Neotret (10mg) 10 Capsules

Acitretin is a retinoid medication primarily used for its effects on skin cells. Its mechanism of action involves binding to cellular retinoic acid receptors (RARs), which are nuclear receptors that regulate gene expression. Upon binding to RARs, acitretin forms heterodimers with retinoid X receptors (RXRs), and this complex then binds to specific DNA sequences called retinoic acid response elements (RAREs) in the promoter regions of target genes. This binding modulates gene transcription, leading to various effects on cellular processes. One of the primary effects of acitretin is the regulation of keratinocyte proliferation and differentiation, which helps normalize epidermal growth and reduce the symptoms associated with certain skin conditions. It also influences the production of pro-inflammatory mediators, leading to anti-inflammatory effects. Additionally, acitretin can affect the metabolism of lipids and proteins in the skin, contributing to its therapeutic benefits in dermatological disorders.

Acitretin 10mg

Retinoid

Capsule

The following are the uses of Acitretin 10mg Capsule:

• Used for treating severe psoriasis and related skin conditions, effectively reducing skin cell growth.
• Used to alleviate symptoms of severe psoriasis, providing relief from itching and scaling.
• Used to treat palmoplantar keratoderma, a skin disorder affecting the palms and soles.
• Used in the management of chronic hand eczema, improving skin texture and reducing inflammation.
• Used to address certain types of skin cancer, particularly for patients with basal cell nevus syndrome.
• Used to prevent skin cancer recurrence by controlling abnormal cell growth.
• Used to treat severe acne that has not responded to other treatments, reducing inflammation and promoting skin healing.
• Used for managing skin conditions with thick, scaly plaques, offering targeted relief.

In the case of an overdose of Acitretin 10mg Capsules, it is important to recognize the potential severity of the situation. Symptoms may include an increased risk of birth defects, skin peeling, and elevated liver enzymes. Promptly seek medical assistance and provide the healthcare provider with information regarding the number of capsules ingested. They will offer guidance and determine the most appropriate course of action to ensure the well-being of the individual. It is crucial to act swiftly in such situations.

In the case of a missed dose of Acitretin 10mg Capsule, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may advise you to restart the medication or adjust the dosage accordingly. It is essential to maintain consistency with this medication for optimal results.

To take Acitretin 10mg Capsules, swallow the capsule whole with a full glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, typically once daily or as directed.

Following are the conditions/situations when Acitretin 10mg Capsule should not be taken:

• Should not be used in individuals with a known allergy to Acitretin or any retinoid medications.
• Contraindicated in pregnant women or those planning to become pregnant due to the high risk of birth defects.
• Not suitable for breastfeeding mothers as it may pass into breast milk and harm the nursing infant.
• Should not be used in patients with severe liver disease or impaired liver function.
• Avoid in individuals with severe kidney disease or those on dialysis.
• Contraindicated in children and adolescents, as it can cause skeletal growth retardation.
• Do not use if you have uncontrolled cholesterol or triglyceride levels.
• Should be avoided in patients with severe depression or a history of psychiatric disorders.
• Not recommended for individuals with untreated vitamin A deficiency.
• Do not use if you have a history of severe gastrointestinal disorders or intestinal surgery.

The side effects of Acitretin 10mg Capsule may include:

• Dryness of the skin, lips, and eyes
• Itching
• Skin peeling or scaling
• Hair loss
• Joint or muscle pain
• Changes in liver function
• Increased sensitivity to sunlight

Following are the precautions and warnings for Acitretin 10mg Capsule:

• This medication is not recommended for pregnant women or those planning to become pregnant. It can cause severe birth defects and must be avoided during pregnancy and for at least 3 years after discontinuation.
• Women of childbearing age must use two effective forms of contraception simultaneously for at least one month before, during, and for at least 3 years after treatment.
• Acitretin may increase cholesterol and triglyceride levels, so regular monitoring is necessary, especially for patients with pre-existing lipid abnormalities.
• It may cause liver enzyme elevations, so liver function tests should be performed before and during treatment.
• Avoid alcohol consumption while taking Acitretin as it can increase the risk of liver damage.
• Patients with kidney disease should use this medication with caution, as dosage adjustments may be required.
• This medication may cause photosensitivity, making the skin more sensitive to sunlight. Avoid prolonged sun exposure and use protective measures when outdoors.
• Keep this medication out of the reach of children and pets, and store it in a safe and secure place.

Following are the drug interactions for Acitretin 10mg Capsule:

• Concomitant use with other retinoids, such as isotretinoin or tretinoin, may increase the risk of cumulative toxicity and adverse effects.
• Acitretin can enhance the anticoagulant effect of warfarin, requiring close monitoring of INR and potential dose adjustments.
• The efficacy of hormonal contraceptives may be reduced, and alternative contraceptive methods should be considered.
• It may increase the risk of nephrotoxicity when used with cyclosporine, requiring careful monitoring of kidney function.
• Concomitant use with methotrexate can lead to increased methotrexate toxicity, and close monitoring of methotrexate levels is necessary.
• Vitamin A supplements should be avoided to prevent hypervitaminosis A and potential toxicity.
• Alcohol consumption may increase the risk of liver toxicity and should be minimized or avoided during treatment.

Following are the food interactions for Acitretin 10mg Capsule:

• Avoid excessive Vitamin A intake, as Acitretin is a Vitamin A derivative, and high Vitamin A levels can lead to toxicity, causing symptoms like headache, blurred vision, and bone pain.
• Restrict alcohol consumption as it can increase the risk of liver damage and may also reduce the effectiveness of the medication.
• Grapefruit and grapefruit juice should be avoided, as they can alter the metabolism of Acitretin, leading to increased blood levels and potential toxicity.
• High-fat meals may delay the absorption of Acitretin, but this effect is usually not clinically significant.
• Dairy products like milk and cheese can interfere with the absorption of Acitretin, so consider taking the medication on an empty stomach or as directed by your doctor.
• Vitamin E supplements should be used with caution as they can enhance the effects of Acitretin and increase the risk of side effects.
• Avoid high-dose fish oil supplements as they may increase the risk of bleeding when combined with Acitretin.
• Always inform your healthcare provider about your diet and any supplements you are taking to ensure safe and effective use of Acitretin.

Acitretin 10mg capsules should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. Keep the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. It is crucial to avoid exposing the capsules to extreme temperatures, so steer clear of storage areas like bathrooms, or near heat sources such as stoves or radiators. Always check the expiration date, and if the medication is no longer needed or has expired, proper disposal is essential. Do not dispose of it via toilet flushing or drainage systems; instead, consult a pharmacist or healthcare professional for safe disposal guidelines. Lastly, keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Acitretin 10mg Capsule:

• Take the medicine as directed by your doctor, usually once daily with or after a meal.
• Ensure you understand the dosage instructions and duration of treatment.
• Regular blood tests are required to monitor liver function and blood cell counts.
• Avoid alcohol consumption as it may increase the risk of liver damage.
• Inform your doctor about all medications you're taking to prevent potential drug interactions.
• Women should avoid pregnancy during and for at least 3 years after treatment due to potential birth defects.
• Store the capsules in a cool, dry place, away from direct sunlight and moisture.