Neurolith SR (400mg) 100 Tablets

Lithium Carbonate 400mg Tablet primarily exerts its therapeutic effects by inhibiting the enzyme glycogen synthase kinase-3 (GSK-3). This inhibition leads to an increase in the production of certain neurotransmitters in the brain, particularly serotonin and norepinephrine. Lithium modulates the signaling pathways of these neurotransmitters, resulting in enhanced mood stabilization and reduced manic symptoms. It is believed that lithium stabilizes neuronal membranes, influencing sodium transport and modulating intracellular signaling cascades, which ultimately contribute to its mood-stabilizing properties. Additionally, lithium may impact gene expression and cellular processes involved in neuronal plasticity and neuroprotection, further contributing to its mechanism of action in treating bipolar disorder.

Lithium Carbonate 400mg

Lithium Carbonate is a mood stabilizer.

Tablet

The following are the uses of Lithium Carbonate 400mg Tablet:

• Used for treating manic or depressive episodes in bipolar disorder.
• Used to stabilize mood and prevent extreme mood swings.
• Used to treat symptoms of mania, such as hyperactivity and impulsivity.
• Used for long-term maintenance to reduce the frequency of mood episodes.
• Used to enhance mood stabilization when combined with other medications.
• Used to improve overall functioning and quality of life in bipolar patients.
• Used to reduce suicidal thoughts and aggressive behavior.

To be taken as per doctor's prescription

In the case of an overdose of Lithium Carbonate 400mg Tablets, symptoms may include nausea, vomiting, diarrhea, and dizziness. Severe cases can lead to kidney dysfunction, seizures, and cardiac arrhythmias. Prompt medical intervention is necessary, including gastric lavage and supportive care. Treatment focuses on stabilizing vital signs, maintaining fluid balance, and monitoring renal function. Close observation and management of potential complications are crucial in these situations.

In the case of a missed dose of Lithium Carbonate 400mg Tablet, it is generally recommended to take the missed dose as soon as you remember, but only if the next scheduled dose is not too close. If it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Avoid taking a double dose to make up for a missed one, as this may increase the risk of side effects. It is important to maintain a consistent medication routine, but if you miss a dose, consult your healthcare provider for specific advice on how to handle the situation safely.

To take Lithium Carbonate 400mg Tablets, swallow the tablet whole with a full glass of water, preferably with or after a meal, as directed by your healthcare professional, typically once or twice daily, following the prescribed dosage and treatment duration to manage your condition effectively.

Here are the circumstances when Lithium Carbonate 400mg Tablet should not be taken:

• Not suitable for individuals with a known allergy or hypersensitivity to lithium or any of the tablet's components.
• Contraindicated in patients with significant renal (kidney) impairment or end-stage renal disease.
• Should not be used in individuals with severe cardiovascular conditions, such as uncontrolled hypertension or recent myocardial infarction.
• Not recommended for patients with severe dehydration or electrolyte imbalances, especially sodium depletion.
• Contraindicated in patients with untreated hypothyroidism or hyperthyroidism.
• Should be avoided in individuals with severe gastrointestinal disorders, such as active peptic ulcer or severe diarrhea.
• Not suitable for patients with severe neurological disorders, including severe tremors or Parkinson's disease.
• Should not be used during pregnancy or while breastfeeding, as lithium may cause harm to the fetus or infant.
• Contraindicated in patients with a history of lithium-induced toxicity or severe side effects.

The side effects of Lithium Carbonate 400mg Tablet may include:

• Increased thirst and frequent urination
• Nausea and vomiting
• Diarrhea
• Tremors or shaking
• Dizziness or lightheadedness
• Fatigue and weakness
• Confusion or difficulty concentrating
• Weight gain

Following are the precautions and warnings for Lithium Carbonate 400mg Tablet:

• Patients with a history of kidney or heart disease should be closely monitored as Lithium Carbonate can affect kidney and heart function.
• Regular blood tests are necessary to monitor Lithium levels, kidney function, and thyroid function while taking this medication.
• Patients should maintain adequate fluid intake and avoid dehydration, as this can lead to increased Lithium levels.
• Caution is advised for individuals with a history of seizures, as Lithium Carbonate may lower the seizure threshold.
• Elderly patients may be more sensitive to the effects and side effects of this medication.
• Lithium Carbonate can interact with numerous medications; patients should inform their doctor of all medications they are taking.
• It is important to avoid sudden changes in diet, especially salt intake, as this can affect Lithium levels.

Following are the drug interactions for Lithium Carbonate 400mg Tablet:

• Lithium can interact with diuretics (e.g., thiazide diuretics, loop diuretics), leading to increased lithium levels and potential toxicity. Close monitoring is necessary.
• The use of nonsteroidal anti-inflammatory drugs (NSAIDs) with lithium may decrease lithium excretion, resulting in higher lithium levels and increased risk of side effects.
• Angiotensin-converting enzyme (ACE) inhibitors can reduce lithium elimination, leading to increased lithium levels and potential toxicity. Regular monitoring is required.
• Lithium may enhance the effects of neuroleptic medications, increasing the risk of neuroleptic malignant syndrome, a rare but serious condition.
• Antidepressants like selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants can increase lithium levels, requiring dose adjustments.
• Methyldopa, an antihypertensive medication, may elevate lithium concentrations, necessitating careful monitoring.
• Calcium channel blockers can interact with lithium, potentially leading to lithium toxicity or reduced effectiveness.

Following are the food interactions for Lithium Carbonate 400mg Tablet:

• Avoid excessive consumption of salt or salty foods as they can decrease the elimination of lithium, potentially leading to increased lithium levels in the body.
• Caffeine intake should be limited as it may increase lithium levels and the risk of side effects, especially those related to the nervous system.
• Avoid alcohol as it can lead to increased lithium levels and increase the risk of side effects, including dizziness and impaired coordination.
• Stay hydrated and maintain a consistent fluid intake to prevent dehydration, which can affect lithium concentrations.
• Avoid or limit smoking as nicotine can interact with lithium, potentially altering its effectiveness.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of lithium, leading to unpredictable changes in blood levels.
• Maintain a balanced diet, as sudden changes in dietary habits can impact lithium absorption and excretion.
• Consult your healthcare provider for specific dietary recommendations and to report any unusual symptoms or changes while taking Lithium Carbonate.

Lithium Carbonate 400mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or designated storage area. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to moisture. Avoid storing them in the bathroom or kitchen, as these areas can be prone to temperature fluctuations and humidity. It is crucial not to dispose of the tablets by flushing them down the toilet or sink; instead, follow local guidelines for medication disposal or consult your pharmacist for safe disposal practices. Always keep medications out of the sight and reach of children to prevent accidental consumption, and ensure the storage area is locked or inaccessible to them. Regularly check the expiration date on the packaging and properly discard any expired tablets according to recommended procedures.

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Following are the quick tips for Lithium Carbonate 400mg Tablet:

• Take the tablet as directed by your doctor, usually once or twice daily.
• Swallow the tablet whole with a full glass of water, preferably at the same time each day.
• Do not crush, chew, or break the tablet, as it may affect its effectiveness.
• Maintain a consistent lithium level by taking the medication regularly and avoiding missed doses.
• Get your lithium levels checked regularly as advised by your doctor.
• Inform your doctor about all medications you are taking to prevent potential drug interactions.
• Store the tablets in a cool, dry place away from direct sunlight and moisture.