Nutrifactor Nuroton 30 Tablets

Niacin (also known as nicotinic acid) and Pyridoxine (vitamin B6) work together in this tablet to provide a synergistic effect on various physiological processes. Niacin primarily acts as a vasodilator by binding to and activating the G-protein-coupled receptor, GPR109A, found on adipocytes and immune cells. This activation leads to increased cyclic AMP levels, resulting in smooth muscle relaxation and improved blood flow. Additionally, niacin plays a role in reducing triglyceride levels and increasing HDL cholesterol. On the other hand, Pyridoxine is involved in numerous metabolic reactions as a coenzyme, particularly in the metabolism of amino acids and neurotransmitters. It helps in the conversion of tryptophan to niacin, further supporting the body's niacin levels. Pyridoxine is also essential for the synthesis of hemoglobin and proper brain development. This combination of mechanisms contributes to the overall therapeutic effects of the Niacin, Pyridoxine Tablet.

Vitamin B Complex.

Tablet

The following are the uses of Niacin, Pyridoxine Tablet:

• Used for treating and preventing vitamin B3 (niacin) deficiency, which can lead to a condition called pellagra.
• Used for improving cholesterol levels and reducing the risk of heart disease.
• Used for supporting brain function and cognitive health, as it plays a role in neurotransmitter synthesis.
• Used for managing symptoms of arthritis, such as joint pain and stiffness.
• Used for enhancing energy production in the body by aiding in the conversion of food into energy.
• Used for promoting healthy skin, as it supports skin hydration and reduces inflammation.
• Used for supporting the nervous system and maintaining its proper functioning.
• Used for improving overall well-being and addressing certain nutritional deficiencies.

In the case of an overdose of Niacin or Pyridoxine Tablets, the symptoms may vary. Excessive consumption of Niacin can lead to skin flushing, dizziness, and liver issues. On the other hand, an overdose of Pyridoxine might result in sensory changes, such as numbness or tingling in the hands and feet, as well as potential gastrointestinal distress. Prompt medical consultation is advisable if an overdose is suspected to ensure appropriate treatment and management.

In the case of a missed dose of Niacin and Pyridoxine Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, consult your healthcare professional for advice on how to safely resume your medication.

To take the Niacin and Pyridoxine tablet, swallow it whole with a full glass of water, preferably during a meal or as directed by your healthcare professional, following the prescribed dosage and schedule provided.

Following are the conditions/situations when Niacin, Pyridoxine Tablet should not be used:

• Must not be used in patients with a known allergy or hypersensitivity to niacin (vitamin B3), pyridoxine (vitamin B6), or any of the other ingredients in the tablet.
• Not suitable for individuals with a history of liver disease or active liver disorders, as it may cause further liver damage.
• Should be avoided in patients with a history of gout, as it can increase uric acid levels.
• Contraindicated in patients with active peptic ulcer disease or bleeding disorders, as it may worsen these conditions.
• Not recommended for individuals with a history of heart disease or recent heart attack, as high doses of niacin may affect cardiovascular health.
• Should not be used in patients with severe kidney disease, as it can affect kidney function.
• Avoid using this medication if you have a rare inherited condition called Hartnup disease.
• Do not take if you have optic neuropathy, a type of nerve damage that affects vision.

The side effects of Niacin, Pyridoxine Tablet may include:

• Skin flushing
• Itching or rash
• Nausea and vomiting
• Stomach pain
• Diarrhea
• Headache
• Dizziness
• Increased liver enzymes (liver function tests)

Following are the precautions and warnings for Niacin, Pyridoxine Tablet:

• Not suitable for individuals with a known allergy to niacin or pyridoxine.
• Patients with a history of liver or kidney disease should use with caution, as these conditions may affect the metabolism and excretion of the medication.
• May cause flushing, itching, or gastrointestinal disturbances; these effects are usually mild and temporary.
• Niacin may increase blood sugar levels, so diabetic patients should monitor their glucose levels regularly.
• Patients with a history of gout should exercise caution, as niacin may elevate uric acid levels.
• Can cause dizziness or lightheadedness, so caution is advised when performing activities that require alertness.
• The tablet may interact with other medications, including cholesterol-lowering drugs and blood thinners, so consult a healthcare professional before combining with other treatments.

Following are the drug interactions for Niacin, Pyridoxine Tablet:

• Alcohol consumption may increase the risk of liver toxicity when combined with niacin.
• Niacin can interact with statins, increasing the risk of muscle-related side effects such as myopathy and rhabdomyolysis.
• Pyridoxine (vitamin B6) may reduce the effectiveness of levodopa in Parkinson's disease.
• Anticonvulsant medications like phenytoin and carbamazepine may have decreased efficacy when taken with pyridoxine.
• Insulin or oral hypoglycemic drugs may need adjustment as niacin can affect blood glucose levels.
• Niacin may increase the risk of bleeding when taken with anticoagulants or antiplatelet drugs.
• Certain medications metabolized by the liver may have altered effects when combined with niacin, including some antibiotics and antifungals.

Following are the food interactions for Niacin, Pyridoxine Tablet:

• Avoid excessive alcohol consumption while taking this medication, as alcohol may interfere with the absorption and effectiveness of the vitamins.
• Grapefruit and grapefruit juice should be consumed with caution as they can potentially interact with Niacin, affecting its metabolism and increasing the risk of side effects.
• Vitamin B-rich foods like whole grains, meat, fish, eggs, and dairy products can enhance the absorption of Niacin and Pyridoxine, ensuring better utilization of these vitamins.
• Avoid high-fat meals as they might interfere with the absorption of Niacin, particularly the extended-release forms.
• Limit the intake of foods rich in tyramine (aged cheeses, cured meats, fermented foods) as Pyridoxine may lower the body's ability to break down tyramine, leading to high blood pressure.
• Caffeine-rich foods and beverages may decrease the absorption of Pyridoxine and should be consumed in moderation.
• Foods with high levels of oxalic acid (spinach, rhubarb, beets) can interfere with the absorption of Pyridoxine, so consider spacing out their consumption.
• Maintain a balanced diet to ensure the optimal utilization of these vitamins and minimize potential interactions.

Niacin and Pyridoxine Tablets should be stored in a cool, dry area, ideally at room temperature between 68°F and 77°F (20°C and 25°C). Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to moisture. It's crucial to avoid storing them in the bathroom or kitchen, as these areas can have high humidity and temperature fluctuations. Always check the expiration date before use, and if the tablets are past their prime, do not use them. For proper disposal, do not flush them down the toilet or pour them into a drain; instead, consult your pharmacist or local waste disposal company for safe disposal methods, ensuring that the medication is kept out of the reach of children and pets to prevent accidental consumption.

Following are the quick tips for Niacin, Pyridoxine Tablet:

• Take the tablet as directed by your doctor, typically with meals to enhance absorption.
• Swallow the tablet whole without crushing or chewing for best results.
• Maintain a consistent dosing schedule to ensure stable blood levels.
• If you experience mild flushing, it's a normal side effect and usually subsides with continued use.
• Avoid taking antacids or indigestion remedies within 2 hours of taking the tablet.
• Inform your doctor about all medications you're taking to prevent potential interactions.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.