Neurocoline (250mg/2ml, 1 Ampoule Injections

Citicoline, also known as cytidine 5'-diphosphocholine, has a multifaceted mechanism of action. It primarily acts as a prodrug for the synthesis of essential phospholipids in the brain, particularly phosphatidylcholine (PC) and sphingomyelin, which are vital components of neuronal membranes. Citicoline enhances the production of these phospholipids, supporting membrane integrity and fluidity. This action is believed to contribute to improved neuronal communication and overall brain function. Moreover, Citicoline exhibits neuroprotective properties by reducing oxidative stress, inhibiting the activation of cell death pathways, and promoting the synthesis of neurotransmitters, such as acetylcholine, dopamine, and norepinephrine. These effects collectively contribute to its therapeutic benefits in various neurological conditions.

Citicoline 250mg

Cholinergic, nootropic

Injection

The following are the uses of Citicoline 250mg injection:

• Used for improving cognitive function and enhancing memory, especially in elderly individuals with memory impairments.
• Used for treating neurological disorders such as Alzheimer's disease, dementia, and Parkinson's disease to slow down progression and manage symptoms.
• Used for supporting brain health after traumatic brain injuries, helping with recovery and reducing potential long-term effects.
• Used for addressing attention and behavioral issues in children with ADHD, improving focus and cognitive performance.
• Used for stroke rehabilitation, aiding in the recovery of brain function and reducing neurological deficits.
• Used for boosting mental energy and clarity, particularly in individuals experiencing mental fatigue or cognitive decline.
• Used for maintaining healthy brain cell membranes, promoting better communication between neurons.
• Used for individuals with glaucoma to potentially improve visual function and overall eye health.

In the case of an overdose of Citicoline 250mg injection, individuals may experience mild symptoms such as nausea, dizziness, and headaches. The severity of the overdose depends on the amount ingested. It is important to seek medical advice promptly if an overdose is suspected. Treatment involves managing the symptoms and providing supportive care. In rare cases, more serious side effects may occur, but these are typically associated with extremely high doses, far exceeding the recommended dosage.

In the case of a missed dose of Citicoline 250mg injection, it is important to administer the medication as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume the medication and adjust your dosing schedule.

To administer the Citicoline 250mg injection, clean the injection site, insert the needle at a 90-degree angle, inject the prescribed dose slowly, and then gently remove the needle while applying pressure with a sterile cotton ball to prevent bleeding.

Following are the conditions when Citicoline 250mg injection should not be administered:

• Must not be used in individuals with a known allergy or hypersensitivity to Citicoline or any of the excipients in the injection.
• Not suitable for individuals with severe kidney disease or impairment.
• Should not be used in cases of severe liver impairment or liver disease.
• Contraindicated in individuals with a history of seizures or epilepsy.
• Avoid in patients with a history of severe cardiovascular disease or those at risk of arrhythmias.
• Not recommended for children and adolescents under 18 years of age.
• Do not administer if there is any sign of infection or contamination at the injection site.
• Should not be used in individuals with a history of severe psychiatric disorders.

The side effects of Citicoline 250mg injection may include:

• Headache
• Nausea and vomiting
• Diarrhea
• Constipation
• Insomnia
• Dizziness
• Confusion
• Skin rashes or itching

Following are the precautions and warnings for Citicoline 250mg injection:

• Not recommended for individuals with a history of hypersensitivity or allergy to Citicoline or any of its excipients.
• Patients with severe renal or hepatic impairment should exercise caution and consult a doctor before use, as dosage adjustments may be necessary.
• Elderly patients should be monitored closely for potential side effects and dosage adjustments.
• This medication may cause mild gastrointestinal discomfort; patients with pre-existing gastrointestinal conditions should be cautious.
• Citicoline injection should be administered slowly and under medical supervision to avoid injection-related adverse events.
• Patients with a history of seizure disorders should be closely monitored, as Citicoline may lower the seizure threshold.
• Not recommended for pediatric use unless prescribed by a healthcare professional.

Following are the drug interactions for Citicoline 250mg injection:

• Citicoline may interact with cholinesterase inhibitors like donepezil, potentially causing excessive cholinergic effects. Close monitoring is advised.
• Anticoagulants such as heparin or warfarin may have their effects enhanced by Citicoline, increasing the risk of bleeding. Regular monitoring of coagulation parameters is recommended.
• The effectiveness of dopamine agonists like levodopa may be reduced by Citicoline, requiring dosage adjustments.
• Caution is advised when combining Citicoline with other central nervous system stimulants, as it may lead to additive effects and increased risk of seizures.
• Certain medications that affect blood pressure, such as antihypertensives, should be used cautiously with Citicoline as it may influence blood pressure.
• Citicoline may increase the risk of bleeding when used with antiplatelet drugs like aspirin or clopidogrel.
• The metabolism of Citicoline may be altered by medications that induce or inhibit liver enzymes, potentially affecting its efficacy.

Following are the food interactions for Citicoline 250mg injection:

• Avoid consuming grapefruit or grapefruit juice as it may alter the effectiveness of Citicoline, potentially leading to increased side effects.
• Alcohol intake should be limited or avoided as it can reduce the absorption of Citicoline and potentially impair cognitive function.
• High-fat meals may delay the absorption of Citicoline, so it is advisable to administer the injection at least 1-2 hours before or after a fatty meal.
• Caffeine intake should be monitored as it may counteract the cognitive-enhancing effects of Citicoline, potentially reducing its effectiveness.
• Avoid excessive sugar consumption as it can impact brain health and potentially interfere with Citicoline's benefits.
• Ensure adequate hydration to support the injection's administration and overall well-being.
• Maintain a balanced diet rich in nutrients to support brain health and optimize the effects of Citicoline.
• Consult healthcare professionals for personalized advice on diet and potential interactions with Citicoline.

Citicoline 250mg injection should be stored in a controlled environment, preferably in a cool and dry place with a temperature between 20-25°C (68-77°F). Protect the injection from direct sunlight, heat, and moisture to maintain its stability. Always keep the medication in its original packaging, ensuring the container is tightly sealed to prevent contamination. Regularly check the expiration date, and never use the injection beyond this date. When disposing of any unused or expired medication, do not flush it or pour it down the drain. Instead, follow local guidelines or consult a healthcare professional for safe disposal methods to protect the environment. Keep the injection out of the sight and reach of children to prevent accidental exposure.

Following are the quick tips for Citicoline 250mg injection:

• Ensure the injection is administered by a trained healthcare professional.
• Verify the dosage and expiration date before injection.
• Inform your doctor about all medications you are taking.
• Relax and breathe comfortably during the injection process.
• Report any discomfort, redness, or swelling at the injection site to your doctor.
• Maintain hydration before and after the injection.
• Do not reuse needles or syringes; dispose of them safely.
• Store the injection as directed on the package.