Niglys SR (2.6mg) 30 Capsules

Glyceryl Trinitrate, the active ingredient in the 2.6mg capsule, exerts its therapeutic effects primarily through its conversion to nitric oxide (NO) in the body. Once absorbed, Glyceryl Trinitrate undergoes metabolic processes, primarily in the smooth muscle cells of blood vessels, where it is reduced to nitric oxide. Nitric oxide is a potent vasodilator, meaning it relaxes the smooth muscles in the walls of blood vessels, leading to their widening or dilation. This vasodilation results in decreased vascular resistance, which subsequently lowers blood pressure and reduces the workload on the heart. By dilating both arterial and venous blood vessels, Glyceryl Trinitrate improves blood flow and oxygen delivery to the heart, thereby alleviating angina (chest pain) and managing conditions such as heart failure and coronary artery disease. The mechanism of action specifically targets the cardiovascular system, making it a valuable medication for managing various cardiovascular disorders.

Glyceryl Trinitrate 2.6mg

vasodilator

Capsule

The following are the uses of Glyceryl Trinitrate 2.6mg Capsule:

• Used for treating and preventing chest pain caused by reduced blood flow to the heart.
• Used for Angina, a condition where the heart doesn't get enough oxygen due to narrowed arteries.
• Used to relax and dilate blood vessels, improving blood flow.
• Used in emergency situations for acute heart failure, providing rapid relief.
• Used to reduce the workload on the heart, preventing further damage.
• Used for managing blood pressure during surgeries, ensuring optimal circulation.
• Used as a preventive measure for individuals with a history of heart-related issues.

In the case of an overdose of Glyceryl Trinitrate 2.6mg Capsules, individuals may experience severe headaches, dizziness, and a sudden drop in blood pressure. This can lead to fainting, rapid heartbeat, and difficulty breathing. Promptly seek medical assistance if you suspect an overdose, as emergency treatment may be necessary to manage these symptoms and prevent potential complications. It is crucial to act quickly to ensure the individual's safety and well-being.

In the case of a missed dose of Glyceryl Trinitrate 2.6mg Capsule, it is important to take the dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one. Never take extra medication to make up for a forgotten dose. If you have missed multiple doses, contact your healthcare provider for advice, as they may recommend adjusting your dosage schedule to ensure you receive the correct amount of medication.

To use Glyceryl Trinitrate 2.6mg Capsule, place the capsule under your tongue and allow it to dissolve completely, following the instructions provided by your healthcare professional; take it as directed, typically 1 capsule every 5 minutes for a maximum of 3 doses, and seek medical attention if chest pain persists or worsens.

Situations to avoid using Glyceryl Trinitrate 2.6mg Capsules:

• Do not use if you have an allergy or sensitivity to Glyceryl Trinitrate or other nitrates.
• Contraindicated in patients with severe anemia or recent head injury.
• Should not be taken by individuals with narrow-angle glaucoma.
• Avoid using if you have a recent heart attack or severe heart failure.
• Not recommended for patients with hypotension (low blood pressure).
• Do not use if you have a blood disorder called methemoglobinemia.
• Contraindicated in patients with increased intracranial pressure.

The side effects of Glyceryl Trinitrate 2.6mg Capsule may include:

• Headache (common and due to blood vessel dilation)
• Dizziness or lightheadedness
• Flushing or redness of the skin
• Low blood pressure (hypotension)
• Weakness or fatigue
• Rapid heartbeat (tachycardia)
• Nausea or vomiting
• Dry mouth
• Tolerance with prolonged use, reducing the drug’s effectiveness
• Skin rash or itching in some individuals
• Fainting or dizziness when standing up quickly (orthostatic hypotension)

Following are the precautions and warnings for Glyceryl Trinitrate 2.6mg Capsule:

• This medication is for oral use only; do not attempt to crush, chew, or open the capsule.
• Patients with a known allergy to Glyceryl Trinitrate or any nitrates should not use this medication.
• Exercise caution in patients with low blood pressure as this medication can cause a further drop in blood pressure.
• It may cause dizziness and lightheadedness, so patients should avoid driving or operating heavy machinery until they know how this medication affects them.
• Alcohol consumption should be avoided as it may increase the risk of side effects.
• Not recommended for use during pregnancy and breastfeeding unless advised by a healthcare professional.
• Keep out of reach of children and pets.

Following are the drug interactions for Glyceryl Trinitrate 2.6mg Capsule:

• Phosphodiesterase inhibitors like sildenafil, tadalafil, and vardenafil can significantly increase the hypotensive effects of glyceryl trinitrate, leading to a dangerous drop in blood pressure.
• Combining with other vasodilators such as hydralazine or minoxidil may result in excessive vasodilation and hypotension.
• Antihypertensive medications (e.g., beta-blockers, ACE inhibitors) can have additive effects on blood pressure, potentially causing hypotension.
• Alcohol consumption can intensify the vasodilatory and hypotensive effects of glyceryl trinitrate, increasing the risk of dizziness and fainting.
• Drugs that inhibit the metabolism of glyceryl trinitrate, such as erythromycin and clarithromycin, may increase its levels in the body, leading to prolonged effects.
• It may interact with certain calcium channel blockers, like amlodipine, enhancing vasodilation and potentially causing excessive hypotension.
• The use of glyceryl trinitrate with diuretics, particularly loop diuretics, can lead to excessive fluid loss and hypotension.

Following are the food interactions for Glyceryl Trinitrate 2.6mg Capsule:

• Alcohol consumption should be avoided as it may increase the risk of hypotension and dizziness, intensifying the medication's side effects.
• Grapefruit and grapefruit juice are to be avoided as they can interfere with the metabolism of Glyceryl Trinitrate, potentially leading to increased drug levels and heightened side effects.
• High-fat meals may slightly delay the absorption of the medication, but it is generally well-tolerated with food.
• Caffeine intake should be monitored as it can increase heart rate and blood pressure, counteracting the medication's effects.
• Avoid excessive salt or sodium-rich foods, as they can reduce the anti-hypertensive effect of Glyceryl Trinitrate.
• Ensure a balanced diet, as some vitamins and minerals like Vitamin B and potassium can help manage cardiovascular health.
• Stay hydrated by drinking enough water to maintain blood volume and prevent hypotension.
• Limit sugary foods and beverages, as they may influence cardiovascular health and interact with the medication's efficacy.

Glyceryl Trinitrate 2.6mg Capsules should be stored in a cool and dry place, preferably at room temperature (below 25°C). Protect the capsules from direct sunlight, heat, and moisture by keeping them in their original packaging, ensuring the container is tightly closed. It is crucial not to store the medication in the bathroom or kitchen cabinets, as these areas can be susceptible to temperature fluctuations. Always check the expiry date before use, and never use the capsules if they appear damaged or discolored. When it comes to disposal, do not flush the capsules down the toilet or pour them into drainage systems. Instead, consult your pharmacist or local waste management guidelines for safe and environmentally friendly disposal practices. Keep this medication securely locked away from children and pets to prevent accidental ingestion.

Following are the quick tips for Glyceryl Trinitrate 2.6mg Capsule:

• Store capsules in a cool, dry place, away from direct sunlight and moisture.
• Always carry the medication with you, especially when traveling, to ensure you have it when needed.
• Consult your doctor if you have any heart conditions or are taking other medications.
• Inform your healthcare provider if you experience severe headaches or dizziness.
• Do not crush or chew the capsule; swallow it whole with water.
• Do not stop taking the medication suddenly without medical advice.
• Contact your doctor if your symptoms worsen or do not improve.