NEOMYCIN CREAM 15G (AMROS)

Neomycin, one of the active ingredients in Neomycin Cream, is an aminoglycoside antibiotic that primarily targets bacterial protein synthesis. Its mechanism of action involves binding to the 30S subunit of bacterial ribosomes, leading to misreading of tRNA, inhibiting protein synthesis, and ultimately resulting in bacterial cell death. Neomycin is particularly effective against a wide range of Gram-negative and Gram-positive bacteria, making it a valuable component in topical creams for treating bacterial skin infections. By disrupting bacterial protein synthesis, Neomycin helps to control and eliminate the bacteria causing the infection at the site of application.

Aminoglycoside antibiotic

Cream

The following are the uses of Neomycin Cream:

• Used for treating bacterial skin infections, such as impetigo or cellulitis.
• Used for preventing skin infections in minor cuts, scrapes, or burns.
• Used for reducing the risk of infection after surgery or invasive procedures.
• Used for managing skin conditions like eczema or dermatitis when bacterial infection is present.
• Used for aiding wound healing by preventing bacterial colonization.
• Used for alleviating symptoms of infected insect bites or stings.
• Used for treating folliculitis, an infection of the hair follicles.
• Used for providing topical antibacterial coverage in various skin-related issues.

In the case of an overdose of Neomycin Cream, it is important to recognize that topical creams are generally less likely to cause severe adverse effects compared to ingested medications. However, excessive use can lead to skin irritation, redness, and discomfort at the application site. If you suspect an overdose, wash the affected area with mild soap and water, and discontinue use. Consult a healthcare professional if symptoms persist or worsen, as they can provide guidance and recommend appropriate treatment options.

In the case of a missed dose of Neomycin Cream, it is important to apply the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed application and continue with your regular schedule. Do not apply extra cream to make up for the missed dose, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to proceed, as they may advise you to restart the medication or provide alternative instructions.

To use Neomycin Cream, gently clean and dry the affected skin area, then apply a thin layer of the cream, typically 2-3 times a day or as directed by your healthcare provider, and gently rub it into the skin, avoiding contact with eyes and open wounds.

Here are the conditions or situations when Neomycin Cream should not be used:

• Do not use if you are allergic to Neomycin, any other antibiotics from the aminoglycoside family, or any of the cream's ingredients.
• Avoid using Neomycin Cream if you have a history of hearing loss or balance disorders (vestibular toxicity).
• Contraindicated in individuals with a known sensitivity or allergy to other topical antibiotics.
• Not recommended for patients with kidney disease or impaired kidney function.
• Do not use Neomycin Cream on large areas of burned or damaged skin.
• Avoid using it on skin with open wounds or severe infections.
• Do not apply near the eyes, ears, or mouth, and do not ingest.
• Neomycin Cream is not suitable for long-term use due to the risk of bacterial resistance.

The side effects of Neomycin Cream may include:

• Skin irritation or redness at the application site
• Itching or rash
• Dryness or peeling of the skin
• Allergic reactions, such as hives or swelling
• Burning or stinging sensation
• Increased skin sensitivity to sunlight
• Hearing loss (in rare cases)

Following are the precautions and warnings for Neomycin Cream:

• Avoid using Neomycin Cream if you have a known allergy or sensitivity to any of its ingredients, including neomycin sulfate or other aminoglycoside antibiotics.
• Do not apply the cream near your eyes, ears, or mouth as it is meant for external use only on intact skin.
• Do not use the cream for extended periods without medical supervision, as prolonged use may lead to the overgrowth of resistant organisms.
• Do not use on large areas of the body or on deep, open, or puncture wounds without medical advice.
• Discontinue use and consult a doctor if you experience signs of skin irritation, such as redness, itching, or swelling.
• Keep out of reach of children. If accidentally ingested, seek immediate medical attention.
• Neomycin can be absorbed through the skin and may rarely cause kidney damage or hearing loss, especially with prolonged use or in individuals with kidney problems. Regular monitoring may be required in such cases.

Following are the drug interactions for Neomycin Cream:

• Topical corticosteroids, Prolonged use of Neomycin with corticosteroids may increase the risk of skin atrophy and other adverse effects.
• Systemic antibiotics, Absorption of Neomycin through the skin can occur, leading to potential interactions with systemic antibiotics, especially aminoglycosides, affecting kidney function.
• Anticoagulants, Neomycin may enhance the anticoagulant effect of medications like warfarin, requiring close monitoring of blood clotting time.
• Live vaccines, Neomycin may reduce the effectiveness of live vaccines such as measles or oral polio, if administered concurrently.
• Neuromuscular blocking agents, Neomycin can potentiate the effects of these agents, leading to prolonged neuromuscular blockade.
• Drugs affecting renal function, Neomycin elimination is primarily renal, so drugs that affect kidney function may alter Neomycin levels.
• Other topical medications, Concomitant use of multiple topical medications may increase the risk of skin irritation or alter the absorption of Neomycin.

Following are the food interactions to be aware of when using Neomycin Cream:

• Avoid consuming large amounts of high-protein foods like meat, fish, and eggs while using Neomycin Cream, as protein-rich diets can reduce the effectiveness of the antibiotic.
• Limit dairy products, as they can decrease the absorption of Neomycin.
• Avoid grapefruit and grapefruit juice as they can increase the levels of Neomycin in the blood, potentially leading to increased side effects.
• Alcoholic beverages should be avoided as they may exacerbate skin dryness and irritation, which are possible side effects of Neomycin Cream.
• Caffeine intake should be monitored as it may interact with Neomycin, potentially causing increased side effects such as nervousness and rapid heartbeat.
• Foods high in sugar may reduce the effectiveness of Neomycin, so it's advisable to limit sugary treats and beverages.
• Certain vegetables like beans, peas, and spinach contain high levels of vitamin K, which can interfere with the antibiotic's action, and should be consumed in moderation.
• Always consult with your healthcare provider or pharmacist for specific dietary recommendations while using Neomycin Cream to ensure optimal treatment outcomes.

Neomycin Cream should be stored in a cool and dry place, preferably at room temperature, away from direct exposure to sunlight, heat, and moisture. The cream should be kept in its original container, securely sealed, to maintain its integrity and prevent contamination. It is crucial not to store the cream in the bathroom or near any heat-emitting appliances. Always check the expiration date, and if the cream has passed its expiry, do not use it and dispose of it appropriately. For proper disposal methods, consult a pharmacist or healthcare professional to ensure safe and environmentally friendly practices. Keep the cream out of children's reach to prevent accidental ingestion or misuse.

Following are the quick tips for Neomycin Cream:

• Clean and dry the affected area before applying the cream.
• Apply a thin layer of cream to the skin as directed by your doctor.
• Gently rub the cream into the skin until it is thoroughly absorbed.
• Avoid applying the cream to broken or irritated skin.
• Wash your hands after application to prevent accidental contact with eyes or mouth.
• Do not cover the treated area with bandages or tight clothing to allow the skin to breathe.
• Store the cream at room temperature, away from direct sunlight and moisture.