Neupred (15mg/5ml) 120ml Syrup

Prednisolone syrup or suspension, when administered orally, exerts its therapeutic effects through its potent anti-inflammatory and immunosuppressive properties. It is a synthetic corticosteroid that closely resembles the body's natural hormone cortisol. Prednisolone binds to intracellular glucocorticoid receptors, leading to the modulation of gene expression. This binding triggers a cascade of events, including the suppression of pro-inflammatory mediators such as cytokines and prostaglandins, inhibition of immune cell activation and migration, and reduction of capillary permeability. As a result, prednisolone helps to alleviate inflammation, reduce immune system responses, and provide symptomatic relief in various inflammatory and autoimmune conditions. The mechanism of action primarily involves the regulation of gene transcription, influencing the production of proteins involved in immune and inflammatory responses.

Corticosteroid.

Suspension

The following are the uses of Prednisolone 15mg Syrup/Suspension:

• Used for reducing inflammation and suppressing the immune system in children, making it effective for asthma, allergic reactions, and inflammatory conditions.
• Used to manage severe allergies and allergic reactions, providing quick relief from symptoms.
• Used in treating childhood asthma to reduce airway inflammation and prevent asthma attacks.
• Effective in managing inflammatory bowel diseases in children, helping to reduce gut inflammation.
• Used to alleviate symptoms of juvenile arthritis, reducing joint pain and swelling.
• Can be prescribed for autoimmune conditions like lupus, where it helps control the overactive immune response.
• Provides short-term relief in croup, a respiratory condition causing a distinctive cough and breathing difficulties.
• Used as a short-term treatment for various childhood inflammatory and allergic conditions, offering fast and effective relief.

In the case of an overdose of Prednisolone 15mg Syrup/Suspension, prompt action is necessary. Symptoms may include increased heart rate, dizziness, and severe headaches. If ingestion is recent, vomiting may be induced, but it is crucial to seek medical help immediately. Medical professionals may administer activated charcoal to prevent further absorption and provide supportive care to manage symptoms. Timely intervention is essential to prevent potential complications.

In the case of a missed dose of Prednisolone 15mg Syrup/Suspension, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication regimen without compromising its effectiveness. It is crucial to maintain consistency in taking your medication as prescribed.

To use Prednisolone 15mg Syrup/Suspension, shake the bottle well, measure the prescribed dose with a measuring device, and administer it orally once or twice a day as directed by your healthcare provider, ensuring accurate dosage for effective treatment.

Here are the conditions and situations when Prednisolone 15mg Syrup/Suspension should not be used:

• Avoid using if the patient has a known allergy to Prednisolone or any other steroid medications.
• Not suitable for individuals with systemic fungal infections.
• Contraindicated in patients with recent or active gastrointestinal ulcers or bleeding.
• Should not be used in patients with uncontrolled hypertension (high blood pressure).
• Avoid using in patients with active tuberculosis or a positive tuberculosis skin test.
• Not recommended for individuals with severe liver disease, as it can lead to worsening of liver function.
• Should not be used in patients with recent or active herpes simplex eye infections.
• Contraindicated during active or systemic viral, bacterial, or fungal infections unless directed by a physician.
• Avoid using Prednisolone syrup in patients with a history of hypersensitivity to any inactive ingredients present in the syrup formulation.

The side effects of Prednisolone 15mg Syrup/Suspension may include:

• Increased appetite and weight gain
• Stomach discomfort, indigestion, or nausea
• Nervousness, restlessness, or difficulty sleeping
• Skin bruising or thinning
• Acne or skin rashes
• Mood changes, including aggression, irritability, or depression
• Headache or dizziness
• Delayed wound healing

Following are the precautions and warnings for Prednisolone 15mg Syrup/Suspension:

• This medication should not be used in patients with systemic fungal infections or known hypersensitivity to Prednisolone or other corticosteroids.
• Long-term use may lead to adrenal suppression, so gradual withdrawal is essential to minimize the risk of adrenal crisis.
• May cause immunosuppression, increasing the risk of infections; exercise caution in patients with active infections.
• Monitor blood pressure, blood sugar levels, and bone density during prolonged treatment, as Prednisolone can cause hypertension, hyperglycemia, and osteoporosis.
• Avoid live vaccines in patients on high-dose Prednisolone therapy due to potential vaccine ineffectiveness or risk of infection.
• Children's growth and development should be monitored, as prolonged use may impact normal growth patterns.
• Elderly patients may be more susceptible to adverse effects; regular monitoring is essential.
• Always take as directed by your doctor and do not abruptly stop the medication to avoid withdrawal symptoms.

Following are the drug interactions for Prednisolone 15mg Syrup/Suspension:

• Co-administration with nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of gastrointestinal bleeding and ulceration.
• Use with warfarin or other anticoagulants can enhance the anticoagulant effect, requiring close monitoring of coagulation parameters.
• Caution is advised when using with diuretics, as it may reduce the excretion of sodium and water, leading to fluid retention.
• Combining with antidiabetic medications may increase blood glucose levels, necessitating adjustments in the antidiabetic regimen.
• It may decrease the effectiveness of live vaccines, so live vaccines should be avoided during treatment.
• Concomitant use with CYP3A4 inhibitors (e.g., ketoconazole, itraconazole) can increase prednisolone levels, potentially leading to enhanced side effects.
• Caution is warranted when using with CYP3A4 inducers (e.g., rifampin, phenytoin), as they may decrease prednisolone levels, reducing its therapeutic effect.

Following are the food interactions for Prednisolone 15mg Syrup/Suspension:

• Prednisolone can cause increased appetite, so it's important to maintain a balanced diet and avoid excessive consumption of high-calorie foods.
• High-sodium foods should be consumed in moderation as Prednisolone can lead to sodium and fluid retention.
• Foods rich in calcium and vitamin D are beneficial, as long-term use may affect bone health. Include dairy products, leafy greens, and fortified foods.
• Limit or avoid foods containing high levels of potassium, as Prednisolone can cause potassium retention. Examples include bananas, oranges, and potatoes.
• Maintain a healthy diet with plenty of fruits, vegetables, and whole grains to support overall health while on this medication.
• Avoid grapefruit and grapefruit juice as they can interfere with the metabolism of Prednisolone, potentially increasing its levels in the body.
• Alcohol should be consumed in moderation as it may increase the risk of gastrointestinal issues and interact with Prednisolone's effects.
• Always follow the dietary advice provided by your healthcare professional to ensure the medication's effectiveness and manage potential side effects.

Prednisolone 15mg Syrup/Suspension should be stored with care to ensure its effectiveness and safety. Keep the medication in a cool, dry area, preferably at room temperature, and shield it from direct sunlight and moisture. Maintain the original container's tight seal to prevent contamination. Avoid storage in bathrooms or near heat sources like stoves, as temperature fluctuations can impact the medicine's integrity. Regularly check the expiration date, and for proper disposal of unused or expired syrup, consult a pharmacist or healthcare professional. It is crucial to store the medication in a secure location, out of the reach of children, to prevent accidental consumption.

Following are the quick tips for Prednisolone 15mg Syrup/Suspension:

• Always follow your doctor's instructions for dosage and duration of treatment.
• Shake the bottle thoroughly before each use to ensure proper mixing.
• Administer the syrup with a measuring cup or oral syringe for accurate dosing.
• Take the medication as prescribed, even if you feel better, to ensure complete recovery.
• Avoid consuming grapefruit or grapefruit juice as it may affect the medicine's effectiveness.
• Inform your doctor about all medications you are taking to prevent potential interactions.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Regularly monitor your health and report any unusual symptoms to your healthcare provider.