Niglys SR (6.4mg) 30 Capsules

Glyceryl Trinitrate, commonly known as nitroglycerin, works primarily by relaxing smooth muscle cells within the walls of blood vessels, a process mediated by its conversion to nitric oxide (NO) in the body. When administered, it rapidly diffuses across cell membranes and is metabolized to release NO. Nitric oxide activates the enzyme guanylate cyclase, leading to an increase in cyclic guanosine monophosphate (cGMP) levels. This rise in cGMP causes smooth muscle relaxation, particularly in the veins and arteries, leading to vasodilation. The vasodilation decreases vascular resistance, reduces the workload on the heart, and lowers blood pressure. This mechanism of action is particularly beneficial in conditions where rapid reduction of blood pressure or relief from angina (chest pain) is required, as it improves blood flow and reduces the oxygen demand of the heart.

Glyceryl Trinitrate 6.4mg

vasodilator

Capsule

The following are the uses of Glyceryl Trinitrate 6.4mg Capsule:

• Glyceryl Trinitrate is commonly used in the treatment of angina (chest pain) and helps to relieve symptoms associated with heart conditions.
• The capsule form is typically used to prevent chest pain or to manage episodes of angina in individuals with heart disease.
• It helps to prevent and manage conditions like heart failure, myocardial infarction (heart attack), and other cardiovascular conditions.
• Glyceryl Trinitrate can also be prescribed to manage hypertension (high blood pressure) in certain cases.

In the case of an overdose of Glyceryl Trinitrate 6.4mg Capsules, individuals may experience severe symptoms such as a sudden drop in blood pressure, rapid or irregular heartbeat, severe headaches, dizziness, and fainting. Promptly seek medical assistance if an overdose is suspected. The doctor may recommend immediate hospitalization for monitoring and treatment, which could include supportive care and medications to manage specific symptoms.

In the case of a missed dose of Glyceryl Trinitrate 6.4mg Capsule, it is important to take the dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. However, if you have missed multiple doses, it is best to consult your healthcare provider for guidance on how to safely resume your medication regimen. They will advise you on whether to adjust the timing or dosage of your next dose to ensure the medication's effectiveness.

To use Glyceryl Trinitrate 6.4mg Capsule, place the capsule under your tongue, allowing it to dissolve completely, and avoid swallowing or chewing for optimal absorption.

Following are the conditions/situations when Glyceryl Trinitrate 6.4mg Capsule should not be used:

• Must not be taken by individuals with known sensitivity or allergy to Glyceryl Trinitrate or other nitrates.
• Not suitable for patients with severe anemia.
• Contraindicated in individuals with recent head injury or increased intracranial pressure.
• Should not be used in patients with severe aortic or mitral valve stenosis (narrowing of the heart valves).
• Avoid using in patients with a recent heart attack (acute myocardial infarction) complicated by either congestive heart failure or reduced heart function.
• Not recommended for individuals with low blood pressure (hypotension).
• Must not be used to treat certain types of chest pain (angina) like Prinzmetal's angina.
• Contraindicated during the treatment of sexual dysfunction, especially with medications containing PDE-5 inhibitors.
• Should be avoided in patients with glaucoma.

The side effects of Glyceryl Trinitrate 6.4mg Capsule may include:

• Severe headaches
• Dizziness or lightheadedness
• Nausea and vomiting
• Flushing or redness of the skin
• Palpitations or increased heart rate
• Drop in blood pressure (hypotension)
• Skin rashes or itching
• Dry mouth

Following are the precautions and warnings for Glyceryl Trinitrate 6.4mg Capsule:

• This medication is for oral use only and should not be chewed, crushed, or opened, as it has a specific release mechanism.
• Not recommended for individuals with a known allergy to Glyceryl Trinitrate or similar substances.
• Patients with a history of severe anemia, recent heart attack, or head injury should use with caution and under medical supervision.
• May cause dizziness or lightheadedness; patients should avoid driving, operating heavy machinery, or performing tasks that require alertness until the effects are known.
• Alcohol consumption should be avoided as it may increase the risk of side effects and worsen dizziness.
• Patients with low blood pressure should use with caution, as it may cause a further drop in blood pressure.
• Always inform your doctor about all medications you are currently taking to avoid potential drug interactions.
• Store Glyceryl Trinitrate capsules in a cool, dry place, away from direct sunlight and moisture.

Following are the drug interactions for Glyceryl Trinitrate 6.4mg Capsule:

• Alcohol and sildenafil can enhance the hypotensive effect, leading to excessive blood pressure drop.
• Drugs that release nitric oxide, such as molsidomine and sodium nitroprusside, may cause severe hypotension when used with Glyceryl Trinitrate.
• Phosphodiesterase inhibitors like sildenafil, vardenafil, and tadalafil can increase the risk of hypotension and worsen its severity.
• Beta-blockers and diuretics may reduce the effectiveness of Glyceryl Trinitrate, as they can blunt its vasodilatory effects.
• Antihypertensive medications, when used concomitantly, may result in additive blood pressure-lowering effects.
• Calcium channel blockers can potentially increase the vasodilatory and hypotensive effects of Glyceryl Trinitrate.
• Certain medications metabolized by the liver, such as erythromycin and ketoconazole, may affect the metabolism of Glyceryl Trinitrate, leading to increased side effects.

Following are the food interactions for Glyceryl Trinitrate 6.4mg Capsule:

• Alcohol consumption should be avoided as it may increase the risk of hypotension and dizziness, intensifying the drug's side effects.
• Grapefruit and grapefruit juice should be consumed with caution as they can inhibit enzymes responsible for metabolizing the drug, potentially leading to increased drug levels in the blood.
• High-fat meals may delay the absorption of Glyceryl Trinitrate, affecting its rapid onset of action.
• Caffeine intake should be monitored as it can constrict blood vessels, potentially reducing the effectiveness of the medication.
• Avoid consuming large amounts of salt or highly salty foods, as this can counteract the medication's effects on blood pressure.
• Dark chocolate, known for its vasodilatory properties, might enhance the drug's effects and should be consumed moderately.
• Garlic, a natural blood thinner, could potentially interact with the medication, so it's best to consult a healthcare professional for guidance.
• Always follow the dosage instructions provided by your healthcare provider, and inform them about any dietary habits or preferences that may influence the medication's effectiveness.

Glyceryl Trinitrate 6.4mg Capsules should be stored in a cool, dry, and dark place, preferably in a medicine cabinet or a designated storage area away from direct sunlight and heat. The capsules should be kept in their original container, tightly sealed, to maintain their potency and integrity. It is crucial not to store them in the bathroom or kitchen, as moisture and temperature fluctuations can impact their effectiveness. Always check the expiration date before use, and discard any expired capsules promptly. When disposing of unused or expired medication, do not throw them into the trash or flush them down the toilet. Instead, contact your local pharmacy or healthcare facility for guidance on proper disposal methods to ensure environmental safety. Keep the capsules out of children's reach to prevent accidental ingestion, and exercise caution when handling and storing this medication.

Following are the quick tips for Glyceryl Trinitrate 6.4mg Capsule:

• Consult a doctor for a personalized dosage plan.
• Store capsules in a cool, dry place, away from direct sunlight.
• Swallow the capsule whole with water; do not chew or crush it.
• Avoid alcohol consumption while taking this medication.
• Inform your doctor about all medications you are currently taking.
• Do not drive or operate machinery if you feel dizzy or lightheaded after taking the capsule.
• Contact your healthcare provider if symptoms worsen or new symptoms appear.
• Keep a record of your medication usage and refill your prescription in advance.