Nerisone Forte (0.3%) 10g Skin Ointment

Diflucortolone ointment, a potent synthetic corticosteroid, exerts its therapeutic effects primarily by modulating the immune system and reducing inflammation. It binds to corticosteroid receptors within cells, triggering a cascade of intracellular events. This leads to the suppression of various inflammatory mediators, such as prostaglandins and leukotrienes, which are responsible for causing redness, swelling, and discomfort. By inhibiting the release of these inflammatory substances, diflucortolone effectively reduces inflammation and alleviates symptoms associated with certain skin conditions. The ointment formulation allows for direct application to the affected area, ensuring localized action and minimizing systemic absorption.

Corticosteroid ointment.

Ointment

The following are the uses of Diflucortolone Ointment:

• Used for treating inflammatory skin conditions like eczema, psoriasis, and dermatitis.
• Used to reduce redness, swelling, and itching associated with skin inflammation.
• Used for its potent anti-inflammatory properties, quickly relieving skin irritation.
• Used in cases where milder corticosteroids are ineffective, offering stronger relief.
• Used to manage acute flare-ups, providing rapid improvement in symptoms.
• Used for short-term treatment, typically 7-14 days, to minimize side effect risks.
• Used with caution in sensitive areas, avoiding the face, eyes, and broken skin.

In the case of an overdose of Diflucortolone Ointment, it is important to remain calm and seek medical advice promptly. Overuse of this medication can lead to increased side effects, such as skin irritation, redness, or a burning sensation. While rare, excessive application may result in more severe symptoms, including difficulty breathing or swelling of the face and throat. It is advisable to contact a healthcare professional or a poison control center for guidance on managing the situation effectively.

In the case of a missed dose of Diflucortolone Ointment, it is important to apply the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one. Do not double the dose to make up for a missed application. If you miss multiple doses, contact your healthcare professional for advice on how to safely resume the treatment without compromising its effectiveness. Remember, maintaining a consistent dosing schedule is crucial for the medication's success.

To apply Diflucortolone Ointment, clean and dry the affected skin area, then gently apply a thin layer of the ointment, ensuring it covers the affected skin completely, and follow the prescribed dosage and application frequency as directed by your healthcare provider.

Here are the conditions or situations when Diflucortolone Ointment should not be used:

• Should not be used in individuals with a known allergy or hypersensitivity to Diflucortolone or other corticosteroids.
• Contraindicated in patients with certain skin infections, such as viral, fungal, or bacterial infections, unless these infections are being treated simultaneously.
• Not suitable for individuals with skin conditions like rosacea, acne, or perioral dermatitis.
• Should not be used on skin with open wounds, burns, or broken skin.
• Not recommended for long-term use, especially on sensitive areas like the face or groin.
• Contraindicated in individuals with a history of skin thinning (atrophy) due to corticosteroid use.
• Should be avoided in patients with a history of allergic reactions to any of the ointment's ingredients.
• Not suitable for the treatment of diaper rash in infants.

The side effects of Diflucortolone Ointment may include:

• Skin irritation or burning at the application site
• Thinning of the skin
• Stretch marks
• Increased hair growth in the treated area
• Easy bruising
• Acne or pimples
• Allergic reactions (skin rash, itching, redness)
• Prolonged use may lead to skin discoloration or pigmentation changes.

Following are the precautions and warnings:

• Diflucortolone Ointment is for external use only and should not be ingested or applied to the eyes or mucous membranes.
• Avoid using the ointment on infected or open wounds.
• It is important to complete the full course of treatment as prescribed by your doctor, even if symptoms improve.
• Do not use the ointment for longer than recommended, as prolonged use may lead to skin thinning and other adverse effects.
• Wash your hands thoroughly before and after applying the ointment to avoid spreading the medication to other areas.
• Inform your doctor if you have a history of skin disorders, allergies, or are using other topical medications to ensure safe usage.
• This medication may cause temporary skin irritation, burning, or itching at the application site, but if these symptoms persist or worsen, consult your healthcare professional.
• Diflucortolone Ointment should be used with caution in children, and only under the supervision of a healthcare provider.

Following are the drug interactions for Diflucortolone Ointment:

• Diflucortolone may interact with other topical corticosteroids, increasing the risk of skin atrophy and other local side effects.
• The use of other immunosuppressants alongside Diflucortolone can further weaken the immune system, making patients more susceptible to infections.
• Caution is advised when using Diflucortolone with other medications that are metabolized by cytochrome P450 enzymes, as it may lead to increased drug levels and potential side effects.
• The effect of Diflucortolone may be reduced by potent CYP3A4 inducers, which can decrease its therapeutic efficacy.
• May increase risk of bleeding when used with Diflucortolone due to skin thinning.
• Topical corticosteroids like Diflucortolone can increase blood glucose levels, requiring adjustments in antidiabetic therapy.
• Diflucortolone may suppress the immune response, reducing the effectiveness of live vaccines.

Following are the food interactions to be aware of when using Diflucortolone Ointment:

• Avoid consuming grapefruit and grapefruit juice as they may interfere with the medication's metabolism, potentially increasing the drug's concentration in the body and enhancing its side effects.
• Alcohol consumption should be limited or avoided. Alcohol can increase the risk of gastrointestinal side effects and may also interact with the medication's anti-inflammatory properties.
• High-fat meals may slightly delay the absorption of the active ingredient, but this is unlikely to significantly impact the overall effectiveness of the treatment.
• Dairy products are generally safe, but if you have a known milk protein allergy or lactose intolerance, exercise caution as these products may exacerbate skin conditions.
• Spicy foods are not directly related to Diflucortolone, but they might irritate sensitive skin, so it's advisable to moderate consumption during treatment.
• Avoid excessive caffeine intake, as it may dehydrate the skin, potentially reducing the effectiveness of the ointment and causing discomfort.
• Staying well-hydrated is essential. Drink plenty of water to support overall skin health and aid in the healing process.
• There are no specific food restrictions with Diflucortolone Ointment, but maintaining a balanced diet can contribute to overall skin health and faster recovery.

Diflucortolone Ointment should be stored in a secure and controlled environment, preferably in a cool and dry place at room temperature, ensuring it is protected from direct sunlight and moisture. It is crucial to keep the ointment in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. Avoid exposing the ointment to extreme temperatures, such as those found near heat sources or in bathrooms, as this can impact its effectiveness. Regularly check the expiration date, and properly dispose of any unused or expired ointment by following local guidelines or consulting a pharmacist. When discarding the medication, avoid flushing it down the toilet or pouring it into drains. Keep the ointment out of children's reach to prevent accidental contact or ingestion.

Following are the quick tips for Diflucortolone Ointment:

• Clean and dry the affected area before applying the ointment.
• Use a thin layer and gently rub it into the skin, avoiding sensitive areas like eyes and mouth.
• Wash your hands after application to prevent accidental transfer.
• Avoid covering the treated area with tight clothing or bandages to allow the skin to breathe.
• Do not apply to broken or infected skin; consult a doctor if the condition worsens.
• Store the ointment at room temperature, away from direct sunlight and moisture.
• Consult a healthcare professional if you have any concerns or questions regarding usage.