Nicodil (10mg) 100 Tablets

Nicorandil's mechanism of action involves two primary effects ,vasodilation and protection against myocardial ischemia. As a potassium channel activator, Nicorandil directly opens ATP-sensitive potassium channels in vascular smooth muscle cells, leading to hyperpolarization of the cell membrane and subsequent relaxation of the vascular smooth muscle. This action results in dilation of both epicardial coronary arteries and peripheral vessels, thereby improving blood flow to the myocardium and reducing its workload. Additionally, Nicorandil's nitrate-like effect contributes to vasodilation by releasing nitric oxide, which activates soluble guanylate cyclase, leading to increased cyclic GMP levels and subsequent vascular smooth muscle relaxation. These combined actions of Nicorandil help in the treatment of angina by enhancing blood flow to the heart and reducing the oxygen demand of the myocardium.

Potassium channel activator

Tablet

The following are the uses of Nicorandil Tablet:

• Used for Angina, providing relief from chest pain and improving blood flow to the heart.
• Used to relax and widen blood vessels, reducing the workload on the heart.
• Used in the management of chronic stable angina and variant angina.
• Used to improve exercise tolerance and reduce the frequency of angina attacks.
• Used as a long-term treatment to prevent angina symptoms.
• Used to treat conditions where blood vessels in the heart may spasm.
• Used to enhance oxygen supply to the heart muscle.

The usual therapeutic range is 10 to 20 mg twice daily. The usual starting dose is 10 mg twice daily, in the morning and the evening preferably.

In the case of an overdose of Nicorandil Tablets, it is important to recognize the potential symptoms, which may include severe hypotension, dizziness, and lightheadedness. Prompt action is necessary; contact a healthcare professional or a poison control center immediately for guidance. They will provide specific instructions and may recommend immediate medical treatment to manage the overdose effectively. It is crucial to act swiftly and seek assistance to ensure the best possible outcome.

In the case of a missed dose of Nicorandil Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you have missed multiple doses, contact your healthcare professional for advice on how to safely resume your medication. It is crucial to maintain a consistent medication routine, but if you frequently miss doses, consult your doctor to discuss the best course of action.

To take Nicorandil Tablets, swallow the tablet whole with a glass of water, following the prescribed dosage as directed by your healthcare provider, typically taken twice daily, and it is important to maintain consistency in the timing of each dose for optimal effectiveness.

Here are the conditions and situations when Nicorandil Tablet should not be used:

• Must not be used in patients with a known allergy or hypersensitivity to Nicorandil or any of its excipients.
• Contraindicated in individuals with unstable angoric pectoris (chest pain) or who have recently had a heart attack.
• Not suitable for patients with severe low blood pressure (hypotension) or who are experiencing shock.
• Should not be used in patients with aortic stenosis, a condition where the aortic valve in the heart is narrowed.
• Contraindicated during pregnancy and breastfeeding.
• Not recommended for individuals with active peptic ulcer disease or a history of gastrointestinal bleeding.
• Should be avoided in patients with severe kidney disease or liver impairment.
• Not suitable for individuals with conditions that may cause low white blood cell counts (neutropenia).
• Must not be used in patients with a history of retinal hemorrhage (bleeding in the eye) or retinal artery occlusion.

The side effects of Nicorandil Tablet may include:

• Headache
• Dizziness
• Nausea and vomiting
• Diarrhea
• Flushing (feeling warm)
• Skin rashes or itching
• Low blood pressure (hypotension)
• Allergic reactions, including swelling of the face, lips, or throat.

Following are the precautions and warnings for Nicorandil Tablet:

• Not recommended for individuals with a known allergy or sensitivity to Nicorandil or any of its excipients.
• Patients with severe liver or kidney disease should use this medication with caution, as it may require dosage adjustments.
• Nicorandil can cause a sudden drop in blood pressure, leading to lightheadedness or fainting, especially when standing up from a sitting or lying position. Patients should exercise caution and avoid situations where sudden dizziness could be dangerous.
• Patients with a history of heart problems, such as unstable angina, should be closely monitored while taking this medication.
• It may cause skin flushing and sweating. If these symptoms are severe or persistent, medical advice should be sought.
• Nicorandil may cause chest pain in some individuals. If chest pain becomes severe or persistent, immediate medical attention is necessary.
• Not recommended for use during pregnancy or breastfeeding unless the potential benefits outweigh the risks, as determined by a healthcare professional.

Following are the drug interactions for Nicorandil Tablet:

• Concurrent use with nitrates (e.g., nitroglycerin) can result in excessive blood pressure reduction and increased risk of hypotension.
• The effect of Nicorandil may be reduced when taken with rifampicin, a strong enzyme inducer.
• Antihypertensive medications like beta-blockers and ACE inhibitors can have additive effects with Nicorandil, leading to excessive blood pressure drop.
• Combining Nicorandil with diuretics may increase the risk of dehydration and electrolyte imbalances.
• Blood glucose levels should be closely monitored when using Nicorandil with insulin or oral hypoglycemic agents.
• Caution is advised when taking Nicorandil with other vasodilators, as it may enhance their effects and lead to hypotension.
• Nicorandil may interact with certain anticoagulants, such as warfarin, potentially affecting blood clotting and requiring close monitoring.

Following are the food interactions to be aware of when taking Nicorandil Tablets:

• Avoid excessive alcohol consumption as it may increase the risk of side effects, particularly flushing, dizziness, and low blood pressure.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Nicorandil, potentially leading to increased drug levels in the body.
• Caffeine-rich beverages like coffee and tea may interact with Nicorandil, causing increased heart rate and blood pressure fluctuations.
• High-fat meals may delay the absorption of Nicorandil, potentially reducing its effectiveness.
• Avoid eating large amounts of salty foods as they can counteract the effects of Nicorandil on blood pressure.
• Certain dairy products like milk and yogurt may decrease the absorption of Nicorandil; consider taking the medication with water instead.
• Spicy foods might cause an increased risk of flushing and gastrointestinal discomfort when combined with Nicorandil.
• Always consult your healthcare provider for personalized advice on dietary considerations while taking Nicorandil.

Nicorandil Tablets should be stored in a secure and dry place, preferably at room temperature, ensuring protection from light and moisture. The tablets should remain in their original packaging or container, tightly sealed, to maintain their integrity and effectiveness. It is crucial not to expose the medication to extreme temperatures or humidity, so avoid storing it in the bathroom, kitchen, or near heat sources. Regularly check the expiration date, and if the tablets are past their expiry or no longer needed, proper disposal is essential. Do not dispose of Nicorandil Tablets by flushing them or pouring them down the drain; instead, consult a pharmacist or healthcare professional for safe disposal methods. Keep the medication out of children's reach to prevent accidental consumption.

No

Following are the quick tips for Nicorandil Tablet:

• Adhere to the prescribed dosage and duration of treatment as advised by your doctor.
• Take the tablet with or without food, but be consistent with your choice.
• Swallow the tablet whole with a full glass of water to aid in swallowing.
• Avoid crushing, chewing, or breaking the tablet, as it should be taken intact.
• If you have difficulty swallowing, explore alternative methods with your doctor.
• Regularly monitor your blood pressure and heart rate as advised by your healthcare provider.
• Store Nicorandil tablets in a cool, dry place, away from direct sunlight and moisture.