NIGHT CARE CAP

Dextromethorphan, a component of the capsule, acts centrally as a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, increasing the pain threshold. It also has sigma ligand and serotonin reuptake inhibitory properties, which contribute to its antitussive effect. Paracetamol is believed to inhibit the synthesis of prostaglandins in the central nervous system, which in turn reduces pain and fever. Promethazine, an H1-anticholinergic receptor antagonist, blocks histamine receptors and exerts an antiemetic effect by antagonizing the stimulation of the vomiting centre in the medulla.

Dextromethorphan, Paracetamol, Promethazine

Antitussive, Analgesic, Antihistamine

Capsule

The following are the uses of dextromethorphan, Paracetamol, Promethazine (HCl) Capsule:

• Used for suppressing coughs and relieving symptoms of upper respiratory tract infections.
• Used to relieve mild to moderate pain and reduce fever.
• Used to relieve symptoms of allergies, such as itching, runny nose, and sneezing.
• Used to prevent and treat nausea and vomiting, especially in cases of motion sickness.
• Used for temporary relief of symptoms associated with the common cold, flu, or allergies.
• Used to promote relaxation and improve sleep in cases of insomnia or restlessness.
• Used to manage symptoms of upper respiratory allergies and hay fever.

In the case of an overdose of Dextromethorphan, Paracetamol, and Promethazine (HCl) Capsules, individuals may experience symptoms such as nausea, vomiting, dizziness, and confusion. Severe cases can lead to respiratory depression, liver damage, and even loss of consciousness. Prompt medical intervention is necessary, including gastric lavage, administration of activated charcoal, and supportive care to manage symptoms and prevent further complications. It is vital to seek emergency medical assistance immediately if an overdose is suspected.

In the case of a missed dose of dextromethorphan, Paracetamol, and Promethazine (HCl) Capsule, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. It is important to maintain a consistent medication routine, but if you frequently miss doses, consult your healthcare provider for advice on how to manage your medication effectively.

To take the Dextromethorphan, Paracetamol, and Promethazine (HCl) Capsule, simply swallow the capsule whole with a glass of water, preferably with or after a meal, following the dosage instructions provided by your healthcare professional, ensuring you do not exceed the prescribed amount.

The following conditions or situations are contraindications for taking Dextromethorphan, Paracetamol, and Promethazine (HCl) Capsules:

• Allergy or hypersensitivity to any of the active ingredients (dextromethorphan, paracetamol, or promethazine HCl) or to any of the capsule's components.
• Not suitable for patients with severe breathing problems or respiratory depression.
• Contraindicated in patients with a history of asthma, chronic obstructive pulmonary disease (COPD), or other lung diseases.
• Should not be used in individuals with narrow-angle glaucoma.
• Not recommended for patients with a history of seizures or epilepsy.
• Avoid in patients with liver disease or a history of liver problems, as it may cause liver damage.
• Should not be used in patients with severe kidney disease or kidney impairment.
• Contraindicated in children under 2 years of age due to the risk of respiratory depression.
• Avoid alcohol consumption while taking this medication as it may increase the risk of liver damage and enhance the sedative effects.
• Not suitable for individuals who are currently taking certain medications such as monoamine oxidase inhibitors (MAOIs), other sedatives, or opioids.

The side effects of dextromethorphan, Paracetamol, and Promethazine (HCl) Capsule may include:

• Drowsiness or sedation (feeling sleepy)
• Dry mouth
• Blurred vision
• Constipation
• Nausea and vomiting
• Dizziness or lightheadedness
• Allergic reactions (such as rash, itching, or difficulty breathing)
• Confusion or disorientation

Following are the precautions and warnings for dextromethorphan, paracetamol, and promethazine HCl capsules:

