Nepatek (0.1%) 5ml Eye Suspension

Nepafenac is a non-steroidal anti-inflammatory drug (NSAID) that is used in the form of an eye syrup or suspension to reduce pain and inflammation associated with eye conditions. Its mechanism of action primarily involves the inhibition of cyclooxygenase (COX) enzymes, particularly COX-2. When applied to the eye, nepafenac penetrates the corneal and scleral tissues. It is then hydrolyzed to form its active metabolite, amfenac, which is a potent inhibitor of COX enzymes. By blocking the action of COX-2, nepafenac reduces the production of prostaglandins, which are key mediators of inflammation and pain. This inhibition of prostaglandin synthesis helps alleviate ocular inflammation, reduce pain, and minimize the effects of conditions such as cataract surgery, ocular pain, and inflammation associated with eye injuries or surgeries.

Nonsteroidal anti-inflammatory drug (NSAID)

Drop

The following are the uses of Nepafenac Eye Syrup/Suspension:

• Used for reducing pain and inflammation after eye surgery
• Used to treat post-operative eye swelling and irritation
• Used for managing eye pain and discomfort in patients with cataract surgery
• Used to relieve eye redness and itching
• Used for preventing further eye damage and promoting healing
• Used to treat ocular allergies and reduce associated symptoms
• Used for short-term relief of eye irritation and foreign body sensation

In the case of an overdose of Nepafenac Eye Syrup/Suspension, it is important to act swiftly. Rinse the affected eye(s) thoroughly with warm water for several minutes to dilute and remove any excess medication. Seek medical advice promptly, even if no immediate symptoms are apparent. Contact a healthcare professional or poison control center for guidance, as they can provide specific instructions for managing the overdose based on the individual's condition and the amount ingested.

In the case of a missed dose of Nepafenac Eye Syrup/Suspension, it is important to administer the medication as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to get back on track with your treatment plan. Always keep a record of your medication schedule to minimize the chances of missing doses.

To administer Nepafenac Eye Syrup/Suspension, gently shake the bottle, tilt your head back, and instill the prescribed number of drops into the affected eye(s) using the dropper provided, then close your eyes for a few minutes to allow the medication to absorb.

Following are the conditions when Nepafenac Eye Syrup/Suspension should not be used:

• Not for patients with a known allergy or hypersensitivity to Nepafenac or any other ingredients in the eye medication.
• Avoid using if you have a history of allergic reactions to NSAIDs (non-steroidal anti-inflammatory drugs) in the past.
• Not suitable for individuals with severe eye infections or injuries until the issue is resolved.
• Do not use if you have recently undergone eye surgery unless advised by your eye doctor.
• Not recommended for patients with corneal ulcers or defects.
• Avoid using if you have a history of corneal problems or thinning.
• Should not be used in patients with a history of severe dry eye syndrome.
• Not suitable for individuals with a history of severe eye inflammation or uveitis.
• Avoid using if you have a history of herpes viral infections in the eye.
• Not recommended during pregnancy or breastfeeding without medical advice.

The side effects of Nepafenac Eye Syrup/Suspension may include:

• Eye burning or stinging sensation
• Redness or itching of the eyes
• Increased sensitivity to light (photophobia)
• Blurred vision or changes in vision
• Eye discharge or tearing
• Dry eyes
• Swelling or inflammation of the eyelids

Following are the precautions and warnings for Nepafenac Eye Syrup/Suspension:

• Do not use if you are allergic to Nepafenac or any other ingredients in the medication.
• This medication is for ophthalmic use only; do not swallow or inject.
• Avoid wearing contact lenses while using the eye drops, as it may cause irritation.
• Inform your doctor if you have a history of eye surgery or any other eye conditions before using this medication.
• Discontinue use and seek medical attention if you experience severe eye pain, changes in vision, or signs of an allergic reaction.
• Keep out of reach of children. Store in a cool, dry place, away from direct sunlight.
• Consult a doctor or pharmacist if you are taking other eye medications to avoid potential interactions.

Following are the drug interactions for Nepafenac Eye Syrup/Suspension:

• Nepafenac may increase the risk of bleeding when used with anticoagulants like warfarin or antiplatelet drugs (e.g., aspirin, clopidogrel).
• It can enhance the effects of other nonsteroidal anti-inflammatory drugs (NSAIDs), leading to increased adverse effects.
• Topical steroids and Nepafenac used together may increase the risk of ocular side effects and corneal complications.
• Probenecid, a medication used for gout, can affect the excretion of Nepafenac, potentially increasing its concentration in the body.
• The eye drop formulation may contain benzalkonium chloride, which can be removed by contact lenses, so caution is advised for contact lens wearers.
• Nepafenac may increase the intraocular penetration of other topical ophthalmic medications, affecting their concentration in the eye.
• Drugs affecting renal function can impact Nepafenac elimination, as it is primarily excreted by the kidneys.

Following are the food interactions for Nepafenac Eye Syrup/Suspension:

• Nepafenac eye drops can cause an increased risk of bleeding, so avoid foods rich in vitamin K like spinach, kale, and broccoli, as they can counteract the medication's effects.
• It is advisable to limit the consumption of fatty foods as they may interfere with the medication's absorption and increase the risk of gastrointestinal side effects.
• Alcohol consumption should be minimized as it can increase the risk of stomach irritation and potential liver-related issues.
• Grapefruit and grapefruit juice should be avoided as they may alter the metabolism of the medication, leading to increased side effects.
• Caffeine intake should be monitored as it may exacerbate eye irritation and dryness.
• Avoid spicy foods as they can potentially worsen eye discomfort and inflammation.
• Sugary foods and beverages might increase the risk of ocular infections and should be consumed in moderation.
• Stay hydrated by drinking plenty of water to maintain eye moisture and reduce irritation.

Nepafenac Eye Syrup/Suspension should be stored with caution, ensuring a cool and dry environment, preferably at room temperature, shielded from direct sunlight and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. Avoid bathrooms or proximity to heat sources like stoves, as temperature fluctuations can impact the medication's efficacy. Prioritize medication safety by checking the expiration date and disposing of any unused or expired syrup responsibly; refrain from flushing or pouring it down the drain. Consult a pharmacist for guidance on proper disposal methods, and ensure the medication is stored securely, out of children's reach, to prevent accidental consumption.

Following are the quick tips for Nepafenac Eye Syrup/Suspension:

• Wash your hands thoroughly before administering the eye drops to maintain hygiene.
• Tilt your head back, gently pull down your lower eyelid, and instill the prescribed number of drops into the eye.
• Avoid touching the dropper tip to your eye or any surface to prevent contamination.
• Close your eyes gently and apply light pressure to the inner corner of the eye for a few seconds to minimize drainage.
• If using other eye medications, wait at least 5 minutes before applying the next medication to ensure proper absorption.
• Store the eye drops at room temperature, away from direct sunlight and moisture.
• Do not use the eye drops if the solution changes color or becomes cloudy.