NIACIN 500MG CAP (60S) (S/V)

Niacin, also known as nicotinic acid, primarily exerts its effects through its active metabolite, nicotinamide adenine dinucleotide (NAD). NAD is a coenzyme involved in numerous biochemical reactions in the body. The mechanism of action of niacin is complex and involves multiple pathways. It primarily acts by binding to and activating the G protein-coupled receptor, GPR109A, which is expressed on adipocytes and immune cells. This activation leads to the inhibition of lipolysis in adipose tissue, resulting in reduced levels of free fatty acids and a decrease in the synthesis of very-low-density lipoprotein (VLDL) in the liver. Consequently, niacin increases high-density lipoprotein (HDL) cholesterol levels and reduces low-density lipoprotein (LDL) cholesterol and triglyceride levels, thereby improving the lipid profile. Additionally, niacin may have anti-inflammatory effects by modulating immune cell function and reducing the production of pro-inflammatory cytokines.

Vitamin B3 (Niacin)

Capsule

The following are the uses of Niacin Capsule:

• Used for reducing bad cholesterol and raising good cholesterol levels.
• Used for treating and preventing vitamin B3 deficiency.
• Used for supporting heart health and reducing the risk of cardiovascular issues.
• Used for improving circulation and reducing inflammation.
• Used for managing skin conditions and promoting healthy skin.
• Used for enhancing brain function and cognitive abilities.
• Used for supporting energy metabolism and cellular health.
• Used for aiding in the treatment of certain skin conditions like acne.

In the case of an overdose of Niacin Capsules, individuals may experience symptoms such as flushing, itching, nausea, and vomiting. More severe cases can lead to liver damage, elevated blood sugar levels, and gastrointestinal bleeding. It is crucial to contact a healthcare professional or poison control center immediately for guidance and to determine the appropriate course of action. Prompt medical intervention can help manage symptoms and prevent potential complications associated with excessive niacin intake.

In the case of a missed dose of Niacin Capsule, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare provider for guidance on how to safely resume your medication and adjust your dosing schedule. It is advisable to set reminders or use a pill organizer to help you stay on track with your medication regimen.

To take the Niacin Capsule, swallow it whole with a full glass of water, preferably during a meal or as directed by your healthcare professional, following the dosage instructions provided.

Here are the situations or conditions when Niacin Capsule should not be taken:

• Avoid using if you have a known allergy to niacin or any similar medications.
• Not suitable for individuals with severe liver disease or active liver damage.
• Should not be used if you have a recent history of heart attack or acute gout.
• Contraindicated in individuals with bleeding disorders or active stomach ulcer.
• Avoid using if you have uncontrolled or severe diabetes.
• Not recommended for individuals with kidney disease or kidney failure.
• Do not take if you have a history of gastrointestinal surgery or narrowing of the digestive tract.
• Should not be used in individuals with a history of stroke or blood vessel disorders.
• Avoid using if you have a history of eye surgery or increased eye pressure.

The side effects of Niacin Capsule may include:

• Skin flushing (warmth, redness, itching, or tingling)
• Upset stomach, nausea, or vomiting
• Diarrhea
• Dizziness
• Headache
• Macular edema (swelling of the retina in the eye)
• Liver problems
• Increased blood sugar levels

Here are the precautions and warnings for Niacin Capsule:

• Not suitable for individuals with a known allergy or sensitivity to niacin or related substances.
• Patients with liver or kidney disease should use with caution, as niacin may affect these organs.
• May cause flushing, itching, or gastrointestinal discomfort, which are generally mild and temporary.
• Prolonged use of high doses may lead to liver damage; regular monitoring is recommended.
• Blood tests may be required to monitor liver function and blood sugar levels during treatment.
• Diabetic patients should be cautious as niacin may affect blood sugar control.
• Consult a healthcare professional before use if you have a history of gout, stomach ulcers, or heart disease.

Following are the drug interactions for Niacin Capsule:

• Statins, Increased risk of myopathy and rhabdomyolysis when used with statins; monitor for muscle symptoms and check creatine kinase.
• Anticoagulants, Niacin may enhance the anticoagulant effect, requiring close monitoring of coagulation parameters.
• Anti-diabetic medications, Niacin can alter blood glucose levels, possibly requiring adjustments in anti-diabetic drugs.
• Anti-hypertensives, May have additive effects on blood pressure, requiring careful monitoring.
• Aspirin, Niacin may increase the risk of bleeding when taken with aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs).
• Alcohol, Use with alcohol may increase the risk of liver toxicity.
• Certain anticonvulsants, Niacin can affect the metabolism of some anticonvulsants, requiring dosage adjustments.

Following are the food interactions to be aware of when taking Niacin Capsules:

• Avoid excessive alcohol consumption as it may increase the risk of liver problems and may also intensify the flushing side effect associated with Niacin.
• Consuming hot beverages or spicy foods might exacerbate the flushing reaction, so it's advisable to avoid or minimize their intake.
• Grapefruit and grapefruit juice should be consumed with caution as they can interfere with the breakdown of Niacin, leading to higher levels in the blood and potentially increasing side effects.
• Niacin can interact with high-fat meals, leading to increased absorption and potentially higher peak levels in the blood, which may increase the risk of side effects.
• Dairy products, such as milk or yogurt, can bind to Niacin and reduce its absorption. Consuming these together might decrease the effectiveness of the medication.
• Vitamin B3-rich foods like peanuts, mushrooms, and whole grains may reduce the effectiveness of Niacin supplements, as the body may already have sufficient levels from dietary sources.
• Green tea and green tea extracts might interact with Niacin, potentially increasing its blood-thinning effects and the risk of bleeding.

Niacin capsules should be stored in a cool, dry place, preferably at room temperature, ensuring protection from light and moisture. The original container should be tightly sealed to maintain its integrity and prevent exposure to contaminants. It is crucial not to store the capsules in the bathroom or near heat-emitting appliances to maintain their effectiveness. Always check the expiration date, and for proper disposal, consult a pharmacist or healthcare professional rather than discarding them in toilets or drains. Keep the medication securely stored away from children to prevent accidental consumption.

Following are the quick tips for Niacin Capsule:

• Consult your healthcare provider for the right dosage and duration of treatment.
• Swallow the capsule whole with a full glass of water, preferably after a meal.
• Do not break, crush or chew the capsule to avoid a bitter taste and ensure proper absorption.
• Avoid taking antacids or indigestion remedies within 2 hours of taking the capsule.
• Inform your doctor about all medications you are taking to prevent potential drug interactions.
• Niacin may cause a temporary flushing reaction, which is usually harmless but can be uncomfortable.
• If you experience severe flushing, headache, dizziness or other unusual symptoms, contact your doctor immediately.
• Store the capsules in a cool, dry place away from direct sunlight and moisture.