• Do not use this medication if you are allergic to any of its ingredients, including dextromethorphan, paracetamol, or promethazine.
• This medication may cause drowsiness or dizziness, so patients should avoid driving, operating heavy machinery, or performing tasks that require mental alertness until they know how the medication affects them.
• Alcohol consumption should be avoided as it may enhance the sedative effects of promethazine.
• Patients with liver or kidney disease should use this medication with caution and under medical supervision as it may affect these organs.
• Promethazine may cause respiratory depression, especially in children and elderly patients. Monitor for breathing difficulties.
• Dextromethorphan should be used with caution in patients with a history of respiratory issues, as it may suppress cough reflex.
• Paracetamol has a narrow therapeutic index; prolonged use or overdose may lead to liver damage. Do not exceed the recommended dosage.
• This medication may cause drug interactions; inform your doctor about all medications you are currently taking.

Following are the drug interactions for Dextromethorphan, Paracetamol, and Promethazine HCl Capsule:

• It may cause excessive drowsiness when taken with other central nervous system (CNS) depressants like benzodiazepines, alcohol, or opioids.
• Dextromethorphan can interact with monoamine oxidase inhibitors (MAOIs), increasing the risk of serotonin syndrome.
• Paracetamol may prolong the effects of warfarin and other anticoagulants, requiring close monitoring of INR values.
• Promethazine can lower the seizure threshold; caution is advised when used with anticonvulsants.
• Antihistamines like promethazine can reduce the effectiveness of levodopa in Parkinson's disease.
• The sedative effects of promethazine may be increased by other medications that also cause sedation, such as certain antidepressants or antipsychotics.
• Dextromethorphan metabolism can be affected by CYP2D6 inhibitors, leading to higher plasma levels and potential toxicity.
• Antacids may decrease the absorption of promethazine, so they should be taken at least 2 hours apart.

Following are the food interactions for Dextromethorphan, Paracetamol, and Promethazine HCl Capsule:

• Alcohol should be avoided or limited as it can intensify the sedative effects of Promethazine and may increase the risk of dizziness, drowsiness, and impaired coordination.
• Grapefruit and grapefruit juice should be consumed with caution as they can inhibit the metabolism of Dextromethorphan, leading to increased drug levels and potential side effects, including drowsiness and impaired judgment.
• Caffeine and energy drinks should be avoided as they may interact with Promethazine, causing increased nervousness, anxiety, and sleep disturbances.
• Fatty foods may slow down the absorption of Paracetamol, potentially affecting its onset of action. It is advisable to take the medication on an empty stomach or with a light meal.
• Avoid eating large, high-fat meals while taking this medication, as it can affect the absorption and distribution of Promethazine.
• Promethazine may cause dry mouth, so staying well-hydrated and drinking plenty of fluids is recommended.
• Certain foods containing tyramine, such as aged cheeses, cured meats, and fermented foods, should be avoided when taking Promethazine, as they may interact and cause a spike in blood pressure.
• It is generally advisable to consult with a healthcare professional or pharmacist for personalized advice regarding food interactions, especially if you have specific dietary concerns or medical conditions.

Store dextromethorphan, paracetamol, and promethazine (HCl) capsules in a dry, cool place, maintaining a temperature below 25°C. Keep the medication in its original container, tightly sealed, to maintain its integrity and prevent exposure to light and moisture. Do not store in bathrooms or near sinks due to humidity concerns. Regularly check the expiration date, and dispose of any expired or unused capsules responsibly. Never flush medications or pour them into drainage systems; consult a pharmacist or healthcare professional for appropriate disposal methods. Ensure the medication is kept out of children's reach to prevent accidental consumption.

Following are the quick tips for Dextromethorphan, Paracetamol, and Promethazine HCl Capsule:

• Swallow the capsule whole with water, do not crush or chew.
• Take the medication as directed by your doctor or pharmacist.
• It is best to take the capsule with food to prevent stomach upset.
• Avoid taking more than the prescribed dose, and do not take it for longer than recommended.
• Do not drive or operate machinery until you know how the medication affects you.
• Inform your doctor if you have any medical conditions or allergies before taking this medication.
• Store the capsules in a cool, dry place, away from direct sunlight and moisture.