NIACIN TAB (MEDI GREEN) 30S

Niacin, also known as nicotinic acid, primarily exerts its therapeutic effects through its actions on lipid metabolism. The mechanism of action involves several processes. Niacin is a precursor to nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which are essential coenzymes in various metabolic pathways. When administered, niacin binds to and activates the G-protein-coupled receptor known as the niacin receptor 1 (NIACR1) or GPR109A, primarily found on adipocytes. This activation leads to the inhibition of lipolysis, resulting in decreased free fatty acid levels in the blood. Consequently, decreased hepatic fatty acid uptake stimulates the upregulation of LDL receptors, promoting increased LDL-C clearance and reduced plasma LDL-C levels. Additionally, niacin enhances the hepatic synthesis of apolipoprotein A-I, the primary protein component of HDL, leading to increased HDL-C levels. This dual effect on lipid metabolism contributes to the overall improvement in lipid profiles observed with niacin therapy.

Vitamin B3.

Tablet

The following are the uses of Niacin Tablet:

• Used for treating and preventing niacin deficiency, commonly known as pellagra.
• Used for improving cholesterol levels and reducing the risk of heart disease.
• Used for supporting brain function and enhancing cognitive abilities.
• Used for managing symptoms of arthritis and reducing joint pain and stiffness.
• Used for supporting skin health and treating certain skin conditions.
• Used for boosting energy production in cells and improving overall metabolism.
• Used for its potential role in managing type 1 diabetes and improving blood sugar control.
• Used for its anti-inflammatory properties, which may aid in various health conditions.

In the case of an overdose of Niacin Tablets, it is important to remain calm and take swift action. Contact your healthcare provider or local poison control center for guidance. They will provide specific instructions based on the amount ingested and the patient's medical history. Prompt medical assessment is essential to determine the appropriate treatment, which may include monitoring vital signs, providing supportive care, and addressing any potential complications related to the overdose.

In the case of a missed dose of Niacin Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for advice on how to safely resume your medication. It is generally recommended to take the missed dose within a 24-hour window to maintain the medication's effectiveness.

To take the Niacin Tablet, swallow the tablet whole with a full glass of water, preferably after a meal, following the dosage instructions provided by your healthcare professional.

Following are the conditions when Niacin Tablet should not be used:

• Avoid if you have a history of liver disease, stomach ulcers, gout, or diabetes.
• Do not take if you are allergic to any of its ingredients.
• Contraindicated in individuals with severe liver damage or severe kidney disease.
• Not suitable for individuals with a history of heart attack or stroke.
• Avoid if you have a history of bleeding disorders or if you are taking blood-thinning medications.
• Should not be used in individuals with untreated or unstable angles-closure glaucoma.
• Not recommended for individuals with a history of gastrointestinal surgery or disorders.
• Do not take if you have a rare hereditary problem of galactose intolerance, severe lactase deficiency, or glucose-galactose malabsorption.

The side effects of Niacin Tablet may include:

• Flushing or redness of the skin
• Itching or rash
• Nausea and vomiting
• Stomach pain or cramps
• Diarrhea
• Dizziness or lightheadedness
• Headache
• Increased heart rate or palpitations

Following are the precautions and warnings for Niacin Tablet:

• Not suitable for individuals with a known allergy to niacin or any of its ingredients.
• Requires close monitoring of liver function, especially in patients with pre-existing liver conditions, as it may cause liver-related issues.
• Should be used with caution in patients with diabetes as it can affect blood sugar levels.
• May cause flushing, itching, and gastrointestinal discomfort, particularly when starting treatment.
• Patients with a history of gastrointestinal issues should exercise caution, as it may worsen these conditions.
• Niacin can impact blood pressure, so patients with hypertension should be monitored regularly.
• Not recommended for pregnant or breastfeeding women unless advised by a healthcare professional.

Following are the drug interactions for Niacin Tablet:

• Niacin can interact with statins (e.g., simvastatin, atorvastatin), increasing the risk of muscle-related side effects such as myopathy or rhabdomyolysis. If used together, monitoring for muscle pain or weakness is recommended.
• Concurrent use of Niacin with blood pressure-lowering medications (e.g., beta-blockers, ACE inhibitors) may exacerbate hypotension (low blood pressure), especially when standing up. Blood pressure should be monitored.
• Niacin can increase the effects of antihypertensive drugs, potentially causing significant drops in blood pressure. Caution is advised when starting or adjusting doses of antihypertensive medications.
• The combination of Niacin and anticoagulants (e.g., warfarin) may increase the risk of bleeding. Regular monitoring of prothrombin time (PT) and international normalized ratio (INR) may be necessary.
• Niacin may interact with other medications that affect liver function (e.g., acetaminophen, alcohol), increasing the risk of liver toxicity. Liver function tests should be performed regularly, especially with prolonged use.
• When taken with certain diabetic medications (e.g., insulin, sulfonylureas), Niacin can increase blood sugar levels, potentially affecting glucose control in diabetic patients. Blood glucose levels should be monitored.
• Combining Niacin with bile acid sequestrants (e.g., cholestyramine) may reduce the absorption of Niacin, requiring separation of doses by at least 4-6 hours.
• Niacin can interact with other cholesterol-lowering drugs, such as fibrates (e.g., gemfibrozil), increasing the risk of gallstones and liver damage. Careful monitoring for side effects is advised.
• The use of Niacin with alcohol may increase the risk of side effects, such as flushing, liver damage, and gastrointestinal distress. It is advisable to limit alcohol intake during treatment.

Following are the food interactions for Niacin Tablet:

• Niacin may cause flushing when taken with alcohol, leading to redness, itching, and a warm feeling.
• Avoid excessive consumption of foods high in niacinamide (a form of niacin) like liver, yeast, bran, peanuts, and beans, as it can lead to imbalances and potential side effects.
• Grapefruit juice should be consumed cautiously as it may interfere with niacin metabolism, affecting its efficacy.
• Niacin can interact with high-fat meals, potentially causing flushing and gastrointestinal discomfort.
• Spicy foods might exacerbate the flushing effect of niacin, leading to temporary skin redness and warmth.
• Limit caffeine intake, as it may enhance niacin's flushing effect and cause discomfort.
• Certain herbal teas, especially those with niacin-rich ingredients, might influence niacin's effects and should be consumed in moderation.
• Always consult a healthcare professional for personalized advice on diet and medication interactions.

Niacin Tablets should be stored in a cool and dry environment, preferably at room temperature, ensuring protection from light and moisture. Maintain the original packaging to preserve the tablets' integrity and prevent contamination. Avoid exposing the tablets to extreme temperatures, including heat sources like radiators or direct sunlight, as this can compromise their effectiveness. Pay attention to the expiration date on the packaging, and responsibly dispose of any unused or expired tablets. Do not dispose of them in toilets or drains; instead, seek advice from your pharmacist or healthcare provider for appropriate disposal methods. Keep Niacin Tablets securely stored, out of the reach of children, to prevent accidental consumption.

Following are the quick tips for Niacin Tablet:

• Consult your doctor for the right dosage, as it varies based on your medical condition.
• Take the tablet with a full glass of water to ensure proper swallowing.
• Avoid crushing or chewing the tablet; swallow it whole.
• Niacin can cause a flushing reaction, so be prepared for temporary redness, warmth, and itching.
• Do not take the tablet on an empty stomach; have it with a meal to reduce side effects.
• Inform your doctor about all medications you are taking to avoid interactions.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.