Nexa (40mg) 14 Sachets

Esomeprazole, the active ingredient in the 40mg sachet formulation, acts as a potent proton pump inhibitor. It specifically targets the gastric proton pump, also known as the hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), which is responsible for acid secretion in the stomach. Esomeprazole irreversibly binds to and inhibits this pump, leading to a significant reduction in gastric acid secretion. By inhibiting the proton pump, esomeprazole effectively suppresses the production of gastric acid, creating a more alkaline environment in the stomach, which helps in the management of conditions where acid reduction is desired.

Esomeprazole 40mg

Proton pump inhibitor.

powder

The following are the uses of Esomeprazole 40mg Sachet:

• Used for treating gastroesophageal reflux disease (GERD) by reducing stomach acid production.
• Used to heal erosive esophagitis caused by acid reflux.
• Used in managing symptoms of non-cancerous stomach and throat ulcers.
• Used to treat conditions where the stomach produces too much acid, like Zollinger-Ellison syndrome.
• Used as a preventative measure for acid-related damage in specific medical cases.
• Used to aid in the eradication of Helicobacter pylori infections when combined with antibiotics.
• Used to provide relief from persistent heartburn and acid regurgitation.

In the case of an overdose of Esomeprazole 40mg Sachets, symptoms may include blurred vision, confusion, drowsiness, and an irregular heartbeat. It is important to seek medical advice immediately if you suspect an overdose. Prompt treatment can help alleviate potential adverse effects, which may include severe stomach pain, persistent nausea, and diarrhea. The healthcare provider may induce vomiting or administer activated charcoal to prevent further absorption of the medication.

In the case of a missed dose of Esomeprazole 40mg Sachet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen. Consult your healthcare provider if you have any concerns or questions about missed doses.

To take Esomeprazole 40mg Sachet, empty the contents of the sachet into a glass of water, stir well until completely dissolved, and drink the mixture, preferably in the morning, at least one hour before a meal, as directed by your healthcare professional.

Following are the conditions/situations when Esomeprazole 40mg Sachet should not be taken:

• Do not take if you are allergic to Esomeprazole or other proton pump inhibitors (PPIs).
• Avoid using this medication if you have severe liver problems.
• Do not use Esomeprazole if you have a rare metabolic disorder called hereditary fructose intolerance.
• Contraindicated in patients with low magnesium levels in the blood (hypomagnesemia).
• Should not be taken if you are currently taking a medicine that contains rilpivirine.
• Do not use if you have an abnormal growth in the stomach (gastric carcinoid tumor).

The side effects of Esomeprazole 40mg Sachet may include:

• Headache
• Dizziness
• Diarrhea
• Nausea and vomiting
• Abdominal pain
• Skin rash or itching
• Fatigue and weakness
• Joint pain

Following are the precautions and warnings for Esomeprazole 40mg Sachet:

• Do not take Esomeprazole if you are allergic to any of its ingredients or other proton pump inhibitors.
• Inform your doctor about any liver or kidney problems as dose adjustments may be necessary.
• Long-term use may lead to vitamin B12 deficiency, so regular monitoring is advised.
• This medication may cause bone fractures with long-term use, especially in high doses or for extended periods.
• Patients with osteoporosis or those at risk should exercise caution and consult their doctor.
• Elderly patients may have an increased risk of hip, wrist, and spine fractures with prolonged use.
• Esomeprazole may interact with other medicines, so inform your doctor about all medications you are taking.

Following are the drug interactions for Esomeprazole 40mg Sachet:

• Decreased absorption of drugs that require a higher gastric pH for absorption, such as ketoconazole, ampicillin esters, and iron salts.
• May reduce the effectiveness of clopidogrel when used concurrently.
• Can increase plasma concentrations of drugs metabolized by CYP2C19, including diazepam, warfarin, and phenytoin, requiring monitoring and dose adjustments.
• Co-administration with digoxin may slightly increase digoxin levels, warranting monitoring.
• Reduced absorption of erlotinib when taken with esomeprazole.
• May increase plasma concentrations of cilostazol, a CYP2C19 and CYP3A4 substrate, requiring dose adjustments.
• Impaired metabolism of escitalopram, a CYP2C19 substrate, leading to increased plasma concentrations.
• Potential interaction with methotrexate, requiring temporary withdrawal of proton pump inhibitors before methotrexate administration.

Following are the food interactions for Esomeprazole 40mg Sachet:

• Esomeprazole should be taken at least 1 hour before meals. Avoid consuming it with food as certain foods can interfere with its absorption.
• Avoid caffeine while on Esomeprazole treatment, as it can increase stomach acid production and reduce the medication's effectiveness.
• Grapefruit and grapefruit juice are to be avoided as they can alter the metabolism of Esomeprazole, leading to increased levels in the body and potential side effects.
• Alcohol intake should be limited as it can irritate the stomach and decrease the healing process, especially if you have a history of gastrointestinal issues.
• Spicy foods may trigger acid reflux symptoms and should be consumed in moderation or avoided to ensure the medication's effectiveness.
• Chocolate contains substances that can relax the lower esophageal sphincter, potentially causing reflux, so it's best to limit its consumption.
• Fried and fatty foods can slow down the emptying of the stomach and trigger reflux symptoms, so they should be consumed sparingly.
• Avoid carbonated drinks as they can increase stomach pressure and potentially cause acid reflux, reducing the medication's efficacy.

Esomeprazole 40mg Sachet should be stored in a cool and dry place, preferably at room temperature, ensuring it remains protected from direct sunlight, moisture, and heat. The sachets should be kept tightly sealed within their original packaging to maintain their integrity and prevent contamination. It is crucial to be mindful of the expiration date, and any unused or expired medication should be disposed of responsibly. Avoid flushing or pouring the contents down the drain; instead, consult a pharmacist or healthcare professional for appropriate disposal guidelines. Additionally, it is imperative to store the medication in a secure location, out of the reach of children, to prevent accidental consumption.

Following are the quick tips for Esomeprazole 40mg Sachet:

• Mix the sachet contents with a glass of water and drink the mixture, ensuring complete consumption.
• Take the medication once daily, preferably in the morning, 30 minutes before breakfast.
• Avoid crushing or chewing the granules; swallow them whole for optimal effectiveness.
• Maintain consistency by taking your dose at the same time each day.
• Do not take this medication with other medications without consulting your doctor.
• Inform your healthcare provider if you have liver or kidney problems before taking this medicine.
• Store the sachets in a cool, dry place, away from direct sunlight and moisture.