NEOCOM ST 10/40MG

Ezetimibe and Simvastatin work synergistically to lower cholesterol levels. Ezetimibe acts by inhibiting the absorption of cholesterol in the small intestine, primarily targeting the Niemann-Pick C1-like 1 (NPC1L1) protein, which is responsible for cholesterol uptake. This inhibition reduces the amount of cholesterol entering the bloodstream. Simvastatin, on the other hand, belongs to the statin class of drugs and functions by competitively inhibiting HMG-CoA reductase, a key enzyme in the liver responsible for cholesterol production. By blocking this enzyme, Simvastatin decreases the liver's ability to produce cholesterol, leading to a reduction in circulating low-density lipoprotein (LDL) cholesterol levels. Together, these mechanisms contribute to the effective management of high cholesterol.

Ezetimibe 10mg, Simvastatin 40mg

Statin and cholesterol absorption inhibitor.

Tablet

The following are the uses of Ezetimibe 10mg, Simvastatin 40mg Tablet:

• Used for lowering high cholesterol and triglyceride levels in the blood.
• Used to prevent cholesterol absorption in the intestines, reducing overall cholesterol levels.
• Used to block the production of cholesterol in the liver, helping to control LDL cholesterol.
• Used to reduce the risk of heart disease and stroke in individuals with high cholesterol.
• Used for managing cholesterol levels in patients who have not responded adequately to diet and lifestyle changes alone.
• Used to slow down the progression of atherosclerosis and improve cardiovascular health.
• Used as a long-term treatment option to maintain healthy cholesterol levels.

In the case of an overdose of Ezetimibe 10mg and Simvastatin 40mg tablets, individuals may experience varying symptoms. Common effects include muscle pain, tenderness, and weakness, which can lead to rhabdomyolysis, a severe muscle condition. Other potential signs include liver damage, gastrointestinal issues, and, in rare cases, kidney failure. It is crucial to seek medical advice promptly if an overdose is suspected, as early intervention can help manage these adverse effects effectively.

In the case of a missed dose of Ezetimibe 10mg and Simvastatin 40mg Tablet, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to adjust your medication regimen. It is important to maintain consistency in taking these medications as prescribed to ensure their effectiveness in managing cholesterol levels.

To take the Ezetimibe 10mg, Simvastatin 40mg Tablet, swallow the tablet whole with a full glass of water once daily, preferably in the evening, as directed by your healthcare provider.

Following are the conditions or situations when Ezetimibe 10mg, Simvastatin 40mg Tablet should not be taken:

• Avoid if you are allergic to Ezetimibe or Simvastatin or any other similar medications.
• Do not take this medication if you have active liver disease or unexplained elevated liver enzymes.
• Contraindicated in individuals with a history of serious adverse reactions to statins (e.g., myopathy, rhabdomyolysis).
• Should not be used if you are pregnant or breastfeeding.
• Avoid if you have uncontrolled seizures or a history of them.
• Not suitable for individuals with homozygous familial hypercholesterolemia.
• Do not consume large amounts of alcohol while taking this medication.
• Should not be used if you have had recent major surgery or trauma.

The side effects of Ezetimibe 10mg, Simvastatin 40mg Tablet may include:

• Muscle pain or weakness
• Stomach pain or cramps
• Nausea and vomiting
• Constipation or diarrhea
• Increased liver enzymes
• Headache
• Dizziness
• Skin rash or itching

Following are the precautions and warnings for Ezetimibe 10mg, Simvastatin 40mg Tablet:

• This medication should be used with caution in patients with liver disease as it may increase the risk of liver enzyme abnormalities.
• Regular liver function tests are recommended during treatment, and if abnormalities occur, the medication should be discontinued.
• Patients with a history of muscle pain or weakness should inform their doctor, as this medication can rarely cause muscle problems.
• It is important to disclose any other medications being taken to avoid potential drug interactions.
• Patients should avoid consuming large quantities of grapefruit or grapefruit juice as it may increase the levels of the drug in the body.
• Not recommended for individuals with a known allergy to Ezetimibe or Simvastatin or any other statin medications.
• Diabetic patients should monitor their blood sugar levels regularly as this medication may affect glucose control.

Following are the drug interactions for Ezetimibe 10mg, Simvastatin 40mg Tablet:

• Concomitant use with other lipid-lowering agents like fibrates (e.g., gemfibrozil) or niacin may increase the risk of myopathy and rhabdomyolysis.
• Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) can significantly increase simvastatin levels, leading to increased risk of myopathy/rhabdomyolysis.
• Grapefruit juice should be avoided as it can increase simvastatin levels, potentially increasing the risk of adverse effects.
• The combination with amiodarone or verapamil may increase the risk of myopathy/rhabdomyolysis, and dose adjustments are necessary.
• Ezetimibe may slightly increase blood levels of cyclosporine, so monitoring of cyclosporine levels is recommended.
• Rifampin, a CYP3A4 inducer, may decrease the effectiveness of simvastatin, and alternative lipid-lowering therapy may be required.
• Phenytoin, phenobarbital, and other CYP2C9 inducers may decrease the effectiveness of simvastatin.
• Interactions with oral anticoagulants (e.g., warfarin) may occur, requiring monitoring of INR and potential dose adjustments.

Following are the food interactions for Ezetimibe 10mg, Simvastatin 40mg Tablet:

• Avoid consuming large amounts of grapefruit or grapefruit juice as it may increase the levels of Simvastatin in the blood, leading to potential muscle-related side effects.
• Limit alcohol consumption as it can increase the risk of liver-related issues, especially when combined with Simvastatin.
• Avoid high-fat meals as they can increase the absorption of Ezetimibe, potentially leading to increased side effects.
• Grapefruit juice can decrease the effectiveness of Ezetimibe, so it's best to separate it from medication intake.
• Dairy products, particularly those high in fat, might interfere with Ezetimibe absorption.
• Certain types of cheese and high-fat dairy can interact with Simvastatin, increasing the risk of muscle-related side effects.
• Consuming a balanced diet low in saturated and trans fats is recommended to support the medication's effectiveness.
• Consider limiting or avoiding foods fortified with sterols or stanols, as they may reduce Ezetimibe's absorption.

Ezetimibe 10mg, Simvastatin 40mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to environmental factors. It is crucial not to store the medication in bathrooms or near heat-emitting appliances, as temperature fluctuations can impact its effectiveness. Dispose of any unused or expired tablets responsibly; avoid flushing them down the toilet or pouring them into drainage systems. Consult your pharmacist or healthcare professional for guidance on appropriate disposal methods, and ensure that the medication is kept out of children's reach to prevent accidental consumption.

Following are the quick tips for Ezetimibe 10mg, Simvastatin 40mg Tablet:

• Always take the medication as directed by your doctor; do not alter the dosage.
• Take the tablet at the same time each day to maintain consistent blood levels.
• Swallow the tablet whole with a full glass of water; do not crush or chew.
• Ezetimibe and Simvastatin can be taken with or without food, but taking it with food may reduce the risk of side effects.
• Avoid consuming large amounts of grapefruit or grapefruit juice as it may affect the medication's effectiveness.
• Regularly monitor your liver function and blood sugar levels while on this medication.
• Inform your doctor about all medications you are taking to prevent potential drug interactions.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.