Nevramin 300 Tablets

Thiamine Hydrochloride, also known as Thiamine HCl, is a water-soluble vitamin that plays a crucial role in various physiological processes. Its primary mechanism of action revolves around its function as a coenzyme, particularly as thiamine pyrophosphate (TPP). TPP is an essential cofactor for several enzymes involved in carbohydrate metabolism, such as pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase. These enzymes are critical in the citric acid cycle (TCA cycle) and the production of ATP, the body's main energy source. Thiamine HCl facilitates the conversion of carbohydrates into energy by aiding in the breakdown of pyruvate and alpha-ketoglutarate, allowing for the generation of cellular energy and supporting overall metabolic functions.

Vitamin B1 (Thiamine)

Tablet

The following are the uses of Thiamine Hcl 1 Tablet:

• Used for preventing and treating thiamine (vitamin B1) deficiency.
• Used for treating a specific type of brain dysfunction caused by thiamine deficiency.
• Used for enhancing learning capacity and cognitive function.
• Used for improving energy metabolism and overall health in people with fatigue or weakness.
• Used for supporting the nervous system and promoting healthy nerve function.
• Used for maintaining a healthy cardiovascular system and proper heart function.
• Used for managing symptoms related to alcohol withdrawal and supporting recovery.

In the case of an overdose of Thiamine Hcl 1 Tablet, individuals may experience symptoms such as restlessness, rapid breathing, and nausea. It is important to remain calm and seek medical advice promptly. Contact a healthcare professional or poison control center for guidance on managing the overdose. They will provide specific instructions based on the individual's condition and the amount of medication ingested.

In the case of a missed dose of Thiamine Hcl 1 Tablet, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one, as this may increase the risk of side effects. Consult your healthcare provider if you frequently miss doses or are unsure about how to manage missed doses.

To take Thiamine Hcl 1 Tablet, place the tablet on your tongue and swallow it with a glass of water, preferably at the same time each day, as directed by your healthcare provider.

Here are the conditions or situations when Thiamine Hcl 1 Tablet should not be taken:

• Avoid using if you have a known allergy or sensitivity to Thiamine (Vitamin B1) or any other B-complex vitamins.
• Not suitable for patients with a history of hemodialysis or peritoneal dialysis.
• Should not be used in individuals with thiamine hypersensitivity or hyperthyroidism.
• Contraindicated in those with severe kidney impairment or kidney failure.
• Avoid using if you have an overactive thyroid (thyrotoxicosis).
• Not recommended for individuals with severe liver disease or liver failure.

The side effects of Thiamine Hcl 1 Tablet may include:

• Skin rash or itching
• Stomach upset or pain
• Nausea and vomiting
• Diarrhea
• Dizziness
• Headache
• Fatigue or weakness
• Changes in heart rate

Following are the precautions and warnings for Thiamine Hcl 1 Tablet:

• Thiamine Hcl should not be taken if you have a known allergy to thiamine or any other B-vitamin.
• This medication may cause an allergic reaction, and medical attention should be sought immediately if symptoms such as rash, itching, swelling, or difficulty breathing occur.
• Patients with a history of kidney disease should use Thiamine Hcl with caution and under medical supervision.
• Alcohol consumption should be avoided as it may reduce the effectiveness of the medication.
• Do not exceed the recommended dosage, as high doses of Thiamine Hcl may cause adverse effects.
• Pregnant and breastfeeding women should consult their doctor before taking Thiamine Hcl, as it may pass into breast milk.
• Keep this medication out of the reach of children and pets.

Following are the drug interactions for Thiamine Hcl 1 Tablet:

• Thiamine may interact with alcohol, as it can reduce the absorption of thiamine, potentially leading to decreased effectiveness.
• Diuretics, such as furosemide, can increase the excretion of thiamine, requiring closer monitoring.
• Antacids containing aluminum or magnesium may decrease the absorption of thiamine when taken simultaneously.
• Digoxin levels may be affected by thiamine supplementation, requiring monitoring of digoxin concentrations.
• Thiamine can enhance the effectiveness of carbamazepine, an anticonvulsant, and may require dosage adjustments.
• Phenytoin, another anticonvulsant, may have decreased metabolism when taken with thiamine, leading to increased phenytoin levels.
• Certain chemotherapy drugs, like doxorubicin, may have enhanced cardiotoxicity when used with high-dose thiamine.
• Thiamine supplementation may be necessary when taking medications that deplete thiamine levels, such as high-dose loop diuretics or long-term dialysis.

Following are the food interactions for Thiamine Hcl Tablet:

• Thiamine deficiency can be prevented by including thiamine-rich foods like whole grains, legumes, nuts, seeds, and pork in your diet.
• Consuming foods high in thiamine along with the supplement can help restore thiamine levels in the body.
• Alcohol consumption should be limited or avoided as it can interfere with thiamine absorption and increase the risk of deficiency, especially in heavy drinkers.
• Avoid excessive consumption of tea and coffee as they may contain tannins that can reduce thiamine absorption.
• Avoid raw fish and shellfish as they may contain thiaminase, an enzyme that breaks down thiamine, leading to reduced absorption.
• Cooked and processed foods may have lower thiamine content, so ensure a balanced diet with fresh produce.
• Some food preservatives and additives might interfere with thiamine absorption, so opt for fresh, whole foods when possible.
• Maintaining a balanced diet with a variety of foods ensures adequate thiamine intake and minimizes the need for supplementation.

Thiamine Hcl 1 Tablet should be stored in a cool and dry area, ideally at room temperature, ensuring protection from direct sunlight and moisture. Keep the tablets in their original packaging, tightly sealed, to maintain their integrity and prevent contamination. Avoid exposure to heat sources like ovens or radiators, as extreme temperatures can impact the medication's effectiveness. Dispose of any unused or expired tablets responsibly; do not flush them or pour them down the drain. Consult a pharmacist or healthcare professional for guidance on proper disposal methods. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Thiamine Hcl 1 Tablet:

• Consult your healthcare provider for the right dosage and duration of treatment.
• Take the tablet as directed, ensuring you follow the prescribed dosage.
• Thiamine Hcl can be taken with or without food, but taking it with meals may reduce stomach irritation.
• If you experience difficulty swallowing tablets, ask your pharmacist about alternative forms.
• Do not crush or chew the tablet unless advised by your doctor.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.
• Regularly monitor your vitamin B1 levels while taking Thiamine Hcl to ensure effectiveness.
• Inform your doctor about all medications you are taking to avoid potential interactions.