Nimixa (550mg) 10 Tablets

Rifaximin 550mg Tablet primarily acts by inhibiting bacterial RNA synthesis. It binds to the beta-subunit of bacterial RNA polymerase, which is responsible for RNA transcription. This binding interferes with the synthesis of essential RNA molecules required for bacterial growth and survival. Rifaximin specifically targets bacterial RNA polymerase, showing high affinity for this enzyme in various bacterial species, including both gram-positive and gram-negative bacteria. By blocking RNA synthesis, Rifaximin prevents the bacteria from producing the proteins and components necessary for their replication and metabolic processes, ultimately leading to bacterial growth inhibition and bactericidal effects. This mechanism of action contributes to the drug's effectiveness in treating various gastrointestinal infections caused by susceptible bacteria.

Antibiotic (Rifamycin Derivative)

Tablet

The following are the uses of Rifaximin 550mg Tablet:

• Used for treating traveler's diarrhea, reducing the risk of recurrent episodes.
• Used to manage symptoms of hepatic encephalopathy, a complication of liver disease.
• Used to alleviate abdominal pain and discomfort in Irritable Bowel Syndrome (IBS) patients.
• Used for reducing the overgrowth of bacteria in the small intestine, a condition known as Small Intestinal Bacterial Overgrowth (SIBO).
• Used for preventing and treating infections in the gastrointestinal tract.
• Used to support the gut microbiome by selectively targeting harmful bacteria.
• Used in combination with other medications for comprehensive gastrointestinal treatment.
• Used to improve overall digestive health and restore normal bowel function.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Traveler's diarrhea- 550 mg taken twice a day for 3 days.
• Hepatic encephalopathy- 550 mg taken twice a day.
• Irritable bowel syndrome (IBS) or small intestinal bacterial overgrowth (SIBO)- 550 mg taken three times a day.

In the case of an overdose of Rifaximin 550mg Tablets, individuals may experience gastrointestinal symptoms such as nausea, vomiting, diarrhea, and abdominal pain. The severity of these symptoms can vary depending on the amount ingested. It is important to seek medical advice promptly if an overdose is suspected. Treatment involves supportive care and managing any adverse effects, with a focus on alleviating gastrointestinal discomfort and ensuring the individual's well-being.

In the case of a missed dose of Rifaximin 550mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. If you frequently forget doses, consider setting an alarm or asking a family member to remind you to take your medication as prescribed. Consult your healthcare provider if you have any concerns or questions regarding missed doses.

To take Rifaximin 550mg Tablet, swallow the tablet whole with a glass of water, preferably on an empty stomach, or as directed by your healthcare professional, typically two to four times a day, following the prescribed dosage and treatment duration.

Following are the conditions when Rifaximin 550mg Tablet should not be taken:

• Should not be used in individuals with a known allergy to Rifaximin or other rifamycin antibiotics.
• Not suitable for the treatment of severe or life-threatening bacterial infections.
• Contraindicated in patients with a history of gastrointestinal obstruction or severe constipation.
• Avoid using in individuals with suspected or confirmed inflammatory bowel disease (IBD).
• Not recommended for patients with a history of liver disease or impaired liver function.
• Should not be used to treat bacterial infections caused by Rifaximin-resistant bacteria.
• Avoid using in patients with a history of hypersensitivity reactions to similar antibiotics.
• Contraindicated in patients with a history of severe renal impairment or kidney disease.

The side effects of Rifaximin 550mg Tablet may include:

• Abdominal pain or cramps
• Diarrhea
• Nausea and vomiting
• Constipation
• Flatulence (excessive gas)
• Dizziness
• Fatigue
• Allergic reactions (such as rash, itching, or swelling)

Following are the precautions and warnings:

• Rifaximin 550mg Tablet should not be used in patients with a known or suspected hypersensitivity or allergy to rifaximin or other rifamycin derivatives.
• This medication is intended for the treatment of specific intestinal infections and should not be used for systemic infections as it has limited systemic absorption.
• Patients with severe or persistent diarrhea should seek medical attention, as it may be a sign of a more serious condition.
• Caution is advised in patients with liver disease, as rifaximin is primarily metabolized in the liver.
• Rifaximin may cause a change in the color of urine to a light yellow or brown, which is usually temporary and harmless.
• Not recommended for use in children below 12 years of age unless prescribed by a healthcare professional.
• Pregnant and breastfeeding women should consult their doctor before taking this medication, as the risks and benefits should be carefully evaluated.
• Rifaximin may interact with other medications, so patients should inform their healthcare provider about all the medicines they are currently taking.

