pick C1-Like 1 (NPC1L1) protein, which is responsible for cholesterol uptake. By blocking NPC1L1, ezetimibe reduces the amount of cholesterol absorbed from food and the circulation. Simvastatin, on the other hand, belongs to the statin class of drugs and acts by competitively inhibiting HMG-CoA reductase, a key enzyme in the liver responsible for cholesterol production. This inhibition leads to a decrease in hepatic cholesterol levels, stimulating LDL receptors and increasing LDL uptake, ultimately reducing circulating LDL-C levels. The combination of these two mechanisms provides a dual approach to lowering cholesterol, making it more effective than either drug alone.

Ezetimibe 10mg, Simvastatin 10mg

Statin/Cholesterol Absorption Inhibitor.

Tablet

The following are the uses of Ezetimibe 10mg, Simvastatin 10mg Tablet:

• Used for lowering high cholesterol and triglyceride levels in the blood.
• Used for preventing the absorption of cholesterol from the intestine.
• Used for reducing the production of cholesterol in the liver.
• Used for treating high cholesterol and improving overall heart health.
• Used for managing cholesterol levels in patients with a genetic predisposition to high cholesterol.
• Used for helping to reduce the risk of heart disease and stroke.
• Used for supporting a healthy cardiovascular system alongside lifestyle changes.

In the case of an overdose of Ezetimibe 10mg and Simvastatin 10mg tablets, the severity of symptoms can vary. Common effects may include muscle pain, tenderness, and increased liver enzyme levels. In more serious cases, rhabdomyolysis, characterized by severe muscle pain, weakness, and dark urine, can occur. Prompt medical intervention is necessary, as doctors may recommend discontinuing the medication and providing supportive care to manage symptoms and prevent further complications.

In the case of a missed dose of Ezetimibe 10mg, it is recommended to take the missed dose as soon as you remember, but if it's almost time for your next scheduled dose, skip the missed one. For Simvastatin 10mg Tablet, if you miss a dose, take it as soon as you remember, but if it's near the time for your next dose, skip the missed dose and continue with your regular dosing schedule. It is generally advised not to double the dose to make up for a missed one. Consult your healthcare provider if you have any concerns or if you miss multiple doses.

To take Ezetimibe 10mg and Simvastatin 10mg tablets, swallow one tablet daily, preferably in the evening, with or without food, as directed by your healthcare professional, ensuring you follow the prescribed dosage and do not crush or chew the tablets.

Following are the conditions or situations when Ezetimibe 10mg, Simvastatin 10mg Tablet should not be taken:

• Do not take if you are allergic to Ezetimibe, Simvastatin, or any other similar cholesterol-lowering medications.
• Avoid if you have active liver disease or unexplained elevated liver enzymes.
• Should not be used if you are pregnant or breastfeeding.
• Not suitable for individuals with homozygous familial hypercholesterolemia.
• Contraindicated in patients with severe renal impairment or end-stage renal disease.
• Do not take if you have a history of muscle pain, tenderness, or weakness, especially if caused by a previous statin medication.
• Avoid if you have a history of myopathy or rhabdomyolysis.
• Should not be used if you regularly consume large amounts of alcohol.

The side effects of Ezetimibe 10mg, Simvastatin 10mg Tablet may include:

• Muscle pain and weakness
• Stomach pain or cramps
• Nausea and vomiting
• Constipation or diarrhea
• Increased liver enzymes
• Headache
• Fatigue and dizziness
• Skin rash or itching

Following are the precautions and warnings for Ezetimibe 10mg, Simvastatin 10mg Tablet:

• Do not start or continue this medication if you have active liver disease or unexplained elevated liver enzymes, as it may cause further liver damage.
• Regular liver function tests are necessary while on this medication to monitor for any potential liver-related issues.
• Patients with a history of muscle pain or weakness should be closely monitored, as this medication can increase the risk of muscle-related side effects.
• Alcohol consumption should be avoided or limited as it may increase the risk of liver-related problems and can interact with the medication.
• Inform your doctor if you have diabetes, as this medication may affect blood sugar levels.
• This medication may cause birth defects and should not be taken during pregnancy or while breastfeeding without medical advice.
• It is important to disclose your complete medical history, including any allergies, to your healthcare provider before starting this medication.

Following are the drug interactions for Ezetimibe 10mg, Simvastatin 10mg Tablet:

• Use with strong CYP3A4 inhibitors like itraconazole, ketoconazole, HIV protease inhibitors, or erythromycin can significantly increase Simvastatin levels, leading to increased risk of rhabdomyolysis.
• Grapefruit juice should be avoided as it may increase Simvastatin levels, potentially leading to myopathy.
• When combined with other HMG-CoA reductase inhibitors or fibrates, there is an increased risk of myopathy/rhabdomyolysis, especially with gemfibrozil and fenofibrate.
• The use of Ezetimibe with cyclosporine may increase the risk of myopathy/rhabdomyolysis.
• When taken with coumarin anticoagulants, Simvastatin may potentiate the anticoagulant effect, requiring monitoring and dose adjustment.
• Caution is advised with Amiodarone or Verapamil, as they may increase the risk of myopathy/rhabdomyolysis when used with Simvastatin.
• Concomitant use with other lipid-lowering medications like niacin or bile acid sequestrants may increase the risk of adverse effects.

Following are the food interactions for Ezetimibe 10mg, Simvastatin 10mg Tablet:

• Grapefruit and grapefruit juice should be avoided as they may interfere with the metabolism of Simvastatin, potentially increasing its levels in the blood and the risk of muscle-related side effects.
• Limit alcohol consumption as it can increase the risk of liver problems, especially when combined with Simvastatin.
• Avoid high-fat meals as they can increase the absorption of Ezetimibe, which may lead to higher levels in the blood and potential side effects.
• Avoid or limit the consumption of foods high in cholesterol and saturated fats, as these medications are used to manage cholesterol levels.
• Do not consume large amounts of cranberry juice as it may interact with Ezetimibe, affecting its absorption.
• Consume a balanced diet low in saturated fats and cholesterol to support the effectiveness of the medication.
• Follow a healthy dietary plan as recommended by your healthcare provider for optimal results.
• Stay hydrated by drinking plenty of water, especially when taking these medications.

Ezetimibe 10mg, Simvastatin 10mg tablets should be stored in a cool and dry place, preferably at room temperature, away from excessive heat, direct sunlight, and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to air and humidity. Do not store the medication in the bathroom or kitchen, as these areas may have high humidity. It is crucial to dispose of any unused or expired tablets properly, avoiding flushing or pouring them down the drain. Contact your pharmacist or local waste management authority for guidance on safe disposal methods to protect the environment. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Ezetimibe 10mg and Simvastatin 10mg Tablet:

• Consult your doctor or pharmacist for personalized advice on taking these medications.
• Take the tablets as directed by your healthcare provider, ensuring you follow the prescribed dosage.
• Swallow the tablets whole with a full glass of water; do not crush or chew them.
• Maintain a consistent schedule by taking your medication at the same time each day.
• Inform your doctor about all medications/supplements you're taking to prevent interactions.
• Do not stop taking the medication without consulting your doctor to avoid complications.
• Store the tablets at room temperature, away from moisture and light.