Neufol 30 Softgels Capsule

L-Methylfolate, the active ingredient in L-Methylfolate capsules, serves as a biologically active form of folate (vitamin B9). Its mechanism of action revolves around directly participating in various biochemical reactions as a methyl donor. This compound plays a crucial role in the synthesis of DNA, RNA, and S-adenosylmethionine (SAMe), a vital molecule involved in numerous methylation processes. By supplying methyl groups, L-methylfolate contributes to the regulation of gene expression, neurotransmitter production, and the maintenance of proper neurological function. This mechanism is particularly significant in individuals with genetic variations affecting folate metabolism, ensuring an adequate supply of this essential nutrient for optimal cellular processes.

Folate analog.

Capsule

The following are the uses of L Methyfolate Capsule:

• Used for treating folate deficiency, ensuring proper brain function, and supporting mental health.
• Used for promoting healthy fetal development during pregnancy, reducing the risk of neural tube defects.
• Used for managing high homocysteine levels, a risk factor for cardiovascular diseases.
• Used for supporting cardiovascular health and maintaining healthy blood vessels.
• Used for boosting energy levels and combating fatigue, especially in individuals with folate deficiency.
• Used for enhancing the effectiveness of certain medications, such as methotrexate, by reducing side effects.
• Used for supporting overall cellular function and DNA synthesis.
• Used for potentially improving mood and cognitive function in individuals with depression or cognitive impairment.

In the case of an overdose of L-Methylfolate Capsules, it is important to remain calm and seek medical advice promptly. Symptoms of an overdose may include nausea, dizziness, and fatigue. Do not induce vomiting unless instructed by a healthcare professional. Call a doctor or poison control center for guidance, as they can provide specific instructions based on the amount ingested and individual factors. Quick action can help ensure the best possible outcome in the event of an overdose.

In the case of a missed dose of L-Methylfolate Capsule, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare professional for advice on how to safely adjust your medication regimen. It is generally recommended to take the medication at the same time each day to maintain consistent levels in your body.

To take L-Methylfolate capsules, swallow the capsule whole with a glass of water, preferably at the same time each day. It is best to take the capsule on an empty stomach, either 1 hour before or 2 hours after a meal, as directed by your healthcare professional. Ensure you follow the prescribed dosage and do not crush, chew, or break the capsule to maintain its effectiveness.

Here are the conditions and situations when L-Methylfolate Capsule should not be taken:

• Avoid use if you have a known hypersensitivity or allergy to L-Methylfolate or any of its excipients.
• Do not take if you have anaphylactic reactions or a history of anaphylaxis.
• Contraindicated in individuals with pernicious anemia, as it is not a substitute for the treatment of vitamin B12 deficiency.
• Should not be used as a sole treatment for depression, it is an adjunctive therapy.
• Not recommended for those with advanced renal failure or undergoing hemodialysis.
• Avoid use if you have a rare genetic disorder called Leber's disease.
• Do not exceed the recommended dosage, as high doses may lead to adverse effects.

The side effects of L-Methylfolate Capsule may include:

• Nausea
• Headache
• Dizziness
• Diarrhea
• Sleep disturbances (insomnia or vivid dreams)
• Itching or rash
• Anxiety or irritability
• Joint pain

Following are the precautions and warnings for L-Methylfolate Capsule:

• Not suitable for individuals with a known hypersensitivity or allergy to L-Methylfolate or any of its ingredients.
• Patients with a history of psychiatric disorders should use with caution, as it may exacerbate symptoms in some cases.
• Those with a history of seizures or epilepsy should exercise caution and consult a healthcare professional before use.
• May cause mild gastrointestinal discomfort in some individuals; if symptoms persist or worsen, consult a doctor.
• L-Methylfolate may interact with certain medications, including anticonvulsants and methotrexate, so a doctor's advice is essential for concurrent use.
• Not recommended for children unless prescribed by a healthcare provider, as dosage adjustments may be necessary.
• Patients with conditions affecting the absorption of folate should consult a healthcare professional for proper monitoring.
• Elderly individuals may require lower doses, as they are more susceptible to side effects.

Following are the drug interactions for L-Methylfolate Capsule:

• L-Methylfolate may decrease the effectiveness of methotrexate, a drug used in cancer and autoimmune diseases, by interfering with its metabolism.
• It can interact with phenytoin, an anti-seizure medication, leading to reduced phenytoin levels and potential loss of seizure control.
• When combined with certain antibiotics like trimethoprim-sulfamethoxazole, L-Methylfolate may reduce the antibiotic's efficacy.
• Anticonvulsants like phenobarbital can decrease L-Methylfolate levels, potentially reducing its therapeutic effects.
• The effectiveness of Levodopa, a Parkinson's disease medication, may be reduced when used with L-Methylfolate.
• Caution is advised when taking L-Methylfolate with oral contraceptives, as it may decrease the contraceptive's effectiveness.
• It can also interact with medications containing folic acid, potentially affecting the overall folate levels in the body.

Following are the food interactions for L-Methylfolate Capsule:

• Folate-rich foods like leafy green vegetables, citrus fruits, beans, and fortified cereals can be beneficial as they complement the supplement's effects, ensuring optimal folate levels.
• Consuming a varied and balanced diet can enhance the absorption of L-Methylfolate, ensuring its effectiveness.
• Limit or avoid high-dose vitamin B12 supplements, as excessive B12 intake may compete with folate absorption, potentially leading to imbalances.
• Avoid excessive alcohol consumption, as alcohol can interfere with folate metabolism and reduce the effectiveness of L-Methylfolate.
• Grapefruit and its juice may influence the absorption of certain medications; consult your healthcare provider for specific interactions.
• Dairy products, especially those fortified with calcium, might affect L-Methylfolate absorption when taken simultaneously. Consider spacing out the intake of dairy and the supplement.
• Antacid medications containing aluminum or magnesium can potentially reduce L-Methylfolate absorption. Discuss with your healthcare provider if you regularly use these medications.
• Certain medications, such as methotrexate, may interact with L-Methylfolate; always inform your healthcare provider about all the medications you are taking.

L-Methylfolate capsules should be stored in a cool, dry location, ideally at room temperature, protected from direct sunlight and moisture. It's crucial to keep the medication in its original container, securely sealed, to maintain its integrity and prevent contamination. Avoid storing it in humid environments like bathrooms, and steer clear of heat sources such as radiators or stoves, as extreme temperatures can impact the drug's effectiveness. Regularly check the expiration date, and if the medication is past its prime or no longer needed, do not flush it or pour it down the drain. Instead, consult a pharmacist or healthcare professional for the appropriate disposal method. Always keep medicines out of children's reach to prevent accidental consumption.

Following are the quick tips for L-Methylfolate Capsule:

• Take the capsule as directed by your doctor or pharmacist, typically once daily.
• Consume the capsule with or without food, but be consistent with your choice.
• Consider taking it at the same time each day to establish a routine.
• Swallow the capsule whole; do not crush, chew, or open it.
• If you have difficulty swallowing, ask your pharmacist about alternative formulations.
• Store the capsules in a cool, dry place, away from direct sunlight.
• Consult your healthcare provider if you have any concerns or experience side effects.