Nerisone (0.1%) 10g Cream

Diflucortolone, the active ingredient in Diflucortolone Cream, is a potent synthetic corticosteroid. Its primary mechanism of action involves binding to cytoplasmic glucocorticoid receptors in target cells. Upon binding, the corticosteroid-receptor complex migrates to the cell nucleus, where it modulates gene expression by regulating the transcription of specific genes. This leads to the suppression of various inflammatory processes. Diflucortolone reduces inflammation by inhibiting the production of pro-inflammatory mediators, such as cytokines and prostaglandins, and by suppressing the immune response by decreasing the activity and number of inflammatory cells at the site of application. The drug also stabilizes cell membranes, reducing vascular permeability and the migration of inflammatory cells to the area of inflammation.

Corticosteroid.

Cream

The following are the uses of Diflucortolone Cream:

• Used for treating inflammatory skin conditions like eczema and psoriasis.
• Used to relieve redness, itching, and inflammation.
• Used for its potent anti-inflammatory and immunosuppressive properties on the skin.
• Used to manage skin conditions that have not responded to weaker corticosteroids.
• Used for short-term treatment to minimize side effects.
• Used for its ability to penetrate the skin and reduce skin cell production.
• Used for providing relief from symptoms and improving skin appearance.

In the case of an overdose of Diflucortolone Cream, it is important to remain calm and take appropriate action. The severity of symptoms may vary depending on the amount applied and the individual's sensitivity. If a large amount has been applied, it may cause a temporary burning or itching sensation at the application site. In such instances, promptly wash the affected area with mild soap and water to remove any excess cream. Consult a healthcare professional for further guidance if symptoms persist or worsen.

In the case of a missed dose of Diflucortolone Cream, it is important to apply the medication as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed one and continue with your regular application schedule. Do not apply extra cream to make up for the missed dose, as this may increase the risk of side effects. If you frequently miss doses, it's best to consult your healthcare professional for guidance on how to adjust your dosing schedule to ensure the medication's effectiveness.

To apply Diflucortolone Cream, clean and dry the affected skin area, then gently rub a thin layer of the cream onto the skin, ensuring it covers the entire affected area, usually once or twice a day or as directed by your doctor.

Here are the situations when Diflucortolone Cream should not be used:

• Must not be used if you are allergic to diflucortolone or any other similar corticosteroid medications.
• Avoid using it if you have a widespread skin infection, unless directed by a doctor.
• Not suitable for individuals with acne, rosacea, or perioral dermatitis.
• Do not use on skin that is broken, infected, or has open wounds.
• Contraindicated for the treatment of skin problems in children under 1 year of age.
• Do not use on the face, unless prescribed by a doctor.
• Should not be used for long periods of time without medical supervision.

The side effects of Diflucortolone Cream may include:

• Skin irritation or itching at the application site
• Burning or stinging sensation
• Thinning of the skin
• Acne or pimples
• Increased hair growth in the treated area
• Contact dermatitis (red, itchy skin)
• Allergic reactions (rash, hives, difficulty breathing)
• Prolonged use may lead to stretch marks or skin discoloration.

Following are the precautions and warnings:

• Diflucortolone Cream is for external use only and should not be ingested or applied to the eyes or mucous membranes.
• Avoid using the cream on infected or open wounds, and do not use it for extended periods without medical supervision.
• It is important to inform your doctor if you have a history of skin disorders, allergies, or other medical conditions before using this medication.
• Do not cover the treated area with airtight dressings or bandages as it may increase the absorption of the medication.
• Wash your hands thoroughly after applying the cream to avoid accidental transfer to other areas, especially the eyes and mouth.
• This medication may cause thinning of the skin, so use it sparingly and only as directed by your doctor.
• If you are pregnant, breastfeeding, or planning a pregnancy, consult your healthcare provider as the potential risks and benefits should be carefully considered.
• Keep Diflucortolone Cream out of the reach of children and pets to prevent accidental ingestion.

Following are the drug interactions for Diflucortolone Cream:

• Avoid combining with other topical corticosteroids as it may increase the risk of skin atrophy and other adverse effects.
• Diflucortolone can interact with oral corticosteroids, potentially leading to increased systemic corticosteroid effects and suppression of the hypothalamic-pituitary-adrenal (HPA) axis.
• The use of Diflucortolone with immunosuppressants may result in additive immunosuppression and increased risk of infection.
• Combining with oral anticoagulants may increase the risk of bruising and bleeding.
• Antidiabetic medication effects may be altered, as Diflucortolone can increase blood glucose levels.
• It may reduce the effectiveness of live vaccines due to its immunosuppressive properties.
• There is a potential for increased risk of systemic toxicity when used with other potent topical medications.

Following are the food interactions for Diflucortolone Cream:

• Diflucortolone may lower your immune system, so it is advised to avoid live vaccines or immunizations without your doctor's approval.
• Alcohol is not known to interact directly with Diflucortolone Cream, but it's generally recommended to limit alcohol consumption when using any medication to avoid potential interactions and health risks.
• Grapefruit and grapefruit juice should be consumed with caution as they can inhibit certain enzymes in the liver, potentially affecting the metabolism of drugs, although this interaction is less likely with topical medications.
• Caffeine-rich foods and beverages like coffee, tea, and energy drinks should be consumed in moderation, as they can influence skin hydration and potentially impact the skin's barrier function.
• Spicy foods may cause skin flushing and irritation, especially if you have sensitive skin, so consider limiting spicy food intake while using Diflucortolone Cream.
• Avoid sharing utensils and beverages to prevent the spread of any potential infections, as Diflucortolone may lower your body's ability to fight them.
• Certain food allergies may trigger skin reactions; if you have known allergies, avoid those specific foods to prevent potential skin issues.
• Always maintain a balanced diet to support overall skin health and healing while using Diflucortolone Cream.

Diflucortolone Cream should be stored carefully to maintain its effectiveness and ensure safe disposal. Store the cream in a cool, dry place, preferably at room temperature, away from direct sunlight and heat sources like ovens or radiators. Keep the cream in its original container, tightly sealed, to prevent contamination. Always check the expiration date, and never use the cream past its expiry. When disposing of the cream, avoid flushing it down the toilet or sinks. Instead, consult your pharmacist or local waste management guidelines for appropriate disposal methods. It is crucial to keep the cream out of children's reach to prevent accidental exposure or ingestion.

Here are the quick tips for Diflucortolone Cream:

• Wash your hands before applying the cream to ensure a clean application.
• Apply a thin layer to the affected area, gently rubbing it into the skin.
• Use the cream as directed by your doctor, typically 2-3 times daily.
• Avoid applying it on broken or infected skin.
• Do not cover the treated area with a bandage or wrap, unless directed by your doctor.
• Wash your hands after application to avoid spreading the medication.
• Store the cream at room temperature, away from direct sunlight and moisture.