NICOR SYP

Diphenhydramine is an antihistamine that blocks H1 receptors, reducing histamine-induced symptoms. Pseudoephedrine, a sympathomimetic, acts on alpha-adrenergic receptors in the respiratory tract, leading to vasoconstriction and decreased congestion. Paracetamol, an analgesic and antipyretic, primarily inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis. Pholcodine, an opioid antitussive, suppresses the cough reflex by acting on the central nervous system, specifically the cough center in the medulla oblongata.

Cough Suppressant, Antihistamine, Decongestant, Analgesic

Suspension

The following are the uses of Diphenhydramine, Pseudoephedrine, paracetamol, pholocodine Syrup/Suspension:

• Used for relieving symptoms of the common cold, such as runny nose, sneezing, and congestion.
• Used to reduce mild to moderate pain, such as headaches, toothaches, and muscle aches.
• Used for suppressing dry, unproductive coughs and reducing throat irritation.
• Used to treat allergic reactions and relieve symptoms like itching, hives, and sneezing.
• Used for reducing fever and managing discomfort associated with flu-like symptoms.
• Used to temporarily relieve symptoms of allergic rhinitis, including watery eyes and nasal congestion.
• Used to help individuals fall asleep and treat short-term insomnia.
• Used for providing temporary relief from upper respiratory symptoms associated with allergies.

In the case of overdose of Diphenhydramine, symptoms may include extreme drowsiness, confusion, and irregular heartbeat. For Pseudoephedrine, expect increased heart rate, high blood pressure, and potential hallucinations. Paracetamol overdose can lead to liver damage and abdominal pain. Pholcodine overdose may result in severe respiratory depression and even loss of consciousness. Prompt medical intervention is necessary for all these overdoses to prevent serious health consequences.

In the case of a missed dose of Diphenhydramine, Pseudoephedrine, Paracetamol, or Pholcodine Syrup/Suspension, it is recommended to take the medication as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Avoid taking extra medicine to make up for the missed dose, as this may lead to an increased risk of side effects. It is important to maintain a consistent dosing routine for these medications.

To administer the Diphenhydramine, Pseudoephedrine, paracetamol, pholocodine Syrup/Suspension, shake the bottle vigorously to ensure a homogeneous mixture, then accurately measure the prescribed dose using a measuring cup or oral syringe, and take it orally as directed by your healthcare professional, typically once or twice a day, with or without food, adhering to the recommended dosage guidelines for optimal effectiveness and safety.

Here are the situations when Diphenhydramine, Pseudoephedrine, Paracetamol, and Pholcodine Syrup/Suspension should not be used:

• Avoid in individuals with a known allergy or hypersensitivity to any of the active ingredients, including Diphenhydramine, Pseudoephedrine, Paracetamol, or Pholcodine.
• Contraindicated in patients with narrow-angle glaucoma, as it can worsen the condition.
• Should not be used in individuals with severe high blood pressure, heart disease, or cardiovascular disorders.
• Not recommended for patients with difficulty in urination due to an enlarged prostate gland.
• Avoid in patients with severe liver impairment or liver disease.
• Contraindicated during the last stages of pregnancy, as it may cause premature closure of the fetal ductus arteriosus.
• Should not be used in infants or young children, especially those under 2 years of age, due to potential severe side effects.
• Avoid in individuals with a history of seizures or epilepsy, as it may lower the seizure threshold.
• Not suitable for patients with diabetes, as it may affect blood sugar control.
• Should not be used in individuals with a history of gastrointestinal obstruction or narrow-angle closure.
• Contraindicated in patients taking monoamine oxidase inhibitor (MAOI) medications or within 14 days of stopping MAOIs.