Following are the drug interactions for Rifaximin 550mg Tablet:

• Antibiotics like erythromycin or clarithromycin may decrease Rifaximin's absorption, reducing its effectiveness.
• Rifaximin can slow the metabolism of certain medications like midazolam, leading to increased side effects.
• The effect of warfarin and other anticoagulants may be altered, requiring close monitoring of blood clotting parameters.
• Rifaximin may increase the blood levels of cyclosporine, a medication used in organ transplants, necessitating dosage adjustments.
• Concomitant use with other antibiotics such as metronidazole or vancomycin might result in an additive effect on gut microbiota.
• Rifaximin may interact with antiepileptic drugs, potentially requiring adjustments in dosage.
• Caution is advised when combining Rifaximin with medications affecting kidney function, as it may lead to increased drug levels.

Following are the food interactions for Rifaximin 550mg Tablet:

• Avoid consuming alcohol during the treatment with Rifaximin as it may cause increased dizziness and drowsiness.
• There is no known interaction with specific foods, however, it is advisable to follow a healthy diet and maintain a balanced nutrition plan.
• Avoid high-fat meals as they may decrease the absorption of Rifaximin, potentially reducing its effectiveness.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Rifaximin, leading to increased side effects.
• Dairy products containing lactose may reduce the absorption of Rifaximin, so consider spacing out the intake of dairy and the medication.
• Avoid herbal teas or supplements containing St. John's Wort as they may decrease the effectiveness of Rifaximin.
• Always take Rifaximin on an empty stomach to ensure optimal absorption and effectiveness.
• Inform your healthcare provider about any dietary supplements or herbal products you are using to ensure safe and effective treatment.

Rifaximin 550mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. The medication bottle should be kept tightly sealed to maintain its integrity and effectiveness. It is crucial not to store the tablets in the bathroom or near heat-emitting appliances, as this can impact their quality. Always check the expiration date, and for disposal, do not flush or pour the medication down the drain. Consult your pharmacist for guidance on proper disposal methods to ensure environmental safety. Keep the medication away from children to prevent accidental consumption.

Following are the quick tips for Rifaximin 550mg Tablet:

• Take the tablet as directed by your doctor, usually 2 or 3 times a day.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or split it.
• Take the tablet with or without food, but ensure consistency in your routine.
• Avoid taking antacids or other medications within 1 hour of taking Rifaximin.
• Complete the full course of medication as prescribed, even if you feel better earlier.
• Store the tablets in their original packaging at room temperature, away from moisture.
• Do not share this medication with others, even if they have similar symptoms.

Rifaximin is an antibiotic that doctors prescribe to treat travelers' diarrhea and other intestinal infections. It is important to inform your doctor of your medical history, allergies, and any medications you currently take before starting Rifaximin. Although lab tests may not be necessary for a prescription, your doctor may perform routine lab tests, such as liver function tests, to ensure you can take the medication without harming your liver or other vital organs. It is essential to immediately inform your healthcare provider if you experience any signs or symptoms of an allergic reaction, such as rash, itching, difficulty breathing, or swelling of the mouth, face, or throat. To ensure the medication is effective in treating your condition, it is important to follow your doctor's dosing instructions and complete the full course of treatment. It is also essential to drink plenty of fluids while taking Rifaximin to prevent dehydration due to diarrhea. Before undergoing any lab tests, it is advisable to consult with your doctor or pharmacist to ensure that the tests are appropriate and can provide you with personalized guidance based on your medical history and condition.