The side effects of Diphenhydramine, Pseudoephedrine, Paracetamol, and Pholcodine Syrup/Suspension may include:

• Drowsiness or sedation
• Dry mouth
• Blurred vision
• Nausea and vomiting
• Constipation or diarrhea
• Increased heart rate
• Dizziness or lightheadedness
• Restlessness or nervousness

Following are the precautions and warnings for Diphenhydramine, Pseudoephedrine, Paracetamol, and Pholcodine Syrup/Suspension:

• Do not use this medication if you are allergic to any of its ingredients, including diphenhydramine, pseudoephedrine, paracetamol, or pholcodine.
• This medication may cause drowsiness or dizziness, so avoid driving or operating heavy machinery until you know how it affects you.
• Alcohol consumption should be avoided as it may intensify the sedative effects of diphenhydramine.
• Patients with heart disease, high blood pressure, diabetes, thyroid problems, or prostate issues should use this medication with caution and under medical supervision.
• Not recommended for use in children under 6 years old unless prescribed by a healthcare professional.
• Pregnant and breastfeeding women should consult their doctor before taking this medication as it may pass into breast milk.
• Do not exceed the recommended dosage, as excessive use of pseudoephedrine and paracetamol can lead to serious side effects.

Following are the drug interactions for Diphenhydramine, Pseudoephedrine, Paracetamol, and Pholcodine Syrup/Suspension:

• Alcohol and other central nervous system (CNS) depressants (e.g., benzodiazepines, opioids) may enhance the sedative effects of Diphenhydramine, potentially causing excessive drowsiness and impaired motor skills.
• Monoamine oxidase inhibitors (MAOIs) should be avoided with Pseudoephedrine as they can increase blood pressure and heart rate.
• Paracetamol may interact with warfarin and other anticoagulants, requiring close monitoring of international normalized ratio (INR) values.
• Pholcodine can interact with other CNS depressants, including alcohol, increasing sedation and respiratory depression risks.
• Antihistamines like Diphenhydramine can reduce the effectiveness of cough medicines containing Pholcodine.
• Pseudoephedrine may decrease the effectiveness of beta-blockers and increase blood pressure.
• Paracetamol can potentially cause liver damage when taken with other potentially hepatotoxic drugs.

Following are the food interactions for Diphenhydramine, Pseudoephedrine, paracetamol, pholocodine Syrup/Suspension:

• Grapefruit and grapefruit juice consumption should be avoided as they can increase the concentration of the medication in the blood, potentially leading to increased side effects.
• Alcohol is not recommended as it can enhance the sedative effects of Diphenhydramine, causing excessive drowsiness and dizziness.
• Caffeine-containing beverages like coffee, tea, or energy drinks may counteract the sedative effect of Diphenhydramine and should be limited.
• Avoid eating large meals before or after taking the medication, especially if it contains paracetamol, as it may affect the absorption and increase the risk of liver-related side effects.
• Spicy foods may increase nasal congestion and should be consumed sparingly, especially when taking Pseudoephedrine.
• Chocolate, especially dark chocolate, contains compounds that can interact with Pseudoephedrine and should be consumed in moderation.
• It is generally advisable to maintain a balanced diet and ensure adequate hydration while taking this medication.

Diphenhydramine, Pseudoephedrine, paracetamol, and pholcodine Syrup/Suspension should be stored in a cool, dry area, away from direct sunlight and moisture, preferably in its original container with the cap tightly secured. Room temperature is ideal for storage, avoiding extreme heat or cold. Always check the expiration date before use and never use expired medication. When disposing of the syrup, do not flush it or pour it down the drain; instead, follow local guidelines or consult a pharmacist for safe disposal methods. Keep the medication out of children's reach to prevent accidental consumption. Proper storage and disposal practices are essential for the safety and effectiveness of these medications.

Following are the quick tips for Diphenhydramine, Pseudoephedrine, Paracetamol, Pholcodine Syrup/Suspension:

• Consult a healthcare professional for dosage instructions based on your age and condition.
• Measure the syrup accurately using the provided measuring cup or spoon.
• Store the medication at room temperature, away from direct sunlight and moisture.
• Avoid alcohol consumption while taking this medication to prevent adverse interactions.
• Inform your doctor about any other medications or supplements you are taking.
• Do not drive or operate heavy machinery until you know how the medication affects you.
• Contact your doctor if symptoms persist or worsen despite taking the medication.